DOI: 10.1055/s-00035024

Thrombosis and Haemostasis

Issue 08 · Volume 82 · 1999 DOI: 10.1055/s-008-36048

Research Article

  • 165
    Mann, Kenneth G.:

    Biochemistry and Physiology of Blood Coagulation

  • 175
    Ruf, Wolfram; Mueller, Barbara M.:

    Tissue Factor Signaling

  • 183
    Prydz, Hans; Camerer, Eric; Røttingen, John-Arne; Wiiger, Merete Thune; Gjernes, Elisabet:

    Cellular Consequences of the Initiation of Blood Coagulation

  • 193
    Fay, Philip J.:

    Regulation of Factor VIIIa in the Intrinsic Factor Xase

  • 201
    Kaufman, Randal J.; Pipe, Steven W.:

    Regulation of Factor VIII Expression and Activity by von Willebrand Factor

  • 209
    Mertens, Koen; Celie, Patrick H.N.; Kolkman, Joost A.; Lenting, Peter J.:

    Factor VIII-Factor IX Interactions: Molecular Sites Involved in Enzyme-Cofactor Complex Assembly

  • 218
    Bajaj, S. Paul:

    Region of Factor IXa Protease Domain that Interacts with Factor VIIIa: Analysis of Select Hemophilia B Mutants

  • 226
    Schmaier, Alvin H.; Røjkjær, Rasmus; Shariat-Madar, Zia:

    Activation of the Plasma Kallikrein/Kinin System on Cells: A Revised Hypothesis

  • 234
    Walsh, Peter N.:

    Platelets and Factor XI Bypass the Contact System of Blood Coagulation

  • 243
    Bouma, Bonno N.; Meijers, Joost C.M.:

    Fibrinolysis and the Contact System: A Role for Factor XI in the Down-Regulation of Fibrinolysis

  • 251
    Esmon, Charles T.; Xu, Jun; Gu, Jian-ming; Qu, Dongfeng; Laszik, Zolton; Ferrell, Gary; Stearns-Kurosawa, Deborah J.; Kurosawa, Shichiro; Taylor, Fletcher B.; Esmon, Naomi L.:

    Endothelial Protein C Receptor

  • 259
    Collen, Désiré:

    The Plasminogen (Fibrinolytic) System

  • 271
    Doolittle, Russell F.; Spraggon, Glen; Everse, Stephen J.:

    Crystal Structures of Fragments D and Double-D from Fibrinogen and Fibrin

  • 277
    Weisel, John W.; Veklich, Yuri; Collet, Jean-Philippe; Francis, Charles W.:

    Structural Studies of Fibrinolysis by Electron and Light Microscopy

  • 283
    Matsuda, Michio; Sugo, Teruko; Yoshida, Nobuhiko; Terukina, Shigeharu; Yamazumi, Kensuke; Niwa, Kazuki; Maekawa, Hisato:

    Structure and Function of Fibrinogen: Insights from Dysfibrinogens

  • 291
    Chapman, Harold A.; Wei, Ying; Simon, Daniel I.; Waltz, David A.:

    Role of Urokinase Receptor and Caveolin in Regulation of Integrin Signaling

  • 298
    Blasi, Francesco:

    Proteolysis, Cell Adhesion, Chemotaxis, and Invasiveness Are Regulated by the u-PA-u-PAR-PAI-1 System

  • 305
    Koshelnick, Yuri; Ehart, Monika; Stockinger, Hannes; Binder, Bernd R.:

    Mechanisms of Signaling through Urokinase Receptor and the Cellular Response

  • 312
    Kaushansky, Kenneth:

    Thrombopoietin: From Theory to Reality

  • 318
    Shattil, Sanford J.:

    Signaling Through Platelet Integrin αIIbβ3: Inside-out, Outside-in, and Sideways

  • 326
    Coller, Barry S.:

    Binding of Abciximab to αVβ3 and Activated αMβ2 Receptors: With a Review of Platelet-Leukocyte Interactions

