Synthesis

Issue 15 · August 2025

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review
2261
Álvarez-Calero, José María; Horwitz, Matthew A.: Stereoselectivity Seems To Be the Hardest Word: Tracking the Evolution of Asymmetric API Syntheses from Medicinal Chemistry to Process Development

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short review
2278
Aida, Kazuhiro; Ota, Eisuke; Yamaguchi, Junichiro: Recent Advances in Single Electron Reduction Induced Ring Opening of N-Acyl Cyclic Amines

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2289
Ni, Qian; Chen, Yaqi; Ma, Yuanhong: Recent Progress in Base-Metal-Catalyzed Dearomative Reaction of N-Heteroarenes

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feature
2307
Li, Zihan; Li, Yichao; Zhang, Ruihao; Wang, Yuhao; Wang, Yilong; Yi, Ziqi; Huang, Yiyong: Chiral Phosphoric Acid Catalyzed Cascade Asymmetric Allylboration/Oxa-Cyclization of Aldehydes for Access to Multisubstituted Tetrahydrofurans

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Bürgenstock Special Section 2023 – Future Stars in Organic Chemistry
2320
Gupta, Neha; Deng, Hao; Ding, Huanyu; Qiu, Zihang; Neumann, Constanze N.: Rh(II)-Catalyzed Synthesis of 1,3-Diols via 5-endo-trig Cyclization of Silyl Radicals Open Access

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2331
Chen, Heng; Gurung, Sing R.; Li, Ling; Mancheno, Danny E.; Radtke, M. Alex; Ma, Zhou; Zhang, Zhi; Yang, Wuxing; Sun, Liang; Xie, Shiping: Development of an Efficient Synthesis toward a 4,4-Difluoropiperidine Intermediate Bearing a Pyridine N-Oxide Motif at the Carbon Stereocenter

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2337
Zhang, Xiao-Yan; An, Yang; Liu, Zhou-Zhou; Fan, Ling-Tao: Claisen-Type Condensation of Ketones with Carboxylic Acids: Synthesis of α,α-Disubstituted β-Keto Carbonyl Compounds

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CIF File
2345
Sommer, Ava G.; Tung, Pinku; Mankad, Neal P.: Alkylation of Arylsulfonyl Cyanides To Form Alkyl Sulfones

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2351
Barabash, Oksana V.; Ostapiuk, Mary Y.; Kravets, Mykola; Obushak, Mykola D.; Schmidt, Andreas; Ostapiuk, Yurii V.: Pyrazol-3-yldiazonium Salts as Key Reagents for C–C Bond Formation and Pyrazole-Containing Heterocycle Synthesis

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2363
Chaise, Samantha; Gacogne, Audrey; Garcin, Ilan; de Figueiredo, Renata Marcia; Campagne, Jean-Marc; Legrand, Baptiste; Maillard, Ludovic T.: Expanding the Scope of Azole-Based γ-Amino Acids – Synthesis and Structural Diversity

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2373
Annapurna, Sasikala Cheemalapati Venkata; Rao, Srinivas Talasila; Bathini, Pavan Kumar; Gaddameedhi, Prashanth Reddy; Komati, Shravan Kumar; Manda, Amarendhar; Nahide, Pradip D.; Reddy, B Ramalinga; Madhra, Mukesh Kumar; Annapragada, Ratnamala; Bandichhor, Rakeshwar: Quality by Design Driven Improved Process of Abiraterone Acetate

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2391
Novák, Tamás T.; Turczel, Gábor; Hornyánszky, Gábor; Szabó, Pál T.; Kiss, Loránd; Fustero, Santos; Nonn, Melinda: Fluorinative Difunctionalization of a Cyclooctene-Fused β-Lactam and Cyclooctene-Fused β-Amino Esters

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