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Thromb Haemost 1997; 78(01): 627-630
DOI: 10.1055/s-0038-1657601
New aspects of arachidonic acid metabolism
Schattauer GmbH Stuttgart

Independent Prostanoid Biosynthetic Systems Associated with Prostaglandin Endoperoxide Synthases-1 and -2

William L Smith
Department of Biochemistry, Michigan State University, East Lansing, Ml 48824, USA
,
David L DeWitt
Department of Biochemistry, Michigan State University, East Lansing, Ml 48824, USA
,
Toshiya Arakawa
Department of Biochemistry, Michigan State University, East Lansing, Ml 48824, USA
,
Andrew G Spencer
Department of Biochemistry, Michigan State University, East Lansing, Ml 48824, USA
,
Elizabeth D Thuresson
Department of Biochemistry, Michigan State University, East Lansing, Ml 48824, USA
,
Inseok Song
Department of Biochemistry, Michigan State University, East Lansing, Ml 48824, USA
› Author Affiliations
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Publication History

Publication Date:
30 July 2018 (online)

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  • References

  • 1 Murakami M, Kudo I, Inoue K. Molecular nature of phospholipases A2 involved in prostaglandin I2 synthesis in human umbilical vein endothelial cells. Possible participation of cytosolic and extracellular type II phospholipases A2. J Biol Chem 1993; 268: 839-844
    PubMedGoogle Scholar
  • 2 Murakami M, Matsumoto R, Austen KF, Arm JP. Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells. J Biol Chem 1994; 269: 22269-22275
    PubMedGoogle Scholar
  • 3 Reddy ST, Herschman HR. Ligand-induced prostaglandin synthesis requires expression of the TIS10/PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages. J Biol Chem 1994; 269: 15473-15480
    PubMedGoogle Scholar
  • 4 Morita I, Schindler M, Regier MK, Otto JC, Hori T, DeWitt DL. et al. Different intracellular locations for prostaglandin endoperoxide H synthases-1 and -2. J Biol Chem 1995; 270: 10902-10908
    CrossrefPubMedGoogle Scholar
  • 5 Langenbach R, Morhan SG, Tiano HF, Loftin CD, Ghanayem BI, Chulada PC. et al. Prostglandin synthase I gene disruption in mice reduces arachidonic acid induced inflammation and indomethacin induced gastric ulceration. Cell 1995; 83: 483-493
    CrossrefPubMedGoogle Scholar
  • 6 Morham SG, Langenbach R, Loftin CD, Tiano HF, Vouloumanos N, Jennette JC. et al. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 1995; 83: 473-482
    CrossrefPubMedGoogle Scholar
  • 7 Patrignani P, Panara MR, Greco A, Fusco O, Natoli C, Iacobelli S. et al. Biochemical and pharmacological characterization of the cyclooxygenase activity of hum anblood prostaglandin endoperoxide synthases. J Pharmacol ExpTher 1994; 271: 1705-1712
    PubMedGoogle Scholar
  • 8 Smith W, Bell TG. Immunohistochemical localization of the prostaglandin-forming cyclooxygenase in renal cortex. Amer J Physiol 1978; 235: F451-F457
    PubMedGoogle Scholar
  • 9 Marcus AJ, Weksler BB, Jaffe EA, Broekman JM. Synthesis of prostacyclin from platelet-derived endoperoxides by cultured human endothelial cells. J Clin Invest 1980; 66: 979-986
    CrossrefPubMedGoogle Scholar
  • 10 Grenier FC, Rollins TE, Smith WL. Kinin-induced prostaglandin synthesis by renal papillary collecting tubule cells. Amer J Physiol 1981; 241: F094-F101
    PubMedGoogle Scholar
  • 11 Bonventre JA. Phospholipase A2 and signal transduction. J Am Soc Nephrol 1992; 03: 128-143
    PubMedGoogle Scholar
  • 12 Dennis EA. Diversity of group types, regulation and function of phospholipase A2. J Biol Chem 1994; 269: 1057-1060
