Thromb Haemost 1997; 78(01): 512-515
DOI: 10.1055/s-0038-1657578
Crystal structure of coagulation proteins
Schattauer GmbH Stuttgart

The Factor Vlla / Tissue Factor Complex

David W Banner
Pharma Division, F. Hoffmann-La Roche, Basle, Switzerland
› Author Affiliations
Further Information

Publication History

Publication Date:
12 July 2018 (online)

 
  • References

  • 1 Nemerson Y. Tissue Factor and hemostasis. Blood 1988; 71: 1-8
  • 2 Rapaport SI, Rao LVM. The tissue factor pathway: how it has become a ‘Prima Ballerina’. Thromb Haemost 1995; 74: 7-17
  • 3 Kirchhofer D, Guha A, Nemerson Y, Konigsberg WH, Vilbois F, Chène C, Banner DW, D’Arcy A. Activation of blood coagulation factor VIIa with cleaved tissue factor extracellular domain and crystallization of the active complex. Proteins 1995; 22: 419-425
  • 4 Banner DW, D’Arcy A, Chène C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 1996; 380: 41-46
  • 5 Dickinson CD, Kelly CR, Ruf W. Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa. Proc Natl Acad Sci USA 1996; 93: 14379-14384
  • 6 Bazan JF. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 1990; 87: 6934-6938
  • 7 Harlos K, Martin DMA, O’Brien DP, Jones EY, Stuart D, Polikarpov DI, Miller A, Tuddenham EGD, Boys CWG. Crystal structure of the extracellular region of human tissue factor. Nature 1994; 370: 662-666
  • 8 Muller YA, Ultsch MH, Kelley RF, de VosAM. Structure of the extracellular domain of human tissue factor: location of the factor VIIa binding site. Biochemistry 1994; 33: 10864-10870
  • 9 Walter MR, Windsor WT, Nagabhushan TL, Lundell DJ, Lunn CA, Zauodny PJ, Narula SK. Crystal structure of a complex between interferon-g and its soluble high-affinity receptor. Nature 1995; 376: 230-235
  • 10 Bromberg ME, Konigsberg WH, Madison JF, Pawashe A, Garen A. Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation. Proc Natl Acad Sci USA 1995; 92: 8205-8209
  • 11 Zhang Y, Deng Y, Luther T, Muller M, Ziegler R, Waldherr R, Stern DM, Nawroth PR. Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice. J Clin Invest 1994; 94: 1320-1327
  • 12 Røttingen J-A, Enden T, Camerer E, Iversen J-G, Prydz H. Binding of human factor VIIa to tissue factor induces cytosolic Ca2+signals in J82 cells, transfected COS-1 cells, Madin-Darby canine kidney cells and in human endothelial cells induced to synthesize tissue factor. J Biol Chem 1995; 270: 4650-4660
  • 13 Camerer E, Røttingen J-A, Iversen J-G, Prydz H. Coagulation factors VII and X induce Ca2+oscillations in Madin-Darby canine kidney cells only when proteolytically active. J Biol Chem 1996; 271: 29034-29042
  • 14 Wilcox JN, Smith KM, Schwartz SM, Gordon D. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc Natl Acad Sci USA 1989; 86: 2839-2843
  • 15 Camerer E, Kolst A-B, Prydz H. Cell biology of tissue factor, the principal initiator of blood coagulation. Thromb Res 1996; 81: 1-41
  • 16 Marmur JD, Rossikhina M, Guha A, Fyfe B, Friedrich V, Mendlowitz M, Nemerson Y, Taubman MB. Tissue factor is rapidly induced in arterial smooth muscle after balloon injury. J Clin Invest 1993; 91: 2253-2259
  • 17 Speidel CM, Eisenberg PR, Ruf W, Edgington TS, Abendschein DR. Tissue factor mediates prolonged procoagulant activity on the luminal surface of balloon-injured aortas in rabbits. Circulation 1995; 92: 3323-3330
  • 18 Jang Y, Guzman LA, Lincoff AM, Gottsauner-Wolf M, Forudi F, Hart CE, Courtman DW, Ezban M, Ellis SG, Topol EJ. Influence of blockade at specific levels of the coagulation cascade on restenosis in a rabbit atherosclerotic femoral artery injury model. Circulation 1995; 92: 3041-3050
  • 19 Annex BH, Denning SM, Channon KM. Differential expression of tissue factor protein in directional atherectomy specimens from patients with stable and unstable coronary syndromes. Circulation 1995; 91: 619-22
  • 20 Marmur JD, Thiruvikraman SV, Fyfe BS, Guha A, Sharma SK, Ambrose JA, Fallon JT, Nemerson Y, Taubman MB. Identification of active tissue factor in human coronary atheroma. Circulation 1996; 94: 1226-1232
  • 21 Ashton AW, Kemball-Cook G, Johnson DJD, Martin DMA, O’Brien DP, Tuddenham EGD, Perkins SJ. Factor VIIa and the extracellular domains of human tissue factor form a compact complex: a study by X-ray and neutron solution scattering. FEBS lett 1995; 374: 141-146
  • 22 McCallum CD, Hapak RC, Neuenschwander PF, Morrissey JH, Johnson AE. The location of the active site of blood coagulation factor VIIa above the membrane surface and its reorientation upon association with tissue factor - A fluorescence energy transfer study. J Biol Chem 1996; 271: 28168-28175