  • 337
    Bray, Paul F.:

    Integrin Polymorphisms as Risk Factors for Thrombosis

  • 345
    Law, Debbie A.; Nannizzi-Alaimo, Lisa; Cowan, Kyra J.; Prasad, K. S. Srinivasa; Ramakrishnan, Vanitha; Phillips, David R.:

    Signal Transduction Pathways for Mouse Platelet Membrane Adhesion Receptors

  • 353
    Coughlin, Shaun R.:

    Protease-Activated Receptors and Platelet Function

  • 357
    Andrews, Robert K.; Shen, Yang; Gardiner, Elizabeth E.; Dong, Jing-fei; López, José A.; Berndt, Michael C.:

    The Glycoprotein Ib-IX-V Complex in Platelet Adhesion and Signaling

  • 365
    Watson, Steve P.:

    Collagen Receptor Signaling in Platelets and Megakaryocytes

  • 377
    Oda, Atsushi; Miyakawa, Yoshitaka; Druker, Brian J.; Ozaki, Katsutoshi; Ohashi, Hideya; Kato, Takashi; Miyazaki, Hiroshi; Handa, Makoto; Ikebuchi, Kenji; Ikeda, Yasuo:

    Thrombopoietin-Induced Signal Transduction and Potentiation of Platelet Activation

  • 385
    Fox, Joan E. B.:

    On the Role of Calpain and Rho Proteins in Regulating Integrin-induced Signaling

  • 392
    Hartwig, John H.; Barkalow, Kurt; Azim, Anser; Italiano, Joe:

    The Elegant Platelet: Signals Controlling Actin Assembly

  • 399
    Ma, Alice D.; Abrams, Charles S.:

    Pleckstrin Homology Domains and Phospholipid-Induced Cytoskeletal Reorganization

  • 407
    Manganiello, V. C.; Degerman, E.:

    Cyclic Nucleotide Phosphodiesterases (PDEs): Diverse Regulators of Cyclic Nucleotide Signals and Inviting Molecular Targets for Novel Therapeutic Agents

  • 412
    Haslam, Richard J.; Dickinson, Natalie T.; Jang, Elliott K.:

    Cyclic Nucleotides and Phosphodiesterases in Platelets

  • 424
    Rybalkin, Sergei D.; Bornfeldt, Karin E.:

    Cyclic Nucleotide Phosphodiesterases and Human Arterial Smooth Muscle Cell Proliferation

  • 435
    Ikeda, Yasuo:

    Antiplatelet Therapy Using Cilostazol, a Specific PDE3 Inhibitor

  • 439
    Warkentin, Theodore E.:

    Heparin-Induced Thrombocytopenia: A Clinicopathologic Syndrome

  • 448
    Visentin, Gian Paolo:

    Heparin-Induced Thrombocytopenia: Molecular Pathogenesis

  • 457
    Greinacher, Andreas:

    Treatment of Heparin-Induced Thrombocytopenia

  • 468
    Nurden, Alan T.:

    Inherited Abnormalities of Platelets

  • 481
    Hynes, Richard O.; Hodivala-Dilke, Kairbaan M.:

    Insights and Questions Arising from Studies of a Mouse Model of Glanzmann Thrombasthenia

  • 486
    Drohan, William N.; Cervenakova, Larisa:

    Safety of Blood Products: Are Transmissible Spongiform Encephalopathies (Prion Diseases) a Risk?

