DOI: 10.1055/s-00035024

Thrombosis and Haemostasis

Issue 07 · Volume 78 · 1997 DOI: 10.1055/s-008-40700

Thrombosis in the young

001
Rosendaal, Fritz R: Thrombosis in the Young: Epidemiology and Risk Factors. A Focus on Venous Thrombosis
007
Siscovick, D S; Schwartz, S M; Rosendaal, F R; Psaty, B M: Thrombosis in the Young: Effect of Atherosclerotic Risk Factors on the Risk of Myocardial Infarction Associated with Prothrombotic Factors
013
Grotta, James: Cerebrovascular Disease in Young Patients

Gene therapy for hemophilia: hopes and reality for the children of the new century

024
Eisensmith, Randy C; Woo, Savio L C: Viral Vector-Mediated Gene Therapy for Hemophilia B
031
Connelly, Sheila; Kaleko, Michael: Gene Therapy for Hemophilia A

Thrombopoietin

037
Cohen-Solal, Karine; Debili, Najet; Vainchenker, William; Wendling, Françoise: Thrombopoietin (Mpl-ligand) and the Regulation of Platelet Production
042
Begley, C Glenn: Clinical Studies with Megakaryocyte Growth and Development Factor (Mpl-ligand)

Hemostatic predictors of thrombosis: the contribution of epidemiology

047
Lowe, Gordon D O: Prediction of Postoperative Deep-Vein Thrombosis
053
Ridker, Paul M: Fibrinolytic and Inflammatory Markers for Arterial Occlusion: The Evolving Epidemiology of Thrombosis and Hemostasis

Platelet-leukocyte-endothelial cell cross-talk

060
Frenette, Paul S; Wagner, Denisa D: Insights into Selectin Function from Knockout Mice
065
Daviet, Laurent; McGregor, John L: Vascular Biology of CD36: Roles of this New Adhesion Molecule Family in Different Disease States

The protein C pathway

070
Esmon, Charles T; Ding, Wei; Yasuhiro, Katsuura; Gu, Jian-Ming; Ferrell, Gary; Regan, Lisa M; Stearns-Kurosawa, Deborah J; Kurosawa, Shimichiro; Mather, Timothy; Laszik, Zolton; Esmon, Naomi L: The Protein C Pathway: New Insights

Antiphospholipid antibodies

075
Galli, Monica; Finazzi, Guido; Barbui, Tiziano: Antiphospholipid Antibodies: Predictive Value of Laboratory Tests
079
Esmon, Naomi L; Smirnov, Mikhail D; Esmon, Charles T: Thrombogenic Mechanisms of Antiphospholipid Antibodies

Integrin signalling and vascular function

083
Hynes, Richard O; Bader, Bernhard L: Targeted Mutations in Integrins and their Ligands: Their Implications for Vascular Biology
088
Preissner, K T; May, A E; Wohn, K D; Germer, M; Kanse, S M: Molecular Crosstalk Between Adhesion Receptors and Proteolytic Cascades in Vascular Remodelling
096
Du, X; Ginsberg, Mark H: Integrin αIIbβ3 and Platelet Function

Understanding the initiation of blood coagulation

101
Schmaier, Alvin H: Contact Activation: A Revision
108
Bauer, Kenneth A: Activation of the Factor VII-Tissue Factor Pathway
112
Morrissey, James H; Neuenschwander, Pierre F; Huang, Qiuling; McCallum, Christine D; Su, Bixia; Johnson, Arthur E: Factor VIIa-Tissue Factor: Functional Importance of Protein-Membrane Interactions