    PubMedGoogle Scholar
  • 13 Riendeau D, Guay J, Weech PK, Laliberte F, Yergey J. Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85 kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-chal-lenged platelets. J Biol Chem 1994; 269: 15619-15624
    PubMedGoogle Scholar
  • 14 Bartoli F, Lin H-K, Ghomashchi F, Gelb MH, Jain MK, Apitz-Castro R. Tight binding inhibitors of 85 kDa phospholipase A2 but not 14-kDa phospholipase A2 inhibit release of free arachidonate in thrombin-stimulated human platelets. J Biol Chem 1994; 269: 15625-15630
    PubMedGoogle Scholar
  • 15 Glover S, Bayburt T, Mechthild J, Chi E, Gelb MH. Translocation of the 85-kDa phospholipase A2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen. J Biol Chem 1995; 270: 15359-15367
    CrossrefPubMedGoogle Scholar
  • 16 Schievella AR, Regier MK, Smith WL, Lin L-L. Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum. J Biol Chem 1995; 270: 30749-30754
    CrossrefPubMedGoogle Scholar
  • 17 Herschman HR. Regulation of prostaglandin synthase-1 and prostaglandin synthase-2. Can Metastasis Rev 1994; 13: 241-256
    PubMedGoogle Scholar
  • 18 Kamp F, Hamilton JA. Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers. Biochemistry 1993; 32: 11074-11085
    CrossrefPubMedGoogle Scholar
  • 19 Rollins TE, Smith WL. Subcellular localization of prostaglandin-forming cyclooxygenase in Swiss mouse 3T3 fibroblasts by electron microscopic immunocytochemistry. J Biol Chem 1980; 255: 4872-4875
    PubMedGoogle Scholar
  • 20 Regier MK, DeWitt DL, Schindler MS, Smith WL. Subcellular localization of prostaglandin endoperoxide synthase-2 in murine 3T3 cells. Arch Biochem Biophys 1993; 301: 439-144
    CrossrefPubMedGoogle Scholar
  • 21 Otto JC, Smith WL. The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum. J Biol Chem 1994; 269: 19868-19875
    PubMedGoogle Scholar
  • 22 Ruan K-H, Wang L-H, Wu KK, Kulmacz RJ. Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum. J Biol Chem 1993; 268: 19483-19490
    PubMedGoogle Scholar
  • 23 Tanaka Y, Ward SL, Smith WL. Immunochemical and kinetic evidence for two different prostaglandin H-prostaglandin E isomerases in sheep vesicular gland microsomes. J Biol Chem 1987; 262: 1374-1381
    PubMedGoogle Scholar
  • 24 Smith WL. Prostanoid biosynthesis and mechanisms of action. Am J Physiol 1992; 263 (2 Pt 2): F181-F191
    PubMedGoogle Scholar
  • 25 Bito LZ, Baroody RA. Impermeability of rabbit erythrocytes to prostaglandins. Amer J Physiol 1974; 229: 1580-1586
    PubMedGoogle Scholar
  • 26 Garcia-Perez A, Smith WL. Apical-basolateral membrane asymmetry in canine cortical collecting tubule cells: bradykinin, AVP,PGE2 interrelationships. J Clin Invest 1984; 744: 63-74
    PubMedGoogle Scholar
  • 27 Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW, Schuster VL. Identification and characterization of a prostaglandin transporter. Science 1995; 268: 866-869
    CrossrefPubMedGoogle Scholar
  • 28 Gorman RR, Fitzpatrick FA, Miller VO. Reciprocal regulation of human platelet cAMP levels by thromboxane A2 and prostacyclin. In: George WW, Ignarro LJ. editors. Advances in Cyclic Nucleotide Research, v. 9. NY: Raven Press; 1978: 597-609
    Google Scholar
  • 29 Grantham JJ, Orloff J. Effect of prostaglandin El on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3',5'-monophosphate, and theophylline. J Clin Invest 1968; 47: 1154-1161
    CrossrefPubMedGoogle Scholar
  • 30 Coleman RA, Smith WL, Narumiya S. Classification of prostanoid receptors: properties, distribution and structure of the receptors and their subtypes. Pharm Rev 1994; 46: 205-229
