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Synlett
DOI: 10.1055/a-2522-0970
DOI: 10.1055/a-2522-0970
perspective
Small Molecules in Medicinal Chemistry
Advances in Synthesis and Anti-Alzheimer’s Disease Potential of Functionalized Benzofurans: A Recent Overview
P.K. expresses gratitude to the Council of Science and Technology, U.P. (No. CST/D-795) and the University Grants Commission (UGC), New Delhi (F.30-507/2020(BSR)) for financial assistance.
Abstract
Alzheimer’s disease (AD) comes under progressive neurodegenerative disorders which is the leading cause of dementia affecting the aged population. The available drugs for AD treatment are just palliative and not curative, further these drugs have severe side effects. Therefore, there is a significant demand for novel, potent, and safe molecules as anti-Alzheimer’s disease agents with diverse mechanisms of action. Benzofuran derivatives are one of the versatile and ubiquitous scaffolds being developed as potential candidates against AD. While benzofuran analogues have not yet resulted in widely approved AD treatments, these molecules remain a significant focus of AD drug discovery because of their multitargeted approach and promising preclinical results. The ongoing research into these molecules holds potential for future clinical applications as anti-AD agents. In light of this, the present review outlined recent advances of the synthesis and potent anti-AD activities reported. The sole purpose of this review is to shed light on the design and development of these molecules with high efficacy and reduced toxicity against AD.
1 Introduction
2 Synthesis
3 Benzofuran-Based Scaffolds against AD
4 Naturally Occurring Benzofurans for Treatment of AD
5 Future Perspectives
6 Conclusion
Publication History
Received: 09 December 2024
Accepted after revision: 21 January 2025
Accepted Manuscript online:
21 January 2025
Article published online:
12 March 2025
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