DOI: 10.1055/s-00000083

Synlett

Issue 17 · Volume 36 · October 2025 DOI: 10.1055/s-015-62376

table of contents

  • V

    Linked PDF of Table of Contents

    • account

    Small Molecules in Medicinal Chemistry

  • 2671
    Tomohara, Keisuke; Nose, Takeru; Nambu, Hisanori:

    Straightforward Synthesis of Unnatural α,α-Disubstituted α-Amino Acid Derivatives Using Readily Accessible Building Blocks

    Image for article: Straightforward Synthesis of Unnatural α,α-Disubstituted α-Amino Acid Derivatives Using Readily Accessible Building Blocks
  • 2684
    Nazir, Habiba; Naseer, Muhammad Moazzam:

    The Isatin Scaffold: Exceptional Potential for the Design of Potent Bioactive Molecules

    Image for article: The Isatin Scaffold: Exceptional Potential for the Design of Potent Bioactive Molecules
  • 2705
    Kumar, Ankur; Debnath, Utsab; Roy, Kuldeep K.:

    Thiazole-Scaffold-Based Anti-tubercular Agents: A Review on Synthesis and Structural Modifications

    Image for article: Thiazole-Scaffold-Based Anti-tubercular Agents: A Review on Synthesis and Structural Modifications
  • 2732
    Khan, Tahmeena; Raza, Saman; Hashmi, Kulsum; Ahmad, Mohammad Imran; Khan, Abdul Rahman:

    Structural Modifications for Biological Activity Enhancements in Thiosemicarbazone Scaffolds and Their Metal Complexes

    Image for article: Structural Modifications for Biological Activity Enhancements in Thiosemicarbazone Scaffolds and Their Metal Complexes
  • 2763
    Martinez, Alice K. de A.; Mourão, Penina S.; Corrêa, Arlene G.:

    A Concise Account on Organocatalyzed Asymmetric Synthesis of Epoxide and Aziridine Derivatives from α,β-Unsaturated Carbonyl Compounds

    Image for article: A Concise Account on Organocatalyzed Asymmetric Synthesis of Epoxide and Aziridine Derivatives from α,β-Unsaturated Carbonyl Compounds
  • 2772
    Kumar, Ch. N. S. Sai Pavan; Jayathirtha, Vaidya Rao:

    Bioactive Molecules via Morita–Baylis–Hillman Chemistry

    Image for article: Bioactive Molecules <i>via</i> Morita–Baylis–Hillman Chemistry
  • 2791
    Purohit, Priyank; Bhatt, Akanksha; Mittal, Ravi Kumar:

    Ruthenium-Based Small-Molecule Complexes: A Promising Approach for Drug Discovery

    Image for article: Ruthenium-Based Small-Molecule Complexes: A Promising Approach for Drug Discovery

    • perspectives

    Small Molecules in Medicinal Chemistry

  • 2802
    Goel, Kapil Kumar; Singhal, Peeush; Marianesan, Arockia Babu; Pandey, Sarvesh Kumar; Kumar, Roshan; Singh, Thakur Gurjeet; Tyagi, Yogita; Gaidhane, Shilpa; Singh, Mahendra Pratap; Dwivedi, Ashish Ranjan:

    A Decade of Piperazine-Based Small Molecules Approved by U.S. FDA: Exploring the Medicinal Chemistry Impact of this Versatile Pharmacophore

    Image for article: A Decade of Piperazine-Based Small Molecules Approved by U.S. FDA: Exploring the Medicinal Chemistry Impact of this Versatile Pharmacophore
  • 2819
    Garg, Mansi; Verma, Ekta; Mishra, Shweta; Sahu, Adarsh:

    Advancements in Isoniazid-Based Heterocyclic Derivatives as Potent Antitubercular Agents: A Comprehensive Review of Synthesis, SAR, and Biological Activity (2017–2023)

    Image for article: Advancements in Isoniazid-Based Heterocyclic Derivatives as Potent Antitubercular Agents: A Comprehensive Review of Synthesis, SAR, and Biological Activity (2017–2023)
  • 2836
    Kushwaha, Pragati; Rashi, Rashi; Bhardwaj, Ayush; Khan, Danish:

    Advances in Synthesis and Anti-Alzheimer’s Disease Potential of Functionalized Benzofurans: A Recent Overview

    Image for article: Advances in Synthesis and Anti-Alzheimer’s Disease Potential of Functionalized Benzofurans: A Recent Overview

    • letter

    Small Molecules in Medicinal Chemistry

  • 2855
    Dastari, Sowmya; Panda, Biswajit; Rasane, Sai; Reddyrajula, Rajkumar; Godugu, Chandraiah; Shankaraiah, Nagula:

    Design, Synthesis, and In Vitro Cytotoxicity Studies of 1H-Benzimidazol-2-yl–Enaminone Hybrids as Tubulin Polymerization Inhibitors

    Image for article: Design, Synthesis, and In Vitro Cytotoxicity Studies of 1H-Benzimidazol-2-yl–Enaminone Hybrids as Tubulin Polymerization Inhibitors
    Supporting Information (PDF)
  • 2864
    Chakraborty, Kaustav; Dasgupta, Swagata; Pathak, Tanmaya:

    Pyrimidine Carboxylic Acids Linked through 1,4,5-Trisubstituted 1,2,3-Triazoles: Synthesis and RNase A Inhibition Studies

    Image for article: Pyrimidine Carboxylic Acids Linked through 1,4,5-Trisubstituted 1,2,3-Triazoles: Synthesis and RNase A Inhibition Studies
    Supporting Information (PDF)
  • 2869
    Saliba, Paul; Hurem, David; Begovic, Lila; McNulty, James:

    (Methylcarboxymethylene)tripropylphosphorane: A Stabilized Ylide for Rapid Formation of Methyl Vinyl Ketones and Applications in Medicinal Chemistry and Natural Product Synthesis

    Image for article: (Methylcarboxymethylene)tripropylphosphorane: A Stabilized Ylide for Rapid Formation of Methyl Vinyl Ketones and Applications in Medicinal Chemistry and Natural Product Synthesis
    Supporting Information (PDF)
  • 2876
    Chuchvera, Yaroslav O.; Korobka, Oleksandr P.; Horbatochkin, Yurii O.; Ostapchuk, Eugeniy N.; Popova, Maria V.; Shishkina, Svitlana V.; Volovenko, Yulian M.; Dobrydnev, Alexey V.:

    Synthesis of 5-Functionalized 1-(Hetero)Aryl-1,2-thiazine 1-Oxides through a CSIC Reaction Strategy

    Image for article: Synthesis of 5-Functionalized 1-(Hetero)Aryl-1,2-thiazine 1-Oxides through a CSIC Reaction Strategy
    Supporting Information (PDF)
  • 2883
    Okon, Aniekan; Morgunov, Anton; Yang, Jinyi; Petri, Yana D.; Kilgore, Henry R.; Li, Yanfeng; Strieter, Eric R.; Raines, Ronald T.:

    Hydrophilic α-Aryl-α-Diazoamides for Protein Esterification

    Image for article: Hydrophilic α-Aryl-α-Diazoamides for Protein Esterification
    Supporting Information (PDF)
  • 2890
    Pumirat, Pattarapon; Sripraphot, Supang; Nilchan, Napon; Jiarpinitnun, Chutima:

    Squaramide Homoserine Lactone Derivatives and their Abilities to Modulate Pseudomonas aeruginosa Biofilm Formation

    Image for article: Squaramide Homoserine Lactone Derivatives and their Abilities to Modulate <i>Pseudomonas aeruginosa</i> Biofilm Formation
    Supporting Information (PDF)
  • 2895
    Alzahrani, Abdullah Y. A.; El-Helw, Eman A. E.; Ramadan, Sayed K.:

    Some Thiazolopyrimidine Derivatives: Synthesis, DFT, Cytotoxicity, and Pharmacokinetics Modeling Study

    Image for article: Some Thiazolopyrimidine Derivatives: Synthesis, DFT, Cytotoxicity, and Pharmacokinetics Modeling Study
    Supporting Information (PDF) CSV File (OTHER)
  • 2906
    Gcabashe, Nontobeko; Kumar, Gobind; Seboletswe, Pule; Manhas, Neha; Singh, Parvesh:

    A Rapid, Greener, and Sustainable Synthesis of N-Acylhydrazones of Isoniazid in a Deep-Eutectic Solvent

    Image for article: A Rapid, Greener, and Sustainable Synthesis of <i>N</i>-Acylhydrazones of Isoniazid in a Deep-Eutectic Solvent
    Supporting Information (PDF)
  • 2915
    Sakamoto, Masaharu; Kai, Seriha; Tateishi, Hiroshi; Biswas, Tanima; Sakamoto, Takashi; Teshima, Misaki; Iwanaga, Misaki; Nishikawa, Akiko; Sakamoto, Arisa; Shimozono, Rie; Kameyama, Hiroki; Nambu, Masami; Masunaga, Takuya; Anraku, Kensaku; Fujita, Mikako; Otsuka, Masami:

    Oxaprozin and SB-431542 Hybrid Molecule Inhibits Fibrosis and Cancer Cell Migration

