Abstract
The development of non-canonical amino acids is pivotal to peptide engineering, enabling
the design of molecules with novel structural features, improved activities, and optimized
metabolic profiles. Among these, heteroaromatic γ-amino acids have attracted significant
attention for their ability to mimic native peptide folds while accessing novel conformational
spaces. In this study, the chemical diversity of heteroaromatic γ-amino acids was
expanded by introducing two new monomers, ATC* and AOC*, designed around a thiazole
and an oxazole scaffold, respectively. These analogues, characterized by their tunable
substitution patterns and precise stereochemical control significantly expand the
well-established ATC family.
Key words
γ-amino acid - heterocycles - azole scaffold - peptide engineering - peptidomimetic
- solid-phase synthesis
