Synthesis 2024; 56(04): 657-667
DOI: 10.1055/a-2022-2063
special topic
Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients (APIs)

Elements-Continuous-Flow Platform for Coupling Reactions and Anti-viral Daclatasvir API Synthesis

Authors

  • Bhushan Mahajan

    a   Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
    b   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
  • Dnyaneshwar Aand

    a   Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
    b   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
  • Mandeep Purwa

    a   Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
    b   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
  • Taufiqueahmed Mujawar

    a   Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
  • Subhash Ghosh

    a   Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
    b   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
  • Srihari Pabbaraja

    a   Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
    b   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
  • Ajay K. Singh

    a   Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
    b   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

A.K.S. thanks the Department of Science and Technology (DST), Ministry of Science and Technology, New Delhi, India for financial assistance (DST/INSPIRE/04/2016/000247).


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Abstract

A novel nanotextured Ni@Cu material embedded electro-microflow reactor with minimal electrode distance has been employed to synthesize biphenyls via the construction of a new C–C bond. The reported protocol is devoid of noble metals and involves co-reductant/oxidant-free conditions in a fast manner for the synthesis of substituted/unsubstituted biphenyl systems. The electro-reactor volume was optimized for gram-scale biphenyl synthesis and further extended for an integrated total process system reducing the tedious downstream process by selective removal of unwanted chemicals/solvent. The continuous microflow synthesis of daclatasvir has now been accomplished with a good yield.

Supporting Information



Publication History

Received: 07 November 2022

Accepted after revision: 30 January 2023

Accepted Manuscript online:
30 January 2023

Article published online:
07 March 2023

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