    PubMedGoogle Scholar
  • 31 Ushikubi F, Hirata M, Narumiya S. Molecular biology of prostanoid receptors; an overview. JLipid Mediat 1995; 12: 343-359
    PubMedGoogle Scholar
  • 32 Habenicht AJR, Goerig M, Grulich J, Rothe D, Gronwald R, Loth U. et al. Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase. J Clin Invest 1985; 75: 1381-1387
    CrossrefPubMedGoogle Scholar
  • 33 Raz A, Wyche A, Siegel N, Needleman P. Regulation of fibroblast cyclooxygenase synthesis by interleukin-1. J Biol Chem 1988; 263: 3022-3028
    PubMedGoogle Scholar
  • 34 Lin AH, Bienkowski MJ, Gorman RR. Regulation of prostaglandin H synthase mRNA levels and prostaglandin biosynthesis by platelet-derived growth factor. J Biol Chem 1989; 264: 17379-17383
    PubMedGoogle Scholar
  • 35 Evett GE, Xie W, Chipman JG, Robertson DL, Simmons DL. Prostaglandin G/H isoenzyme 2 expression in fibroblasts: regulation by dexamethasone, mitogens, and oncogenes. Arch Biochem Biophys 1993; 306: 169-177
    CrossrefPubMedGoogle Scholar
  • 36 DeWitt DL, Meade EA. Serum and glucocorticoid regulation of gene transcription and expression of the prostaglandin H synthase-1 and prostaglandin H synthase-2 isozymes. Arch Biochem Biophys 1993; 306: 094-102
    CrossrefPubMedGoogle Scholar
  • 37 Lee SH, Soyoola E, Chanmugam P, Hart S, Sun W, Zhong H. et al. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 1992; 267: 25934-25938
    CrossrefPubMedGoogle Scholar
  • 38 Nalefski AE, Sultzman LA, Martin DM, Kriz RW, Towler PS, Knopf JL. et al. Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca2+-de-pendent lipid-binding domain and a Ca2+-independent catalytic domain. J Biol Chem 1994; 269: 18239-18249
    PubMedGoogle Scholar
  • 39 Balsinde J, Barbour SE, Bianco ID, Dennis EA. Arachidonic acid mobilization in P388D1 macrophages is controlled by two distinct Ca(2+)-dependent phospholipase A2 enzymes. Proc Natl Acad Sci U S A 1994; 91: 11060-11064
    CrossrefPubMedGoogle Scholar
  • 40 Barbour SE, Dennis EA. Antisense inhibition of Group II phospholipase A2 expression blocks the production of prostaglandin E2 by P388D1 cells. J Biol Chem 1993; 268: 21875-21882
    PubMedGoogle Scholar
  • 41 Hoeck WG, Ramesha CS, Chang DJ, Fan N, Heller RA. Cytoplasmic phospholipase A2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced synthesis. Proc Natl Acad Sci USA 1993; 90: 4475-4479
    CrossrefPubMedGoogle Scholar
  • 42 Hulkower KI, Wertheimer SJ, Levin W, Coffey JW, Anderson CM, Chen T. et al. Interleukin-1 beta induces cytosolic phospholipase A2 and prostaglandin H synthase in rheumatoid synovial fibroblasts: evidence for their roles in the production of prostaglandin E2. Arthritis Rheum 1994; 37: 653-661
    CrossrefPubMedGoogle Scholar
  • 43 Roshak A, Sathe G, Marshall LA. Suppression of monocyte 85-kDa phospholipase A2 by antisense and effects on endotoxin-induced prostaglandin biosynthesis. J Biol Chem 1994; 269: 25999-26005
    PubMedGoogle Scholar
  • 44 Chepenik KP, Diaz A, Jimenez SA. Epidermal growth factor coordinately regulates the expression of prostaglandin G/H synthase and cytosolic phospholipase A2 genes in embryonic mouse cells. J Biol Chem 1994; 269: 21786-21792
    PubMedGoogle Scholar
  • 45 Doerfler ME, Weiss J, Clark JD, Elsbach P. Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kD cytosolic phospholipase A2. J Clin Invest 1994; 93: 1583-1591
    CrossrefPubMedGoogle Scholar