Venous thromboembolism and cancer, a two-way clinical association

117
Agnelli, Giancarlo: Venous Thromboembolism and Gancer: a Two-Way Clinical Association
121
Prins, Martin H; Hettiarachchi, Rohan J K; Lensing, Anthonie W A; Hirsh, Jack: Newly Diagnosed Malignancy in Patients with VenousThromboembolism. Search or Wait and See?
126
Gallus, A S: Prevention of Post-operative Deep Leg Vein Thrombosis in Patients with Cancer
133
Levine, Mark N: Prevention of Thrombotic Disorders in Cancer Patients Undergoing Chemotherapy
137
Bona, Robert D; Hickey, Amy D; Wallace, Donna M: Efficacy and Safety of Oral Anticoagulation in Patients with Cancer
141
Prandoni, Paolo: Antithrombotic Strategies in Patients with Cancer

Molecular defects in rare bleeding disorders

145
Shovlin, Claire L: Molecular Defects in Rare Bleeding Disorders: Hereditary Haemorrhagic Telangiectasia
151
Cooper, David N; Millar, David S; Wacey, Adam; Banner, David W; Tuddenham, Edward G D: Inherited Factor VII Deficiency: Molecular Genetics and Pathophysiology
161
Cooper, David N; Millar, David S; Wacey, Adam; Pemberton, Susan; Tuddenham, Edward G D: Inherited Factor X Deficiency: Molecular Genetics and Pathophysiology

Antithrombotic therapy of acute stroke

173
Samama, M M; Desnoyers, P C; Conard, J; Bousser, M G: Acute Ischemic Stroke and Heparin Treatments
180
Sandercock, Peter: Antiplatelet Therapy with Aspirin in Acute Ischaemic Stroke
183
del Zoppo, Gregory J: Antithrombotic Therapy of Acute Stroke: Thrombolytic Agents

Pathogenesis of atherosclerosis: a l997 update

191
Gryglewski, Ryszard J; Korbut, Ryszard; Uracz, Wojciech; Malinski, Tadeusz: Crossroads of L-Arginine/Arachidonate Metabolism
195
Berliner, Judith; Leitinger, Norbert; Watson, Andrew; Huber, Joakim; Fogelman, Alan; Navab, Mohamad: Oxidized Lipids in Atherogenesis: Formation, Destruction and Action
200
Taubman, Mark B; Fallon, John T; Schecter, Alison D; Giesen, Peter; Mendlowitz, Milton; Fyfe, Billie S; Marmur, Jonathan D; Nemerson, Yale: Tissue Factor in the Pathogenesis of Atherosclerosis

Clinical trials with anti IIb/IIIa inhibitors in acute coronary syndromes

205
Tcheng, James E: Platelet Glycoprotein IIb/IIIa Integrin Blockade: Recent Clinical Trials in Interventional Cardiology
210
Werf, Frans Van de: Clinical Trials with Glycoprotein IIb/IIIa Receptor Antagonists in Acute Coronary Syndromes
214
Moliterno, David J; Topol, Eric J: Conjunctive Use of Platelet Glycoprotein IIb/IIIa Antagonists and Thrombolytic Therapy for Acute Myocardial Infarction

Platelets and signal transduction

220
Shattil, Sanford J; Gao, Jingbo; Kashiwagi, Hirokazu: Not Just Another Pretty Face: Regulation of Platelet Function at the Cytoplasmic Face of Integrin αIIbβ3
226
Levy-Toledano, Sylviane; Gallet, Carole; Nadal, Florence; Bryckaert, Marijke; Maclouf, Jacques; Rosa, Jean-Philippe: Phosphorylation and Dephosphorylation Mechanisms in Platelet Function: a Tightly Regulated Balance
234
Brass, Lawrence F; Molino, Marina: Protease-Activated G Protein-Coupled Receptors on Human Platelets and Endothelial Cells

PLENARY LECTURE – Shirley Johnson Lecture

242
Jamieson, Graham A: Pathophysiology of Platelet Thrombin Receptors

PLENARY LECTURE – Marion Barnhart

247
Fuster, Valentin; Fallon, John T; Badimon, J J; Nemerson, Yale: The Unstable Atherosclerotic Plaque: Clinical Significance and Therapeutic Intervention