  • 23 Mutucumarana VP, Duffy EJ, Lollar P, Johnson AE. The active site of factor IXa is located far above the membrane surface and its conformation is altered upon association with factor VIIIa - A fluorescence study. J Biol Chem 1992; 267: 17012-17021
  • 24 Husten EJ, Esmon CT, Johnson AE. The active site of blood coagulation factor Xa - Its distance from the phospholipid surface and its conformational sensitivity to components of the prothrombinase complex. J Biol Chem 1987; 262: 12953-12961
  • 25 Lu R, Esmon NL, Esmon CT, Johnson AE. The active site of the thrombin-thombomodulin complex. A fluorescence energy transfer measurement of its distance above the membrane surface. J Biol Chem 1989; 264: 12956-12962
  • 26 Ruf W, Kelly CR, Schullek JR, Martin DM, Polikaipov I, Boys CW, Tuddenham EG, Edgington TS. Energetic contributions and topographical organization of ligand binding residues of tissue factor. Biochemistry 1995; 34: 6310-6315
  • 27 Ruf W, Kalnik MW, Lund-Hansen T, Edgington TS. Characterization of factor VII association with tissue factor in solution - High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions. J Biol Chem 1991; 266: 15719-15725
  • 28 Kazama Y, Patuszyn A, Wildgoose P, Hamamoto T, Kisiel W. Isolation and characterization of proteolytic fragments of human factor VIIa which inhibit tissue factor-enhanced amidolytic activity of factor VIIa. J Biol Chem 1993; 268: 16231-16240
  • 29 Sakai T, Lund-Hansen T, Thim L, Kisiel W. The g-carboxyglutamic acid domain of human factor VIIa is essential for its interaction with cell surface tissue factor. J Biol Chem 1990; 265: 1890-1894
  • 30 Petersen LC, Schiødt J, Christensen U. Involvement of the hydrophobic stack residues 39-44 of factor VIIa in tissue factor interactions. FEBS lett 1994; 347: 73-79
  • 31 Rehemtulla A, Ruf W, Edgington TS. The integrity of the cysteine 186-cysteine 209 bond of the second disulfide loop of tissue factor is required for binding of factor VII. J Biol Chem 1991; 266: 10294-10299
  • 32 Ruf W, Schullek JR, Stone MJ, Edgington TS. Mutational mapping of functional residues in tissue factor: identification of factor VII recognition determinants in both structural modules of the predicted cytokine receptor homology domain. Biochemistry 1994; 33: 1565-1572
  • 33 Gibbs CS, McCurdy SN, Leung LLK, Paborsky LR. Identification of the factor VIIa binding site on tissue factor by homologous loop swap and alanine scanning mutagenesis. Biochemistry 1994; 33: 14003-14010
  • 34 Kelley RF, Costas KE, O’Connell MP, Lazarus RA. Analysis of the factor VIIa binding site on human tissue factor: effects of tissue factor mutations on the kinetics and thermodynamics of binding. Biochemistry 1995; 34: 10383-10392
  • 35 Clarke BJ, Ofosu FA, Sridhara S, Bona RD, Rickies FR, Blajchman MA. The first epidermal growth factor domain of human coagulation factor VII is essential for binding with tissue factor. FEBS lett 1992; 298: 206-210
  • 36 Toomey JR, Smith KJ, Stafford DW. Localization of the human tissue factor recognition determinant of human factor VIIa. J Biol Chem 1991; 266: 19198-19202
  • 37 Chang JY, Stafford DW, Straight DL. The roles of factor VII’s structural domains in tissue factor binding. Biochemistry 1995; 34: 12227-12232
  • 38 Kelly CR, Schullek JR, Ruf W, Edgington TS. Tissue factor residue Asp44regulates catalytic function of the bound proteinase factor VIIa. Biochem J 1996; 315: 145-151
  • 39 Waxman E, Laws WR, Laue TM, Nemerson Y, Ross JBA. Human factor VIIa and its complex with soluble tissue factor: evaluation of asymmetry and conformational dynamics by ultracentrifugation and fluorescence anisotropy decay methods. Biochemistry 1993; 32: 3005-3012
  • 40 Higashi S, Nishimura H, Aita K, Iwanaga S. Identification of regions of bovine factor VII essential for binding to tissue factor. J Biol Chem 1994; 269 (29) 18891-18898
  • 41 Higashi S, Matsumoto N, Iwanaga S. Molecular mechanism of tissue factor-mediated acceleration of factor VIIa activity. J Biol Chem 1996; 271 (43) 26569-26574
  • 42 Neuenschwander PF, Morrissey JH. Alteration of the substrate and inhibitor specificities of blood coagulation factor VIIa: Importance of amino acid residue K192 . Biochemistry 1995; 34: 8701-8707
  • 43 Ruf W. Factor VIIa residue Arg290is required for efficient activation of the macromolecular substrate factor X. Biochemistry 1994; 33: 11631-11636
  • 44 Vijayalakshmi J, Padmanabhan KP, Mann KG, Tulinsky A. The isomorphous structures of prethromin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin. Protein Sci 1994; 3: 2254-2271
  • 45 Kraulis PJ. “MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures”. J. appl. Crystallogr 1991; 24: 946-950