Thromb Haemost 1999; 82(02): 175-182
DOI: 10.1055/s-0037-1615831
Research Article
Schattauer GmbH

Tissue Factor Signaling

Wolfram Ruf
1   Departments of Immunology and Vascular Biology, The Scripps Research Institute, La Jolla, CA, USA
,
Barbara M. Mueller
1   Departments of Immunology and Vascular Biology, The Scripps Research Institute, La Jolla, CA, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
09 December 2017 (online)

 

 
  • References

  • 1 Ruf W, Edgington TS. Structural biology of tissue factor, the initiator of thrombogenesis in vivo. FASEB J. 1994; 8: 385-390.
  • 2 Banner DW, D’Arcy A, Chène C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 1996; 380: 41-46.
  • 3 Bazan JF. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA. 1990; 87: 6934-6938.
  • 4 Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Silvennoinen O. Signaling through the hematopoietic cytokine receptors. Ann Rev Immunol. 1995; 13: 369-398.
  • 5 Zioncheck TF, Roy S, Vehar GA. The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism. J Biol Chem. 1992; 267: 3561-3564.
  • 6 Mody RS, Carson SD. Tissue factor cytoplasmic domain peptide is multiply phosphorylated in vitro. Biochemistry. 1997; 36: 7869-7875.
  • 7 Roy S, Paborsky LR, Vehar GA. Self-association of tissue factor as revealed by chemical cross-linking. J Biol Chem. 1991; 266: 4665-4668.
  • 8 Bach RR, Moldow CF. Mechanism of tissue factor activation on HL-60 cells. Blood 1997; 89: 3270-3276.
  • 9 Drake TA, Ruf W, Morrissey JH, Edgington TS. Functional tissue factor is entirely cell surface expressed on lipopolysaccharide-stimulated human blood monocytes and a constitutively tissue factor-producing neoplastic cell line. J Cell Biol. 1989; 109: 389-395.
  • 10 Sevinsky JR, Rao LVM, Ruf W. Ligand-induced protease receptor translocation into caveolae: A mechanism for regulating cell surface proteolysis of the tissue factor-dependent coagulation pathway. J Cell Biol. 1996; 133: 293-304.
  • 11 Mulder AB, Smit JW, Bom VJJ, Blom NR, Ruiters MHJ, Halie MR, van der Meer J. Association of smooth muscle cell tissue factor with caveolae. Blood 1996; 88: 1306-1313.
  • 12 Müller M, Flössel C, Haase M, Luther T, Albrecht S, Nawroth PP, Zhang Y. Cellular localization of tissue factor in human breast cancer cell lines. Virchows Arch B Cell Pathol. 1993; 64: 265-269.
  • 13 Carson SD, Perry GA, Pirruccello SJ. Fibroblast tissue factor: Calcium and ionophore induce shape changes, release of membrane vesicles, and redistribution of tissue factor antigen in addition to increased procoagulant activity. Blood 1994; 84: 526-534.
  • 14 Carson SD. Manifestation of cryptic fibroblast tissue factor occurs at detergent concentrations which dissolve the plasma membrane. Blood Coagul Fibrinolysis. 1996; 7: 303-313.
  • 15 Sargiacomo M, Sudol M, Tang Z, Lisanti M. Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells. J Cell Biol. 1993; 122: 789-807.
  • 16 Rottingen JA, Enden T, Camerer E, Iversen J, Prydz H. Binding of human factor VIIa to tissue factor induces cytosolic Ca2+ signals in J82 cells, transfected COS-1 cells, MDCK cells and in human endothelial cells induced to synthesize tissue factor. J Biol Chem. 1995; 270: 4650-4660.
  • 17 Poulsen LK, Jacobsen N, Sorensen BB, Bergenhem NCH, Kelly JD, Foster DC, Thastrup O, Ezban M, Petersen LC. Signal transduction via the mitogen-activated protein kinase pathway induced by binding of coagulation factor VIIa to tissue factor. J Biol Chem. 1998; 273: 6228-6232.
  • 18 Pendurthi UR, Alok D, Rao LVM. Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: Up-regulation of poly(A) polymerase. Proc Natl Acad Sci USA. 1997; 94: 12598-12603.
  • 19 Taniguchi T, Kakkar AK, Tuddenham EGD, Williamson RCN, Lemoine NR. Enhanced expression of urokinase receptor induced through the tissue factor-factor VIIa pathway in human pancreatic cancer. Cancer Res. 1998; 58: 4461-4467.
  • 20 Ollivier V, Bentolila S, Chabbat J, Hakim J, De Prost D. Tissue-factor-dependent vascular endothelial growth factor production by human fibroblasts in response to activated factor VII. Blood 1998; 91: 2698-2703.
  • 21 Masuda M, Nakamura S, Murakami T, Komiyama Y, Takahashi H. Association of tissue factor with a gamma chain homodimer of the IgE receptor type I in cultured human monocytes. Eur J Immunol. 1996; 26: 2529-2532.
  • 22 Dickinson CD, Ruf W. Active site modification of factor VIIa affects interactions of the protease domain with tissue factor. J Biol Chem. 1997; 272: 19875-19879.
  • 23 Camerer E, Rottingen JA, Iversen J-G, Prydz H. Coagulation factors VII and X induce Ca2+ oscillations in madin-darby canine kidney cells only when proteolytically active. J Biol Chem. 1996; 271: 29034-29042.