New recombinant products in the treatment of hemophilias

256
Berntorp, Erik: Second Generation, B-Domain Deleted Recombinant Factor VIII
261
White, Gilbert C; Beebe, Aime; Nielsen, Brenda: Recombinant Factor IX

Platelet membrane glycoproteins

266
Clemetson, Kenneth J: Platelet GPIb-V-IX Complex
271
Gachet, Christian; Hechlel, Béatrice; Léon, Catherine; Vial, Catherine; Leray, Claude; Ohlmann, Philippe; Cazenave, Jean-Pierre: Activation of ADP Receptors and Platelet Function

Current status of activation markers in ischemic heart disease

276
Merlini, Piera Angelica; Ardissino, Diego: Current Status of Activation Markers in lschemic Heart Disease: Markers of Coagulation Activation
280
FitzGerald, Garret A; Tigges, Jessica; Barry, Patricia; Lawson, John A: Markers of Platelet Activation and Oxidant Stress in Atherothrombotic Disease

Tumors and fibrinolysis

285
Schmitt, M; Harbeck, N; Thomssen, C; Wilhelm, O; Magdolen, V; Reuning, U; Ulm, K; Höfler, H; Jänicke, F; Graeff, H: Clinical Impact of the Plasminogen Activation System in Tumor Invasion and Metastasis: Prognostic Relevance and Target for Therapy

Thrombophilia as a multigenic disorder

297
Seligsohn, Uri; Zivelin, Ariella: Thrombophilia as a Multigenic Disorder

Leukocyte-endothelial cell interactions

302
Mclntyre, Thomas M; Modur, Vijayanand; Prescott, Stephen M; Zimmerman, Guy A: Molecular Mechanisms of Early Inflammation
306
Furie, Bruce; Furie, Barbara C: Leukocyte Crosstalk at the Vascular Wall
310
Thiagarajan, Ravi R; Winn, Robert K; Harlan, John M: The Role of Leukocyte and Endothelial Adhesion Molecules in Ischemia – Reperfusion Injury

Oral contraceptives and thrombotic disease

315
Kluft, C; Lansink, M: Effect of Oral Contraceptives on Haemostasis Variables
327
Helmerhorst, F M; Bloemenkamp, K W M; Rosendaal, F R; Vandenbroucke, J P: Oral Contraceptives and Thrombotic Disease: Risk of Venous Thromboembolism
334
Thorogood, Margaret: Oral Contraceptives and Myocardial Infarction: New Evidence Leaves Unanswered Questions

Molecular basis of inherited thrombophilia: from genedefects to disease

339
Bayston, Trevor A; Lane, David A: Antithrombin: Molecular Basis of Deficiency
344
Reitsma, Pieter H: Protein C Deficiency: from Gene Defects to Disease
351
Borgel, Delphine; Gandrille, Sophie; Aiach, Martine: Protein S Deficiency

Clinical trials of direct thrombin inhibitors

357
Verstraete, Marc: Direct Thrombin Inhibitors: Appraisal of the Antithrombotic/ Hemorrhagic Balance
364
White, Harvey D: Clinical Trials of Direct Thrombin Inhibitors in Acute Ischaemic Syndromes
367
Hermann, Jean-Paul R; Kutryk, Michael J B; Serruys, Patrick W: Clinical Trials of Direct Thrombin Inhibitors During Invasive Procedures

Controversial issues in oral anticoagulant therapy

377
Koefoed, Birgitte Gade; Gulløv, Annette Lemche; Petersen, Palle: Prevention of Thromboembolic Events in Atrial Fibrillation
382
Turpie, Alexander G G: Antithrombotic Therapy Following Heart Valve Replacement

Thrombomodulin

386
Nesheim, Michael; Wang, Wei; Boffa, Michael; Nagashima, Mariko; Morser, John; Bajzar, Laszlo: Thrombin, Thrombomodulin and TAFI in the Molecular Link Between Coagulation and Fibrinolysis
392
Sadler, J Evan: Thrombomodulin Structure and Function
396
Öhlin, Ann-K; Norlund, Lena; Marlar, Richard A: Thrombomodulin Gene Variations and Thromboembolic Disease