  • 494
    Chamberland, Mary E.:

    Surveillance for Bloodborne Infections

  • 500
    Gill, Joan Cox:

    The Role of Genetics in Inhibitor Formation

  • 505
    Lollar, Pete:

    Characterization of Factor VIII B-Cell Inhibitory Epitopes

  • 509
    Reding, M.T.; Wu, H.; Krampf, M.; Okita, D.K.; Diethelm-Okita, B.M.; Key, N.S.; Conti-Fine, B.M.:

    CD4+ T Cell Response to Factor VIII in Hemophilia A, Acquired Hemophilia, and Healthy Subjects

  • 516
    Lee, Christine:

    Recombinant Clotting Factors in the Treatment of Hemophilia

  • 525
    Ljung, Rolf C. R.:

    Prophylactic Infusion Regimens in the Management of Hemophilia

  • 531
    Hedner, Ulla:

    Treatment of Patients with Factor VIII and Factor IX Inhibitors with Special Focus on the Use of Recombinant Factor VIIa

  • 540
    Herzog, Roland W.; High, Katherine A.:

    Adeno-Associated Virus-Mediated Gene Transfer of Factor IX for Treatment of Hemophilia B by Gene Therapy

  • 547
    Kochanek, Stefan:

    Development of High-Capacity Adenoviral Vectors for Gene Therapy

  • 552
    Naldini, Luigi:

    In Vivo Gene Delivery by Lentiviral Vectors

  • 555
    Greengard, Judith S.; Jolly, Douglas J.:

    Animal Testing of Retroviral-Mediated Gene Therapy for Factor VIII Deficiency

  • 562
    Zhang, Wei-Wei; Josephs, Steven F.; Zhou, Jiemin; Fang, Xiangming; Alemany, Ramón; Balagué, Cristina; Dai, Yifan; Ayares, David; Prokopenko, Elena; Lou, Yan-Chun; Sethi, Erica; Hubert-Leslie, Debbie; Kennedy, Mark; Ruiz, Lulio; Rockow-Magnone, Shayna:

    Development And Application Of A Minimal-Adenoviral Vector System For Gene Therapy Of Hemophilia A

  • 572
    Lusher, Jeanne M.:

    Gene Therapy for Hemophilia A and B: Patient Selection and Follow-up, Requirements for a Cure

  • 576
    Ruggeri, Zaverio M.:

    Structure and Function of von Willebrand Factor

  • 585
    Ginsburg, David:

    Molecular Genetics of von Willebrand Disease

  • 592
    Furlan, Miha; Lämmle, Bernhard:

    Von Willebrand Factor in Thrombotic Thrombocytopenic Purpura

  • 601
    Bertina, Rogier M.:

    Molecular Risk Factors for Thrombosis

  • 610
    Rosendaal, F.R.:

    Risk Factors for Venous Thrombotic Disease

  • 620
    Ginsberg, Jeffrey S.:

    Thromboembolism and Pregnancy

  • 626
    Koh, Kwang Kon; Horne, McDonald K.; Cannon, Richard O.:

    Effects of Hormone Replacement Therapy on Coagulation, Fibrinolysis, and Thrombosis Risk in Postmenopausal Women

  • 634
    Brenner, Benjamin:

    Inherited Thrombophilia and Pregnancy Loss

  • 641
    Lockshin, Michael D.:

    Pregnancy Loss in the Antiphospholipid Syndrome

  • 649
    Rand, Jacob H.; Wu, Xiao-Xuan:

    Antibody-Mediated Disruption of the Annexin-V Antithrombotic Shield: A New Mechanism for Thrombosis in the Antiphospholipid Syndrome

  • 656
    Roubey, Robert A. S.:

    Immunology of the Antiphospholipid Syndrome: Antibodies, Antigens, and Autoimmune Response

  • 662
    Bovill, Edwin G.; Hasstedt, Sandra J.; Leppert, Mark F.; Long, George L.:

    Hereditary Thrombophilia as a Model for Multigenic Disease

  • 667
    Lowe, Gordon D.O.; Rumley, Ann:

    Use Of Fibrinogen and Fibrin D-Dimer in Prediction of Arterial Thrombotic Events

  • 673
    Dempfle, Carl-Erik:

    The Use of Soluble Fibrin in Evaluating the Acute and Chronic Hypercoagulable State

  • 684
    Toh, Cheng Hock:

    APTT Revisited: Detecting Dysfunction in the Hemostatic System Through Waveform Analysis

