DOI: 10.1055/s-00000084

Synthesis

Issue 04 · Volume 56 · February 2024 DOI: 10.1055/s-014-58998

editorial

table of contents

special topic

Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients (APIs)

549
Chaskar, Sudhir P.; Honparkhe, Ramchandra; Aghao, Arvind K.; Thorat, Rakesh G.; Pramanik, Chinmoy: An Alternative Formal Synthesis of (S)-(+)-Vigabatrin
https://www.thieme-connect.de/media/synthesis/202404/i_c0128_ga_10-1055_s-0042-1751470.gif
561
Varga, Petra Regina; Belovics, Alexandra; Karaghiosoff, Konstantin; Szabó, Rita; Bősze, Szilvia; Drahos, László; Keglevich, György: Efficient Synthesis of Diethyl, Dialkyl α-Hydroxy-propylenebisphosphonates and Related 5-Phosphonoyl-1,2-oxaphospholane 2-Oxides
https://www.thieme-connect.de/media/synthesis/202404/i_c0184_ga_10-1055_a-2122-4178.gif
577
Tintori, Guillaume; Jacob, Clément; Delsarte, Christine; Potié, François; Grimaud, Laurence; Vitale, Maxime; Echeverria, Pierre-Georges: Efficient and Scalable Synthesis of 6,6-Dimethyl-3-oxabicyclo [3.1.0]hexan-2-one through Organocatalyzed Desymmetrization and Chemoselective Reduction
https://www.thieme-connect.de/media/synthesis/202404/i_j0435_ga_10-1055_a-2217-0996.gif
585
Bera, Shyamal Kanti; Bhanja, Rosalin; Sahu, Chandan Chittapriya; Mal, Prasenjit: An Intramolecular Radical C–N Coupling by N-Iodosuccinimide
https://www.thieme-connect.de/media/synthesis/202404/i_m0068_ga_10-1055_a-2063-0221.gif
597
Nakahara, Yuichi; Endo, Yuta; Takahashi, Kazutoshi; Kawaguchi, Tomoko; Kato, Keisuke; Matsuda, Yutaka; Nagaki, Aiichiro: A Manufacturing Strategy Utilizing a Continuous-Mode Reactor toward Homogeneous PEGylated Bioconjugate Production
https://www.thieme-connect.de/media/synthesis/202404/i_m0093_ga_10-1055_a-2077-6187.gif
603
Ramu, Chennam; Kumaraguru, T.; Reddy, M. Sridhar; Rode, Haridas B.; Ghosh, Subhash; Reddy, Ch. Raji; Sudhakar, Gangarajula: Synthesis of Ledipasvir through a Late-Stage Cyclopropanation and Fluorination Process
https://www.thieme-connect.de/media/synthesis/202404/i_m0494_ga_10-1055_s-0042-1751437.gif
611
Sunny, Steeva; Maingle, Mohit; Sheeba, Loddipalle; Pathan, Firojkhan Rajekhan; J., Gowri Sankar; Juloori, Harika; Gadewar, Sainath Ganesh; Seth, Kapileswar: Pd-Nanoparticles-Catalyzed C(sp2)–H Arylation for the Synthesis of Functionalized Heterocycles: Recent Progress and Prospects
https://www.thieme-connect.de/media/synthesis/202404/i_r0041_ga_10-1055_a-2060-3488.gif
639
Zhang, Fei; Zhou, Yong; Wang, Shuangqiang; Zhao, Yao; Wu, Xiaojin; Chen, Rizhi: Palladium-Loading Ceramic Catalytic Membrane Reactors for Mizoroki–Heck Reaction
https://www.thieme-connect.de/media/synthesis/202404/i_b0222_ga_10-1055_a-2119-5236.gif
657
Mahajan, Bhushan; Aand, Dnyaneshwar; Purwa, Mandeep; Mujawar, Taufiqueahmed; Ghosh, Subhash; Pabbaraja, Srihari; Singh, Ajay K.: Elements-Continuous-Flow Platform for Coupling Reactions and Anti-viral Daclatasvir API Synthesis
https://www.thieme-connect.de/media/synthesis/202404/i_c0518_ga_10-1055_a-2022-2063.gif
686
Algera, Russell F.; Davidson, Andrew; Herbert, David K.; Lian, Yajing; Liu, Fangfang; Liu, Yiyang; Nematalla, Asaad; Piper, Jared L.; Magano, Javier; Monfette, Sebastien; Nguyen, Bao; Raggon, Jeffrey W.; Rainville, Joseph P.; Rane, Anil; Tao, Yong; Wang, Ke; Yayla, Hatice G.: Exploratory Process Development of a Pulmonary Arterial Hypertension Clinical Compound via a Late-Stage Pd-Catalyzed Buchwald–Hartwig C–N Coupling
https://www.thieme-connect.de/media/synthesis/202404/i_m0254_ga_10-1055_s-0040-1720087.gif

errata

700
Koswatta, Panduka B.; Sivappa, Rasapalli; Rasika Dias, H. V.; Lovely, Carl J.: Erratum - Total Synthesis of the Leucetta-Derived Alkaloid Calcaridine A