Cytokines and thrombosis

401
Edgington, Thomas S; Dickinson, Craig D; Ruf, Wolfram: The Structural Basis of Function of the TF●VIIa Complex in the Cellular Initiation of Coagulation
406
Mantovani, Alberto; Sozzani, Silvano; Vecchi, Annunciata; Introna, Martino; Allavena, Paola: Cytokine Activation of Endothelial Cells: New Molecules for an Old Paradigm
415
ten Cate, Jan W; Poll, Tom van der; Levi, Marcel; Cate, Hugo ten; Deventer, Sander J H van: Cytokines: Triggers of Clinical Thrombotic Disease

PLENARY LECTURE – Sol Sherry Lecture

420
Vermylen, J; Hoylaerts, M F; Arnout, J: Antibody-Mediated Thrombosis

PLENARY LECTURE – Wright-Schulte Lecture

427
Rosing, Jan; Tans, Guido: Coagulation Factor V: An Old Star Shines Again

Platelet activation by collagen

434
Sixma, Jan J; van Zanten, G Henrita; Huizinga, Eric G; van der Plas, R Martijn; Verkley, Marilyn; Wu, Ya-Ping; Gros, Piet; de Groot, Philip G: Platelet Adhesion to Collagen: an Update
439
Moroi, Masaaki; Jung, S M: Platelet Receptors for Collagen

Pathophysiology of von Willebrand factor

445
Rand, Jacob H; Glanville, Robert W; Wu, Xiao-Xuan; Ross, Julia M; Zangari, Maurizio; Gordon, Ronald E; Schwartz, Elaine; Potter, Barry J: The Significance of Subendothelial von Willebrand Factor
451
Meyer, D; Fressinaud, E; Gaucher, C; Lavergne, J-M; Hilbert, L; Ribba, A-S; Jorieux, S; Mazurier, C; INSERM Network on Molecular Abnormalities in von Willebrand Disease: Gene Defects in 150 Unrelated French Cases with Type 2 von Willebrand Disease: from the Patient to the Gene

Genetic determinants of the risk of arterial thrombosis

457
Humphries, S E; Panahloo, A; Montgomery, H E; Green, F; Yudkin, J: Gene-Environment Interaction in the Determination of Levels of Haemostatic Variables Involved in Thrombosis and Fibrinolysis
462
Minno, Giovanni Di; Grandone, Elvira; Margaglione, Maurizio: Clinical Relevance of Polymorphic Markers of Arterial Thrombosis

Tissue factor pathway inhibitor: a protein in search for a disease

467
Sandset, Per Morten; Bendz, Bjørn: Tissue Factor Pathway Inhibitor: Clinical Deficiency States
471
Bajaj, Madhu S; Bajaj, S Paul: Tissue Factor Pathway Inhibitor: Potential Therapeutic Applications

New aspects of APC resistance

478
Bertina, Rogier M: Laboratory Diagnosis of Resistance to Activated Protein C (APC-resistance)
483
Dahlbäck, Björn: Resistance to Activated Protein C Caused by the Factor V R506Q Mutation ls a Common Risk Factor for Venous Thrombosis

Clinical use of low molecular weight heparins

489
Turkstra, Franktien; Koopman, Maira M W; Büller, Harry R: The Treatment of Deep Vein Thrombosis and Pulmonary Embolism

Metallo proteinases and vascular biology

497
Sato, Hiroshi; Okada, Yasunori; Seiki, Motoharu: Membrane-Type Matrix Metalloproteinases (MT-MMPs) in Cell Invasion

Crystal structure of coagulation proteins

501
Bode, Wolfram; Brandstetter, Hans; Mather, Timothy; Stubbs, Milton T: Comparative Analysis of Haemostatic Proteinases: Structural Aspects of Thrombin, Factor Xa, Factor IXa and Protein C
512
Banner, David W: The Factor Vlla / Tissue Factor Complex
516
Carrell, Robin; Skinner, Richard; Jin, Lei; Abrahams, Jan Pieter: Structural Mobility of Antithrombin and its Modulation by Heparin

