DOI: 10.1055/s-00000084

Synthesis

Issue 04 · Volume 56 · February 2024 DOI: 10.1055/s-014-58998

editorial

  • III
    Laha, Joydev K.; Zhou, Jianrong Steve:

    Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients (APIs)

    • table of contents

  • VII

    Linked PDF of Table of Contents

    • special topic

    Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients (APIs)

  • 527
    Qin, Yang; Liu, Sheng; Shi, Shi-Liang:

    Transition-Metal-Free Cross-Coupling of Acetals and Grignard Reagents To Form Diarylmethyl Alkyl Ethers and Triarylmethanes

    Image for article: Transition-Metal-Free Cross-Coupling of Acetals and Grignard Reagents To Form Diarylmethyl Alkyl Ethers and Triarylmethanes
    Supporting Information (PDF)
  • 539
    Khan, Farooq-Ahmad; Yaqoob, Sana; Qasim, Muhammad Wasim; Ali, Shujaat; Wang, Yan; Jiang, Zi-Hua:

    A Robust, Gram-Scale and High-Yield Synthesis of MDP Congeners for Activation of the NOD2 Receptor and Vaccine Adjuvantation

    Image for article: A Robust, Gram-Scale and High-Yield Synthesis of MDP Congeners for Activation of the NOD2 Receptor and Vaccine Adjuvantation
    Supporting Information (PDF)
  • 549
    Chaskar, Sudhir P.; Honparkhe, Ramchandra; Aghao, Arvind K.; Thorat, Rakesh G.; Pramanik, Chinmoy:

    An Alternative Formal Synthesis of (S)-(+)-Vigabatrin

    Image for article: An Alternative Formal Synthesis of (<i>S</i>)-(+)-Vigabatrin
    Supporting Information (PDF)
  • 553
    Chen, Yang; Li, Qiao-Yue; Xie, Xiao-Yan; Wang, Wei; Li, Dashan; Wang, Wen-Jing; Shao, Li-Dong:

    Construction of an Epoxy-lactone Moiety on the C/D Ring of Highly Oxygenated Triterpenes through a Modified SeO2-Promoted Oxidative Cyclization

    Image for article: Construction of an Epoxy-lactone Moiety on the C/D Ring of Highly Oxygenated Triterpenes through a Modified SeO<sub>2</sub>-Promoted Oxidative Cyclization
    Supporting Information (PDF)
  • 561
    Varga, Petra Regina; Belovics, Alexandra; Karaghiosoff, Konstantin; Szabó, Rita; Bősze, Szilvia; Drahos, László; Keglevich, György:

    Efficient Synthesis of Diethyl, Dialkyl α-Hydroxy-propylenebisphosphonates and Related 5-Phosphonoyl-1,2-oxaphospholane 2-Oxides

    Image for article: Efficient Synthesis of Diethyl, Dialkyl α-Hydroxy-propylenebisphosphonates and Related 5-Phosphonoyl-1,2-oxaphospholane 2-Oxides
    Supporting Information (PDF)
  • 567
    Cui, Hai-Bo; Ma, Ting; Zhang, Ru-Yue; Shan, Jing; Wang, Zhong-Qiang; Bai, Mei; Chen, Yong-Zheng:

    Biocatalytic Synthesis of Chiral Benzylic Alcohols via Enantioselective Hydroxylation by a Self-Sufficient Cytochrome P450 from Deinococcus gobiensis

    Image for article: Biocatalytic Synthesis of Chiral Benzylic Alcohols <i>via</i> Enantioselective Hydroxylation by a Self-Sufficient Cytochrome P450 from <i>Deinococcus gobiensis</i>
    Supporting Information (PDF)
  • 573
    Kumar, Kankanala Naveen; Mhate, Mouzma; Ravichandiran, Velayutham; Swain, Sharada Prasanna:

    Bis(pinacoloto)diboron/4-Phenylpyridine System for One-Pot Photocatalyzed Borylation and Reduction of Aldehyde: Synthesis of Tavaborole in a Flow Reactor

    Image for article: Bis(pinacoloto)diboron/4-Phenylpyridine System for One-Pot Photocatalyzed Borylation and Reduction of Aldehyde: Synthesis of Tavaborole in a Flow Reactor
    Supporting Information (PDF)
  • 577
    Tintori, Guillaume; Jacob, Clément; Delsarte, Christine; Potié, François; Grimaud, Laurence; Vitale, Maxime; Echeverria, Pierre-Georges:

    Efficient and Scalable Synthesis of 6,6-Dimethyl-3-oxabicyclo [3.1.0]hexan-2-one through Organocatalyzed Desymmetrization and Chemoselective Reduction

    Image for article: Efficient and Scalable Synthesis of 6,6-Dimethyl-3-oxabicyclo [3.1.0]hexan-2-one through Organocatalyzed Desymmetrization and Chemoselective Reduction
    Supporting Information (PDF)
  • 585
    Bera, Shyamal Kanti; Bhanja, Rosalin; Sahu, Chandan Chittapriya; Mal, Prasenjit:

    An Intramolecular Radical C–N Coupling by N-Iodosuccinimide

    Image for article: An Intramolecular Radical C–N Coupling by <i>N</i>-Iodosuccinimide
    Supporting Information (PDF)
  • 597
    Nakahara, Yuichi; Endo, Yuta; Takahashi, Kazutoshi; Kawaguchi, Tomoko; Kato, Keisuke; Matsuda, Yutaka; Nagaki, Aiichiro:

