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Thromb Haemost 1997; 78(01): 242-246
DOI: 10.1055/s-0038-1657533
PLENARY LECTURE – Shirley Johnson Lecture
Schattauer GmbH Stuttgart

Pathophysiology of Platelet Thrombin Receptors

Graham A Jamieson
American Red Cross, 15601 Crabbs Branch Way, Rockville, MD, USA
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Publication History

Publication Date:
12 July 2018 (online)

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  • References

  • 1 Jamieson GA. The activation of platelets by thrombin: A model for activation by high and moderate affinity receptor pathways. In: Jamieson GA. ed Platelet Membrane Receptors: Molecular Biology, Immunology, Biochemistry, and Pathology. New York: Alan R. Liss, Inc.; 1988: 137-158
    Google Scholar
  • 2 Greco NJ, Jamieson GA. High and moderate affinity pathways for α-thrombin-induced platelet activation. Proc Soc Exp Biol Med 1991; 198: 792-799
    CrossrefPubMedGoogle Scholar
  • 3 Harmon JT, Jamieson GA. Thrombin binds to a high-affinity ∼900,000 dal ton site on human platelets. Biochemistry 1985; 24: 58-64
    CrossrefPubMedGoogle Scholar
  • 4 DeMarco L, Mazzucato M, Masotti A, Fenton JW, Ruggeri ZM. Function of glycoprotein lb alpha in platelet activation induced by alph α-thrombin. J Biol Chem 1991; 266: 23776-23783
    PubMedGoogle Scholar
  • 5 Gralnick HR, Williams S, McKeown LP, Hansmann K, Fenton III JW, Krutzsch H. High-affinity α-thrombin binding to platelet glycoprotein Ibα: Identification of two binding domains. Proc Natl Acad Sci USA 1994; 91: 6334-6338
    CrossrefPubMedGoogle Scholar
  • 6 Greco NJ, Tenner Jr TE, Tandon NN, Jamieson GA. PPACK-thrombin inhibits thrombin-induced platelet aggregation and cytoplasmic acidification but does not inhibit platelet shape change. Blood 1990; 75: 1983-1990
    PubMedGoogle Scholar
  • 7 Greco NJ, Tandon NN, Jamieson GA. Thrombin binding to platelets defines functional receptors: Inhibition of thrombin- induced platelet activation by catalytically-inactivated thrombin. Platelets 1995; 06: 270-274
    CrossrefPubMedGoogle Scholar
  • 8 Mazurov AV, Vinogradov DV, Vlasik TN, Repin VS, Booth WJ, Berndt MC. Characterization of an antiglycoprotein lb monoclonal antibody that specifically inhibits platelet-thrombin interaction. Thromb Res 1991; 62: 673-684
    CrossrefPubMedGoogle Scholar
  • 9 Greco NJ, Tandon NN, Jones GD. et al Contributions of glycoprotein lb and the seven transmembrane domain receptor to increases in platelet cytoplasmic [Ca2+]iinduced by α-thrombin. Biochemistry 1996; 35: 906-914
    CrossrefPubMedGoogle Scholar
  • 10 Peng M, Emig FA, Mao A. et al Interaction of echicetin with a high affinity thrombin binding site on platelet glycoprotein GPIb. Thromb Haemost 1995; 74: 954-957
    Article in Thieme ConnectPubMedGoogle Scholar
  • 11 McNicol A, Sutherland M, Zou r, Drouin J. Defective thrombin- induced calcium changes and aggregation of Bernard-Soulier platelets are not associated with deficient moderate-affinity receptors. Arterioscler Thromb & Vascular Biol 1996; 16: 628-632
    PubMedGoogle Scholar
  • 12 Harmon JT, Jamieson GA. Activation of platelets by alpha-thrombin is a receptor-mediated event. J Biol Chem 1986; 261: 15928-15933
    PubMedGoogle Scholar
  • 13 Brower MS, Levin RI, Garry K. Human neutrophil elastase modulates platelet function by limited proteolysis of membrane glycoproteins. J Clin Invest 1985; 75: 657-666
    CrossrefPubMedGoogle Scholar
  • 14 Greco NJ, Jones GD, Tandon NN, Kornhauser R, Jackson B, Jamieson GA. Differentiation of the two forms of GPIb functioning as receptors for α-thrombin and von Willebrand factor: Ca2+responses of protease-treated human platelets activated with α-thrombin and the tethered ligand peptide. Biochemistry 1996; 35: 915-921