  • 46 Marshall LA, Bolognese B, Roshak A. Characterization of phospholipase A2releaseby elicited-peritonealmacrophageandits relationship toeicosanoidproduction. JLipidMed 1994; 10: 295-313
    PubMedGoogle Scholar
  • 47 Angel J, Berenbaum F, Le-Denmat C, Nevalainen T, Masliah J, Fournier C. Interleukin-1-induced prostaglandin E2 biosynthesis in human synovial cells involves the activation of cytosolic phospholipase A2 and cyclooxygenase-2. Eur J Biochem 1994; 226: 125-131
    CrossrefPubMedGoogle Scholar
  • 48 Schaefers JH, Haselmann J, Goppelt-Struebe M. Regulation of prostaglandin synthesis in Madin Darby canine kidney cells: role of prostaglandin G/H synthase and secreted phospholipase A2. Biochim Biophys Acta. 1995 in press
    PubMedGoogle Scholar
  • 49 Smith WL, DeWitt DL, Allen ML. Bimodal distribution of the prostaglandin 12 synthase antigen in smooth muscle cells. J Biol Chem 1983; 258: 5922-5926
    PubMedGoogle Scholar
  • 50 Jones DA, Carlton DP, McIntyre TM, Zimmerman GA, Prescott SM. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J Biol Chem 1993; 268: 9049-9054
    PubMedGoogle Scholar
  • 51 Rao CV, Mitra SB. Distribution of PGE and PGF2a receptor proteins in the intracellular organelles of bovine corpora lutea. Methods Enzymol 1982; 86: 192-202
    PubMedGoogle Scholar
  • 52 Namba T, Sugimoto Y, Negishi M, Irie A, Ushikubi F, Kakizuka A. et al. Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity [see comments]. Nature 1993; 365: 166-170
    CrossrefPubMedGoogle Scholar
  • 53 Forman BM, Tontonoz P, Chen J, Brun R, Spiegelman BM, Evans RM. 15-Deoxy-delta-12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR- gamma. Cell 1995; 83: 803-812
    CrossrefPubMedGoogle Scholar
  • 54 Tontonoz P, Hu E, Graves RA, Budavari Al, Spiegelman BM. mPPARgamma2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 1994; 08: 1224-1234
    CrossrefPubMedGoogle Scholar
  • 55 DeWitt DL, Smith WL. Primary structure of prostaglandin G/ H synthase from sheep vesicular gland determined from the complementary DNA sequence. Proc Natl Acad Sci USA 1988; 85: 1212-1416
    PubMedGoogle Scholar
  • 56 Sirois J, Richards JS. Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles. J Biol Chem 1992; 267: 6382-6388
    PubMedGoogle Scholar
  • 57 Nothwehr SF, Stevens TH. Sorting of membrane proteins in the yeast secretory pathway. J Biol Chem 1994; 269: 10185-10188
    PubMedGoogle Scholar
  • 58 Pelham HRB. The retention signal for soluble proteins of the endoplasmic reticulum. TIBS 1990; 15: 483-485
    PubMedGoogle Scholar
  • 59 Tang BL, Wong SH, Low SH, Hong W. Retention of a Type II surface membrane protein in the endoplasmic reticulum by the Lys-Asp-Glu-Leu sequence. J Biol Chem 1992; 267: 7072-7076
    PubMedGoogle Scholar
  • 60 Regier MK, Otto JC, DeWitt DL, Smith WL. Localization of Prostaglandin Endoperoxide Synthase-1 to the Endoplasmic Reticulum and Nuclear Envelope is Independent of Its C-terminal Tetrapeptide-PTEL. Arch Biochem Biophys 1995; 317: 457-463
    CrossrefPubMedGoogle Scholar
  • 61 Ren Y, Loose-Mitchell DS, Kulmacz RJ. Prostaglandin H synthase-1: evaluation of C-terminus function. Arch Biochem Biophys 1995; 316: 751-757
    CrossrefPubMedGoogle Scholar
  • 62 Song I, Smith WL. C-terminal Ser/Pro-Thr-Glu-Leu tetrapeptides of prostaglandin endoperoxide H synthases-1 and -2 target the enzymes to the endoplasmic reticulum. Arch Biochem Biophys 1996; 334: 67-72
    CrossrefPubMedGoogle Scholar
  • 63 Munro S, Pelham HRB. AC-terminal signal prevents secretion of luminal ER proteins. Cell 1987; 48: 899-907
    CrossrefPubMedGoogle Scholar