    A Manufacturing Strategy Utilizing a Continuous-Mode Reactor toward Homogeneous PEGylated Bioconjugate Production

    Image for article: A Manufacturing Strategy Utilizing a Continuous-Mode Reactor toward Homogeneous PEGylated Bioconjugate Production
    Supporting Information (PDF)
  • 603
    Ramu, Chennam; Kumaraguru, T.; Reddy, M. Sridhar; Rode, Haridas B.; Ghosh, Subhash; Reddy, Ch. Raji; Sudhakar, Gangarajula:

    Synthesis of Ledipasvir through a Late-Stage Cyclopropanation and Fluorination Process

    Image for article: Synthesis of Ledipasvir through a Late-Stage Cyclopropanation and Fluorination Process
    Supporting Information (PDF)
  • 611
    Sunny, Steeva; Maingle, Mohit; Sheeba, Loddipalle; Pathan, Firojkhan Rajekhan; J., Gowri Sankar; Juloori, Harika; Gadewar, Sainath Ganesh; Seth, Kapileswar:

    Pd-Nanoparticles-Catalyzed C(sp2)–H Arylation for the Synthesis of Functionalized Heterocycles: Recent Progress and Prospects

    Image for article: Pd-Nanoparticles-Catalyzed C(sp<sup>2</sup>)–H Arylation for the Synthesis of Functionalized Heterocycles: Recent Progress and Prospects
  • 639
    Zhang, Fei; Zhou, Yong; Wang, Shuangqiang; Zhao, Yao; Wu, Xiaojin; Chen, Rizhi:

    Palladium-Loading Ceramic Catalytic Membrane Reactors for Mizoroki–Heck Reaction

    Image for article: Palladium-Loading Ceramic Catalytic Membrane Reactors for Mizoroki–Heck Reaction
    Supporting Information (PDF)
  • 650
    Ohashi, Eisaku; Sahara, Naoto; Hirano, Yoichi; Hosoya, Masahiro; Takahashi, Yusaku; Tsuno, Naoki:

    An Effective Additive for Introducing the Triazole Unit of Ensitrelvir: Combination of LiCl and Et3N to Easily Generate Lithium Triazinolate

    Image for article: An Effective Additive for Introducing the Triazole Unit of Ensitrelvir: Combination of LiCl and Et<sub>3</sub>N to Easily Generate Lithium Triazinolate
    Supporting Information (PDF)
  • 657
    Mahajan, Bhushan; Aand, Dnyaneshwar; Purwa, Mandeep; Mujawar, Taufiqueahmed; Ghosh, Subhash; Pabbaraja, Srihari; Singh, Ajay K.:

    Elements-Continuous-Flow Platform for Coupling Reactions and Anti-viral Daclatasvir API Synthesis

    Image for article: Elements-Continuous-Flow Platform for Coupling Reactions and Anti-viral Daclatasvir API Synthesis
    Supporting Information (PDF)
  • 668
    Adaoudi, Omaïma; Le Bescont, Julie; Bruneau-Voisine, Antoine; Evano, Gwilherm:

    Copper-Catalyzed Carbonylative Cross-Coupling of Alkyl Iodides with Alcohols and Sodium Hydroxide: Synthesis of Esters and Carboxylic Acids

    Image for article: Copper-Catalyzed Carbonylative Cross-Coupling of Alkyl Iodides with Alcohols and Sodium Hydroxide: Synthesis of Esters and Carboxylic Acids
    Supporting Information (PDF)
  • 677
    Dash, Rupashri; Hota, Sudhir Kumar; Murarka, Sandip:

    Base-Promoted 1,6-Aza-Michael Addition of Azauracils to para-Quinone Methides

    Image for article: Base-Promoted 1,6-Aza-Michael Addition of Azauracils to <i>para</i>-Quinone Methides
    Supporting Information (PDF)
  • 686
    Algera, Russell F.; Davidson, Andrew; Herbert, David K.; Lian, Yajing; Liu, Fangfang; Liu, Yiyang; Nematalla, Asaad; Piper, Jared L.; Magano, Javier; Monfette, Sebastien; Nguyen, Bao; Raggon, Jeffrey W.; Rainville, Joseph P.; Rane, Anil; Tao, Yong; Wang, Ke; Yayla, Hatice G.:

    Exploratory Process Development of a Pulmonary Arterial Hypertension Clinical Compound via a Late-Stage Pd-Catalyzed Buchwald–Hartwig C–N Coupling

    Image for article: Exploratory Process Development of a Pulmonary Arterial Hypertension Clinical Compound via a Late-Stage Pd-Catalyzed Buchwald–Hartwig C–N Coupling
    Supporting Information (PDF)
  • 693
    Das, Soumyadip; Chanda, Kaushik:

    One-Pot Telescopic Approach to Synthesize Disubstituted Benz­imidazoles in Deep Eutectic Solvent

    Image for article: One-Pot Telescopic Approach to Synthesize Disubstituted Benz­imidazoles in Deep Eutectic Solvent
    Supporting Information (PDF)

    • errata

  • 700
    Koswatta, Panduka B.; Sivappa, Rasapalli; Rasika Dias, H. V.; Lovely, Carl J.:

    Erratum - Total Synthesis of the Leucetta-Derived Alkaloid Calcaridine A