Hyperhomocysteinemia and thrombosis

520
Boers, Godfried H J: Hyperhomocysteinemia as a Risk Factor for Arterial and Venous Disease. A Review of Evidence and Relevance
523
Rozen, Rima: Genetic Predisposition to Hyperhomocysteinemia: Deficiency of Methylenetetrahydrofolate Reductase (MTHFR)
527
Selhub, Jacob; D'Angelo, Armando: Hyperhomocysteinemia and Thrombosis: Acquired Conditions

Transgenic production of hemostasis proteins

532
Luboń, Henryk; Paleyanda, Rekha K: Vitamin K-Dependent Protein Production in Transgenic Animals
537
Butler, Stephen P; Cott, Kevin van; Subrumanian, Anuradha; Gwazduaskas, Francis C; Velander, William H: Current Progress in the Production of Recombinant Human Fibrinogen in the Milk of Transgenic Animals
543
Drohan, William N: The Past, Present and Future of Transgenic Bioreactors

The drug trials that have influenced our clinical practice in the treatment of thrombosis

548
Marder, Victor J: How Have Trials of Thrombolytics Influenced Clinical Management of Patients with Acute Myocardial Infarction
553
Kearon, Clive: Drug Trials That Have Influenced Our Practice in the Treatment of Venous Thromboembolism
558
Warlow, Charles; Wardlaw, Joanna: The Drug Trials That Have Influenced our Clinical Practice in Acute Ischaemic Stroke

New treatments of von Wiltebrand disease

562
Aledort, Louis M: von Willebrand Disease: From the Bedside to Therapy
566
Menache, Doris; Aronson, David L: New Treatments of von Willebrand Disease: Plasma Derived von Willebrand Factor Concentrates
571
Schwarz, Hans Peter; Turecek, Peter L; Pichler, Ludwig; Mitterer, Artur; Mundt, Wolfgang; Dorner, Friedrich; Roussi, Jacqueline; Drouet, Ludovic: Recombinant von Willebrand Factor

Thrombin and its modulation

577
Leung, Lawrence L K; Gibbs, Craig S: Modulation of Thrombin’s Procoagulant and Anticoagulant Properties
581
Brass, Lawrence F; Manning, David R; Cichowski, Karen; Abrams, Charles S: Signaling through G Proteins in Platelets: to the Integrins and Beyond
590
Béguin, S; Kumar, R: Thrombin, Fibrin and Platelets: a Resonance Loop in which von Willebrand Factor is a Necessary Link

Structure and mechanism of action of vitamin K-dependent gamrnt-ctrboxylase

595
Furie, Barbara C; Furie, Bruce: Structure and Mechanism of Action of the Vitamin K-Dependent γ-Glutamyl Carboxylase: Recent Advances from Mutagenesis Studies
599
Stafford, Darrel W; Wu, S M; Stanley, Thomas B; Mutucumarana, Vasantha P: Characterization of the ϒ-Glutamyl Carboxylase

Plenary Lecture

605
Clowes, Alexander W: Vascular Gene Therapy in the 21st Century
611
Ruggeri, Zaverio M: Mechanisms Initiating Platelet Thrombus Formation

Bleeding and thrombosis in myeloproliferative disorders

617
Landolfi, Raffaele; Marchioli, Roberto; Patrono, Carlo: Mechanisms of Bleeding and Thrombosis in Myeloproliferative Disorders
622
Murphy, Scott: Therapeutic Dilemmas: Balancing the Risks of Bleeding, Thrombosis, and Leukemic Transformation in Myeloproliferative Disorders (MPD)