    CrossrefPubMedGoogle Scholar
  • 15 Lopez JA. The platelet glycoprotein Ib-IX complex. Blood Coagul Fibrinolysis 1994; 05: 97-119
    CrossrefPubMedGoogle Scholar
  • 16 Parry MAA, Stone SR, Hofsteenge J, Jackman MP. Evidence for common structural changes in thrombin induced by active-site or exosite binding. Biochem J 1993; 290: 665-670
    CrossrefPubMedGoogle Scholar
  • 17 Vijayalakshmi J, Padmanabhan KP, Mann KG, Tulinsky A. The isomorphous structures of prethrombin2, hirugen-, and PPACK- thrombin: Changes accompanying activation and exosite binding to thrombin. Protein Sci 1994; 03: 2254-2271
    CrossrefPubMedGoogle Scholar
  • 18 Wu Q, Sheehan JP, Tsiang M, Lentz SR, Birktoft JJ, Sadler JE. Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin. Proc Natl Acad Sci USA 1991; 88: 6775-6779
    CrossrefPubMedGoogle Scholar
  • 19 Okumura T, Jamieson GA. A single receptor for platelet aggregation induced by thrombin or ristocetin. Thromb Res 1976; 08: 701-706
    CrossrefPubMedGoogle Scholar
  • 20 DeMarco L, Mazzucato M, Masotti A, Ruggeri ZM. Localization and characterization of an a-thrombin-binding site on platelet glycoprotein Iba. J Biol Chem 1994; 269: 6478-6484
    CrossrefPubMedGoogle Scholar
  • 21 Ward CM, Andrews RK, Smith AI, Bemdt MC. Mocarhagin, a novel cobra venom metalloproteinase, cleaves the platelet von Willebrand factor receptor glycoprotein Ibα. Identification of the sulfated tyrosine/anionic sequence Tyr-276-Glu-282 of glycoprotein Iba as a binding site for von Willebrand factor and a-thrombin. Biochemistry 1996; 35: 4929-4938
    CrossrefPubMedGoogle Scholar
  • 22 Marchese P, Murata M, Mazzucato M. et al Identification of three tyrosine residues of glycoprotein Ibα with distinct roles in von Willebrand factor and a-thrombin binding. J Biol Chem 1995; 16: 9571-9578
    PubMedGoogle Scholar
  • 23 Dong J-F, Li CQ, Lopez JA. Tyrosine sulfation of the glycoprotein Ib-IX complex: Identification of sulfated residues and effect on ligand binding. Biochemistry 1994; 33: 13946-13953
    CrossrefPubMedGoogle Scholar
  • 24 Wyler B, Bienz D, Clemetson KJ, Luscher EF. Glycoprotein Ibα is the only phosphorylated major membrane glycoprotein in human platelets. Biochem J 1986; 234: 373-379
    CrossrefPubMedGoogle Scholar
  • 25 Vu T-KH, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64: 1057-1068
    CrossrefPubMedGoogle Scholar
  • 26 Rasmussen UB, Vouret-Craviari V, Jallat S. et al: cDNA cloning and expression of a hamster α-thrombin receptor coupled to Ca2+mobilization. FEBS Lett 1991; 288: 123-128
    CrossrefPubMedGoogle Scholar
  • 27 Brass LF, Vassallo Jr RR, Belmonte E, Ahuja M, Cichowski K, Hoxie JA. Structure and function of the human platelet thrombin receptor. J Biol Chem 1992; 267: 13795-13798
    PubMedGoogle Scholar
  • 28 Lau L-F, Pumiglia K, Cote YP, Feinstein MB. Thrombin-receptor agonist peptides, in contrast to thrombin itself, are not full agonists for activation and signal transduction in human platelets in the absence of platelet-derived secondary mediators. Biochem J 1994; 303: 391-400
    CrossrefPubMedGoogle Scholar
  • 29 Kramer RM, Roberts EF, Hyslop PA, Utterback BG, Hui KY, Jakubowski JA. Differential activation of cytosolic phospholipase A2(cPLA2) by thrombin and thrombin receptor agonist peptide in human platelets. J Biol Chem 1995; 270: 14816-14823
    CrossrefPubMedGoogle Scholar
  • 30 Goodwin CA, Wheeler-Jones CPD, Kakkar VV, Deadman JJ, Authi KS, Scully MF. Thrombin receptor activating peptide does not stimulate platelet procoagulant activity. Biochem Biophys Res Commun 1994; 202: 321-327
    CrossrefPubMedGoogle Scholar
  • 31 Sugama Y, Tiruppathi CM, Janakidevi K, Andersen TT, Fenton II JW, Main AB. Thrombin-induced expression of endothelial P-Selectin and intercellular adhesion molecule-1: A mechanism for stabilizing neutrophil adhesion. J Cell Biol 1992; 119: 935-944