  • 688
    Brill-Edwards, Patrick; Lee, Agnes:

    D-Dimer Testing in the Diagnosis of Acute Venous Thromboembolism

  • 695
    Levi, Marcel; de Jonge, Evert; van der Poll, Tom; ten Cate, Hugo:

    Disseminated Intravascular Coagulation

  • 706
    Müller-Berghaus, Gert; ten Cate, Hugo; Levi, Marcel:

    Disseminated Intravascular Coagulation: Clinical Spectrum and Established as well as New Diagnostic Approaches

  • 713
    ten Cate, Hugo; Timmerman, Janneke J.; Levi, Marcel:

    The Pathophysiology of Disseminated Intravascular Coagulation

  • 718
    Maruyama, Ikuro:

    Recombinant Thrombomodulin and Activated Protein C in the Treatment of Disseminated Intravascular Coagulation

  • 722
    Gimbrone, Michael A.:

    Endothelial Dysfunction, Hemodynamic Forces, and Atherosclerosis

  • 727
    Freyssinet, Jean-Marie; Toti, Florence; Hugel, Bénédicte; Gidon-Jeangirard, Carole; Kunzelmann, Corinne; Carmen Martínez, M.; Meyer, Dominique:

    Apoptosis in Vascular Disease

  • 736
    Libby, Peter; Mach, François; Schönbeck, Uwe; Bourcier, Todd; Aikawa, Masanori:

    Regulation of the Thrombotic Potential of Atheroma

  • 742
    Samad, Fahumiya; Loskutoff, David J.:

    Hemostatic Gene Expression and Vascular Disease in Obesity: Insights from Studies of Genetically Obese Mice

  • 748
    Friesel, R.; Maciag, T.:

    Fibroblast Growth Factor Prototype Release and Fibroblast Growth Factor Receptor Signaling

  • 755
    Dejana, Elisabetta; Bazzoni, Gianfranco; Lampugnani, Maria Grazia:

    The Role of Endothelial Cell-to-Cell Junctions in Vascular Morphogenesis

  • 762
    Yee, Karen O.; Schwartz, Stephen M.:

    Why Atherosclerotic Vessels Narrow: The Fibrin Hypothesis

  • 772
    Helisch, Armin; Anthony Ware, J.:

    Therapeutic Angiogenesis in Ischemic Heart Disease

  • 781
    Altieri, Dario C.:

    Regulation of Leukocyte-Endothelium Interaction by Fibrinogen

  • 787
    Cerletti, Chiara; Evangelista, Virgilio; de Gaetano, Giovanni:

    P-Selectin-β2-Integrin Cross-Talk: A Molecular Mechanism For Polymorphonuclear Leukocyte Recruitment At The Site Of Vascular Damage

  • 794
    Barry, Orla P.; FitzGerald, Garret A.:

    Mechanisms of Cellular Activation by Platelet Microparticles

  • 801
    Taubman, Mark B.; Giesen, Peter L.A.; Schecter, Alison D.; Nemerson, Yale:

    Regulation of the Procoagulant Response to Arterial Injury

  • 806
    Koyama, Hiroyuki; Eric Olson, N.; Reidy, Michael A.:

    Cell Signaling in Injured Rat Arteries

  • 810
    Berk, Bradford C.:

    Redox Signals that Regulate the Vascular Response to Injury

  • 818
    Humphries, Steve E.; Luong, Le-Anh; Montgomery, Hugh E.; Day, Ian N.M.; Mohamed-Ali, Vidya; Yudkin, John S.:

    Gene-Environment Interaction in the Determination of Levels of Plasma Fibrinogen

  • 826
    Tracy, Russell P.:

    Epidemiological Evidence for Inflammation in Cardiovascular Disease

  • 832
    Juhan-Vague, I.; Alessi, M.C.:

    Regulation of Fibrinolysis in the Development of Atherothrombosis: Role of Adipose Tissue