New aspects of arachidonic acid metabolism

627
Smith, William L; DeWitt, David L; Arakawa, Toshiya; Spencer, Andrew G; Thuresson, Elizabeth D; Song, Inseok: Independent Prostanoid Biosynthetic Systems Associated with Prostaglandin Endoperoxide Synthases-1 and -2

Epidemiology of inherited thrombophilia

631
Meer, Felix J M van der; Koster, T; Vandenbroucke, J P; Briët, E; Rosendaal, Frits R: The Leiden Thrombophilia Study (LETS)
636
Rodeghiero, Francesco; Tosetto, Alberto: The Epidemiology of lnherited Thrombophilia: the VITA Project

Factor VIII and factor IX inhibitors

641
Gilles, Jean Guy G; Jacquemin, Marc G; Saint-Remy, Jean-Marie R: Factor VIII Inhibitors
647
Lollar, Pete: Analysis of Factor VIII Inhibitors Using Hybrid Human/Porcine Factor VIII

Plasminogen activator inhibitor I (PAI-1)

652
David, J Loskutoff; Fahumiya, Samad: The Fat Mouse: A Powerful Genetic Model to Study Elevated Plasminogen Activator Inhibitor 1 in Obesity/NIDDM
656
Juhan-Vague, I; Alessi, M C: PAI-1, Obesity, Insulin Resistance and Risk of Cardiovascular Events

Special Symposium

661
Martinowitz, Uri; Spotnitz, William D: Fibrin Tissue Adhesives

Animal models of thrombotic and hemorrhagic disorders

667
Badimon, Lina: Models to Study Thrombotic Disorders

Angiogenesis

672
Iruela-Arispe, Luisa M; Dvorak, Harold F: Angiogenesis: a Dynamic Balance of Stimulators and Inhibitors
678
Breier, Georg; Damert, Annette; Plate, Karl H; Risau, Werner: Angiogenesis in Embryos and Ischemic Diseases

Prevention and treatment of deep vein thrombosis

684
David, Bergqvist: New Approaches to Prevention of Deep Vein Thrombosis
689
Hirsh, Jack; Crowther, Mark: Low Molecular Weight Heparin for the Out-of-Hospital Treatment of Venous Thrombosis: Rationale and Clinical Results
693
Schulman, Sam: Optimal Duration of Oral Anticoagulant Therapy in Venous Thromboembolism

Lessons from gene knock-out technology

699
Huang, Zhong-Fu; Broze, George: Consequences of Tissue Factor Pathway Inhibitor Gene-Disruption in Mice
705
Rosenberg, Robert D: Thrombomodulin Gene Disruption and Mutation in Mice

Disorders of hemostasis in childhood

710
Manco-Johnson, Marilyn J: Disorders of Hemostasis in Childhood: Risk Factors for Venous Thromboembolism
715
Andrew, Maureen; David, Michelle; deVeber, Gabrielle; Brooker, Lu Ann: Arterial Thromboembolic Complications in Paediatric Patients
726
Lusher, Jeanne M: Prophylaxis in Children with Hemophilia: Is it the Optimal Treatment?

Newer antithrombotic agents

730
Coller, Barry S: GPIIb/IIIa Antagonists: Pathophysiologic and Therapeutic Insights from Studies of c7E3 Fab
736
Harker, Laurence A; Hanson, Stephen R; Kelly, Andrew B: Antithrombotic Strategies Targeting Thrombin Activities, Thrombin Receptors and Thrombin Generation
742
Collen, Désiré: Thrombolytic Therapy

Tissue factor

747
Mackman, Nigel: Regulation of the Tissue Factor Gene
755
Østerud, Bjarne: Tissue Factor: a Complex Biological Role
759
Semeraro, Nicola; Colucci, Mario: Tissue Factor in Health and Disease

Hormone replacement therapy in postmenopausal women and cardiovascular risk

765
Meade, T W: Hormone Replacement Therapy and Haemostatic Function
770
Chae, Claudia U; Ridker, Paul M; Manson, JoAnn E: Postmenopausal Hormone Replacement Therapy and Cardiovascular Disease