    Image for article: Oxaprozin and SB-431542 Hybrid Molecule Inhibits Fibrosis and Cancer Cell Migration
    Supporting Information (PDF)
  • 2920
    Seaton, Wesley B.; West, Clayton; Burke, Susan J.; Schilletter, William A.; Tade, Opeyemi O.; Collier, J. Jason; Campagna, Shawn R.:

    Design, Synthesis, and Biological Evaluation of Thioether Steroids as Glucocorticoid Receptor Modulators

    Image for article: Design, Synthesis, and Biological Evaluation of Thioether Steroids as Glucocorticoid Receptor Modulators
    Supporting Information (PDF)
  • 2925
    Thien, Nguyen Duc; Ngoc, Hoang Kim; Nam, Nguyen-Hai; Anh, Duong Tien; Baecker, Daniel:

    A Novel Strategy for the Synthesis of N-Alkylated Oxindoles

    Image for article: A Novel Strategy for the Synthesis of N-Alkylated Oxindoles
    Supporting Information (PDF)
  • 2930
    Rai, Aman; Soni, Arti; Bhatia, Rohit:

    Design, Synthesis, and Molecular Docking Studies of Sulfonyl-Substituted Chromene Derivatives as Anticancer Agents

    Image for article: Design, Synthesis, and Molecular Docking Studies of Sulfonyl-Substituted Chromene Derivatives as Anticancer Agents
    Supporting Information (PDF)
  • 2939
    Ateşoğlu, Şeyma; Çakır, Furkan; Şenol, Ayşe Merve; Tokalı, Pelin; Şenol, Halil; Tokalı, Feyzi Sinan; Akbaş, Fahri; Kalay, Erbay:

    Synthesis, Characterization and In Vitro and In Silico Biological Evaluation of New Mannich-Based Rhodanine and Thiazolidine-2,4-dione Derivatives as Potential Anti-Lung-Cancer Agents

    Image for article: Synthesis, Characterization and <i>In Vitro</i> and <i>In Silico</i> Biological Evaluation of New Mannich-Based Rhodanine and Thiazolidine-2,4-dione Derivatives as Potential Anti-Lung-Cancer Agents
    Supporting Information (PDF)
  • 2948
    Kobayakawa, Takuya; Yamamoto, Kenichi; Fukutome, Aiichiro; Arioka, Marisa; Tsuji, Kohei; Tamamura, Hirokazu:

    Design and Synthesis of a C2-Symmetric Cyclic Decapeptide and Its Peptidomimetic as Potential Inhibitors against Amyloid-β Aggregation

    Image for article: Design and Synthesis of a <i>C</i><sub>2</sub>-Symmetric Cyclic Decapeptide and Its Peptidomimetic as Potential Inhibitors against Amyloid-β Aggregation
    Supporting Information (PDF)
  • 2953
    Ghosh, Priyam; Mukhopadhyay, Sayantani; Singh, Mrinalini; Ghosh, Siddhartha Sankar; Iyer, Parameswar Krishnan:

    Exploring the Dual Therapeutic Potential of a Photoactivatable AIEgen in Cancer and Alzheimer’s Disease

    Image for article: Exploring the Dual Therapeutic Potential of a Photoactivatable AIEgen in Cancer and Alzheimer’s Disease
    Supporting Information (PDF) CIF File (OTHER)
  • 2960
    Chaudhury, Subhabrata; Wetzel, Edward A.; Elmansy, Mohamed F.; Hanson, Alicia M.; Brown-Ford, Sandra; Gleason, Alexandra; Perera, K. L. Iresha Sampathi; Sem, Daniel S.; Donaldson, William A.:

    Analogues of the Potent and Selective ERβ Agonist trans-4-(4-Hydroxyphenyl)cyclohexanemethanol: Synthesis and Evaluation

    Image for article: Analogues of the Potent and Selective ERβ Agonist <i>trans</i>-4-(4-Hydroxyphenyl)cyclohexanemethanol: Synthesis and Evaluation
    Supporting Information (PDF)
  • 2965
    Pranathi, Abburi Naga; Devendra, Nagineni; Behera, Prakash Suman; Swetha, Yalavarthi Sai; Vasapalli, Kanchana; Misra, Sunil; Sridhar, Balasubramanian; Kantevari, Srinivas:

    Three-Step Synthesis of 3-Aminoindole-2-carboxylate-Conjugated 2-Amino-6-chloropyrimidines and Their Anticancer Activity

    Image for article: Three-Step Synthesis of 3-Aminoindole-2-carboxylate-Conjugated 2-Amino-6-chloropyrimidines and Their Anticancer Activity
    Supporting Information (PDF)