  • 837
    Lijnen, H.R.; Collen, D.:

    Matrix Metalloproteinase System Deficiencies and Matrix Degradation

  • 846
    Shapiro, Steven D.:

    Diverse Roles of Macrophage Matrix Metalloproteinases in Tissue Destruction and Tumor Growth

  • 850
    Hartwell, Daqing W.; Wagner, Denisa D.:

    New Discoveries with Mice Mutant in Endothelial and Platelet Selectins

  • 858
    Degen, Jay L.:

    Hemostatic Factors and Inflammatory Disease

  • 865
    Sato, Thomas N.:

    Gene Trap, Gene Knockout, Gene Knock-In, and Transgenics in Vascular Development

  • 870
    Bates, Shannon M.; Hirsh, Jack:

    Treatment of Venous Thromboembolism

  • 878
    Anderson, David R.; Wells, Philip S.:

    Improvements in the Diagnostic Approach for Patients with Suspected Deep Vein Thrombosis or Pulmonary Embolism

  • 887
    Kearon, Clive:

    Initial Treatment of Venous Thromboembolism

  • 892
    Prins, Martin H.; Hutten, Barbara A.; Koopman, Maria M.W.; Büller, Harry R.:

    Long-Term Treatment of Venous Thromboembolic Disease

  • 899
    Goldhaber, Samuel Z.:

    Venous Thromboembolism Prophylaxis in Medical Patients

  • 902
    Dahl, Ola E.:

    Mechanisms of Hypercoagulability

  • 907
    Torbicki, Adam:

    Imaging Venous Thromboembolism with Emphasis on Ultrasound, Chest CT, Angiography and Echocardiography

  • 913
    Thompson, Gale E.:

    Anticoagulation in the Setting of Epidural or Spinal Anesthesia/Analgesia

  • 918
    Pineo, G.F; Hull, R.D.:

    Prophylaxis of Venous Thromboembolism Following Orthopedic Surgery: Mechanical and Pharmacological Approaches and the Need for Extended Prophylaxis

  • 925
    Agnelli, Giancarlo:

    Prevention of Venous Thromboembolism After Neurosurgery

  • 931
    Bounameaux, Henri:

    Integrating Pharmacologic and Mechanical Prophylaxis of Venous Thromboembolism

  • 938
    del Zoppo, Gregory J.:

    Antithrombotic Treatments in Acute Ischemic Stroke

  • 947
    Hettiarachchi, Rohan J.K.; Smorenburg, Susanne M.; Ginsberg, Jeffrey; Levine, Mark; Prins, Martin H.; Büller, Harry R.:

    Do Heparins Do More than Just Treat Thrombosis? The Influence of Heparins on Cancer Spread

  • 953
    Gulba, Dietrich C.:

    Do Interventions Provide Additional Benefit to Drug Treatment of Acute Coronary Syndromes? A Call for a Reserved, Watchful Approach

  • 962
    May, Andreas E.; Neumann, Franz-Josef; Preissner, Klaus T.:

    The Relevance of Blood Cell-Vessel Wall Adhesive Interactions for Vascular Thrombotic Disease

  • 971
    van de Loo, Jürgen C.W.:

    Historical Perspectives on Thrombolytic Therapy

  • 974
    Weitz, Jeffrey I.; Stewart, Ronald J.; Fredenburgh, James C.:

    Mechanism of Action of Plasminogen Activators

  • 983
    Hacke, Werner; Ringleb, Peter; Stingele, Robert:

    Thrombolysis in Acute Cerebrovascular Disease: Indications and Limitations

  • 987
    Kandarpa, Krishna:

    Catheter-Directed Thrombolysis of Peripheral Arterial Occlusions and Deep Vein Thrombosis

  • 997
    Badimon, Juan Jose; Zaman, Azfar; Helft, Gerard; Fayad, Zahi; Fuster, Valentin:

    Acute Coronary Syndromes: Pathophysiology and Preventive Priorities