  • 24 Sato Y, Asada Y, Marutsuka K, Hatakeyama K, Kamikubo Y, Sumiyoshi A. Tissue factor pathway inhibitor inhibits aortic smooth muscle cell migration induced by tissue factor-factor VIIa complex. Thromb Haemost. 1997; 78: 1138-1141.
  • 25 Ruf W. The interaction of factor VIIa with tissue factor: Insight into the mechanism of cofactor-mediated activation of factor VIIa. Blood Coagul Fibrinolysis. 1998; 9: S73-S78.
  • 26 Dickinson CD, Kelly CR, Ruf W. Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa. Proc Natl Acad Sci USA. 1996; 93: 14379-14384.
  • 27 Huber R, Bode W. Structural basis of the activation and action of trypsin. Accounts of Chemical Research. 1978; 11: 114-122.
  • 28 Ruf W, Dickinson CD. Allosteric regulation of the cofactor-dependent serine protease coagulation factor VIIa. Trends Cardiovasc Med. 1998; 8: 350-356.
  • 29 Mueller BM, Reisfeld RA, Edgington TS, Ruf W. Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis. Proc Natl Acad Sci USA. 1992; 89: 11832-11836.
  • 30 Mueller BM, Ruf W. Requirement for binding of catalytically active factor VIIa in tissue factor dependent experimental metastasis. J Clin Invest. 1998; 101: 1372-1378.
  • 31 Fischer EG, Ruf W, Mueller BM. Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells. Cancer Res 1995; 55: 1629-1632.
  • 32 Bromberg ME, Konigsberg WH, Madison JF, Pawashe A, Garen A. Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation. Proc Natl Acad Sci USA. 1995; 92: 8205-8209.
  • 33 Sorensen BB, Freskgard P-O, Rao LVM, Ezban M, Petersen LC. FVIIa-induced signal transduction via the p44/42 MAPK pathway depends on the proteolytic activity of FVIIa, the cytoplasmic domain of TF is not required. Blood 1998; 92: 170a-170a.
  • 34 Ott I, Fischer EG, Miyagi Y, Mueller BM, Ruf W. A role for tissue factor in cell adhesion and migration mediated by interaction with actin binding protein 280. J Cell Biol. 1998; 140: 1241-1253.
  • 35 Gorlin JB, Yamin R, Egan S, Stewart M, Stossel TP, Kwiatkowski DJ, Hartwig JH. Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): A molecular leaf spring. J Cell Biol. 1990; 111: 1089-1105.
  • 36 Takafuta T, Wu G, Murphy GF, Shapiro SS. Human β-filamin is a new protein that interacts with the cytoplasmic tail or glycoprotein Ibα. J Biol Chem. 1998; 273: 17531-17538.
  • 37 Xu W-F, Xie Z-W, Chung DW, Davie EW. A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibα. Blood 1998; 92: 1268-1276.
  • 38 Xie Z-W, Xu W-F, Davie EW, Chung DW. Molecular cloning of human ABPL, an actin-binding protein homologue. Biochem Biophys Res Commun. 1998; 251: 914-919.
  • 39 Cunningham CC, Gorlin JB, Kwiatkowski DJ, Hartwig JH, Janmey PA, Byers HR, Stossel TP. Actin-binding protein requirement for cortical stability and efficient locomotion. Science 1992; 255: 325-327.
  • 40 Marti A, Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel TP, Kyriakis JM, Avruch J. Actin-biding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-α activation of SAPK in melanoma cells. J Biol Chem. 1997; 272: 2620-2628.
  • 41 Ilic D, Furuta Y, Kanazawa S, Takeda N, Sobue K, Nakatsu N, Nomura S, Fujimoto J, Okada M, Yamamoto T, Alzawa S. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 1995; 377: 543-544.
  • 42 Wei Y, Lukashev M, Simon DI, Bodary SC, Rosenberg S, Doyle MV, Chapman HA. Regulation of integrin function by the urokinase receptor. Science 1996; 273: 1551-1555.
  • 43 Randolph GJ, Luther T, Albrecht S, Magdolen V, Muller WA. Role of tissue factor in adhesion of mononuclear phagocytes to and trafficking through endothelium in vitro. Blood 1998; 92: 4167-4177.
  • 44 Carmeliet P, Mackman N, Moons L, Luther T, Gressens P, Van Vlaenderen I, Demunck H, Kasper M, Breier G, Evrard P, Müller M, Risau W, Edgington T, Collen D. Role of tissue factor in embryonic blood vessel development. Nature 1996; 383: 73-75.
  • 45 Bugge TH, Xiao Q, Kombrinck KW, Flick MJ, Holmbäck K, Danton HJS, Colbert MC, Witte DP, Fujikawa K, Davie EW, Degen JL. Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. Proc Natl Acad Sci USA. 1996; 93: 6258-6263.
  • 46 Toomey JR, Kratzer KE, Lasky NM, Stanton JJ, Broze Jr. GJ. Targeted disruption of the murine tissue factor gene results in embryonic lethality. Blood 1996; 88: 1583-1587.
  • 47 Parry GCN, Erlich JH, Mackman N. Human tissue factor protein lacking the cytoplasmic domain rescues murine tissue factor null embryos. Circulation. 1998; 98: I-40-I-40 (Abstract)
  • 48 Sato Y, Asada Y, Marutsuka K, Hatakeyama K, Sumiyoshi A. Tissue factor induces migration of cultured aortic smooth muscle cells. Thromb Haemost. 1996; 75: 389-392.
  • 49 Zhang Y, Deng Y, Luther T, Müller M, Ziegler R, Waldherr R, Stern DM, Nawroth PP. Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice. J Clin Invest. 1994; 94: 1320-1327.