    CrossrefPubMedGoogle Scholar
  • 32 Lum H, Andersen TT, Siflinger-Birnboim A. et al: Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization. J Cell Biol 1993; 120: 1491-1499
    CrossrefPubMedGoogle Scholar
  • 33 Lenormand P, Sardet C, Pages G, L’Alleman G, Brunet A, Pouyssegur J. Growth factors induce nuclear translocation of MAP kinases (p42mapkand p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts. J Cell Biol 1993; 122: 1079-1088
    CrossrefPubMedGoogle Scholar
  • 34 Vouret-Craviari V, Van Obberghen-SchillingE, Scimeca JC, Van ObberghenE, Pouyssegur J. Differential activation of p44 mapk (ERK1) by α-thrombin and thrombin-receptor peptide agonist. Biochem J 1993; 289: 209-214
    CrossrefPubMedGoogle Scholar
  • 35 Jenkins AL, Bootman MD, Derridge MJ, Stone SR. Differences in intracellular calcium signaling after activation of the thrombin receptor by thrombin and agonist peptide in osteoblast-like cells. J Biol Chem 1994; 269: 17104-17110
    PubMedGoogle Scholar
  • 36 Connolly AJ, Ishihara H, Kahn ML, Farese Jr RV, Coughlin SR. Role of the thrombin receptor in development and evidence for a second receptor. Nature 1996; 381: 516-519
    CrossrefPubMedGoogle Scholar
  • 37 Darrow AL, Fung-Leung W-P, Ye RD. et al: Biological consequences of thrombin receptor deficiency in mice. Thromb Haemost 1996; 76: 860-866
    Article in Thieme ConnectPubMedGoogle Scholar
  • 38 Seiler SM, Michel IM, Fenton JW. Involvement of the “tethered-ligand” receptor in thrombin inhibition of platelet adenylate cyclase. Biochem Biophys Res Commun 1992; 182: 1296-1302
    CrossrefPubMedGoogle Scholar
  • 39 Baffy G, Yang L, Raj S, Manning DR, Williamson JR. G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts. J Biol Chem 1994; 269: 8483-8487
    PubMedGoogle Scholar
  • 40 Du X, Harris SJ, Tetaz TJ, Ginsberg MH, Berndt MC. Association of a phospholipase A2(14-3-3 protein) with the platelet glycoprotein Ib-IX complex. J Biol Chem 1994; 269: 18287-18290
    PubMedGoogle Scholar
  • 41 Ishii K, Chen J, Koch WJ, Freedman NJ, Lefkowitz RJ, Coughlin SR. Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. J Biol Chem 1994; 269: 1125-1130
    PubMedGoogle Scholar
  • 42 Hung DT, Vu T-KH, Nelken NA, Coughlin SR. Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation. J Clin Invest 1992; 89: 1350-1353
    CrossrefPubMedGoogle Scholar
  • 43 Ishii K, Hein L, Kobilka B, Coughlin SR. Kinetics of thrombin receptor cleavage on intact cells. J Biol Chem 1993; 268: 9780-9786
    PubMedGoogle Scholar
  • 44 Shuman MA, Levine SP. Thrombin generation and secretion of platelet factor 4 during blood clotting. J Clin Invest 1978; 61: 1102-1106
    CrossrefPubMedGoogle Scholar
  • 45 Wewer UM, Liotta LA, Jaye M. et al: Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to binding laminin. Proc Natl Acad Sci USA 1986; 83: 7137-7141
    CrossrefPubMedGoogle Scholar
  • 46 Smalheiser NR, Schwartz NB. Cranin: A laminin-binding protein of cell membranes. Proc Natl Acad Sci USA 1987; 84: 6457-6461
    CrossrefPubMedGoogle Scholar
  • 47 Terranova VP, Rao CN, Kalebic T, Margulies IM, Liotta LA. Laminin receptor on human breast carcinoma cells. Proc Natl Acad Sci USA 1983; 80: 444-448
    CrossrefPubMedGoogle Scholar
  • 48 Liu L, Freedman J, Hornstein A, Fenton II JW, Song Y, Ofosu FA. Binding of thrombin to the G-protein-linked receptor, and not to glycoprotein lb, precedes thrombin-mediated platelet activation. J Biol Chem 1997; 272: 1997-2004
    CrossrefPubMedGoogle Scholar
  • 49 From an address at the inauguration of the Faculty of Science of the University of Lille. 07..1854. in R. ValleryRadotLa Vie de Pasteur(1900) Ch. 4