30. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber

Abstracts (HTML) List of Authors

Maasoumy, B

Thrombozytenzahl, Albumin und Bilirubin identifizieren Patienten mit chronischer Hepatitis C Zirrhose mit hohem Risiko für ein Therapieversagen und schwerwiegende Nebenwirkungen während einer Triple-Therapie mit Boceprevir oder Telaprevir
Successful triple therapy of patients with chronic hepatitis C genotype 1 infection leads to significant improvement of non-invasive liver fibrosis tests

Mahli, A

Novel in vitro model for combined effects of irinotecan and free fatty acids on hepatocellular lipid accumulation and inflammation
Protective effects of Iso-Alpha Acids (IAA) on hepatic steatosis, inflammation and fibrosis
Anti-fibrogenic effects of sylimarin vary significantly in human hepatic stellate cells from different donors
CYP2E1 is a central mediator for the synergistic effects of alcohol and free fatty acids on hepatocellular steatosis and inflammation

Mak, TW

NK cell activity promotes liver damage and chronic viral infection
Reactive oxygen species delay control of lymphocytic choriomeningitis virus

Malek, N

Notch signaling is required for cholangiocarcinoma progression and is enhanced by inactivation of p53 in vivo
Negative Selection In Vivo RNAi Screening Identifies a Ribosomal Protein As A New Therapeutic Target In Liver Cancer
Alpha-1-Antitrypsin inhibits acute liver failure in mice
Capsaicin impairs carcinogenesis of human intra- and extrahepatic cholangiocarcinoma cells

Malek, NP

Wirksamkeit und Sicherheit der Triple-Therapie mit Telaprevir bei 102 Patienten mit Hepatitis C, Genotyp 1: SVR 12 Daten
Secondary resistances to measles virus (MeV)-based virotherapy
Different 5-FC prodrug application regimes result in different oncolytic efficiencies
Epidemiologische Entwicklung und Genotypisierung von Patienten mit einer chronischer Hepatitis B in Deutschland: Hinweise für einen Rückgang des Genotyp A zu Gunsten des Genotyp D
Development of shRNA transgenic mice for preclinical studies of the MKK4 regeneration kinase
Verträglichkeit und Wirksamkeit einer Telaprevir Triple-Therapie der Hepatitis C, Genotyp 1 nach Lebertransplantation – SVR 24 Daten

Malik, I

Changes of gene expression of different BMP-proteins in liver in different mouse and rat models of acute phase reaction

Malik, IA

Role of the Hypoxia Inducible Factors HIF-1α and HIF-2α during hepatic repair in a rat model of thioacetamide (TAA)-induced chronic liver damage
Effect of direct single-dose irradiation on fat metabolism in rat liver: FAT/CD36 as the main responsible protein?
Differential localization of transferrin receptors and lipocalin-2 in rat hepatic and extra-hepatic organs during acute phase response

Mallolas, J

Faldaprevir plus pegyliertes Interferon alpha-2a und Ribavirin (PR) bei Patienten mit HIV und Hepatitis C Genotyp (GT)-1 Koinfektion: End of Treatment Response (ETR) – Ergebnisse der Phase III Studie STARTVerso 4

Manero, M

Faldaprevir plus pegyliertes Interferon alpha-2a und Ribavirin (PR) bei Patienten mit HIV und Hepatitis C Genotyp (GT)-1 Koinfektion: End of Treatment Response (ETR) – Ergebnisse der Phase III Studie STARTVerso 4

Mann, A

Bedeutung des Caspase 8-Homologs cFLIP bei der metabolischen Leberschädigung

Manns, M

Der Simplified AIH Score – Kriterium zur Einleitung einer Immunsuppression bei Patienten mit Primär Sklerosierender Cholangitis: Ergebnisse einer deutschen Multicenter Studie
NAFLD staging by an improved ELISA for serum cytokeratin-18 fragments

Manns, MP

Thrombozytenzahl, Albumin und Bilirubin identifizieren Patienten mit chronischer Hepatitis C Zirrhose mit hohem Risiko für ein Therapieversagen und schwerwiegende Nebenwirkungen während einer Triple-Therapie mit Boceprevir oder Telaprevir
The impact of adipokines hormones on HCV life-cycle
Resectable transgenic tumor models in mice for biliary cancers
Quantification of Large, Middle and Small Hepatitis B virus (HBV) surface protein (HBsAg) fractions in patients with Hepatitis Delta
Primary but not secondary biliary acids inhibit hepatitis D virus entry into human hepatoma cells expressing the sodium-taurocholate cotransporting polypeptide
Retargeting of oncolytic adenoviruses by bispecific adapter molecules reduces viral liver load and improves therapy by triggering antigen-specific CD8 T-cell responses
Endogenous oxidized LDL levels predict treatment response in interferon-based therapy of chronic hepatitis C
Development of an orthotopic HCC mouse model for analysis of tumor-specific CD8 T cell responses
Successful triple therapy of patients with chronic hepatitis C genotype 1 infection leads to significant improvement of non-invasive liver fibrosis tests

Mansmann, U

An algorithm that predicts the viability and the yield of isolated human hepatocytes from surgical remnant tissues

Marbach, E

Wnt-signaling gradients and their impact on liver parenchymal heterogeneity – a link to xenobiotic metabolism
TICK-TOCK-HEDGEHOG: Hedgehog signalling controls the liver circadian clock and vice versa

Marin, JJG

Higher frequency of peripheral CD3CXCR3 and CD4CXCR3 positive blood cells in HCV patients in context of bile acid retention

Markova, AA

Thrombozytenzahl, Albumin und Bilirubin identifizieren Patienten mit chronischer Hepatitis C Zirrhose mit hohem Risiko für ein Therapieversagen und schwerwiegende Nebenwirkungen während einer Triple-Therapie mit Boceprevir oder Telaprevir

Marks, K

Faldaprevir plus pegyliertes Interferon alpha-2a und Ribavirin (PR) bei Patienten mit HIV und Hepatitis C Genotyp (GT)-1 Koinfektion: End of Treatment Response (ETR) – Ergebnisse der Phase III Studie STARTVerso 4

Marquardt, JU

Feasibility and benefits of systemic second-line therapy in advanced hepatocellular carcinoma (HCC) – a retrospective analysis
Effective depletion of hepatic cancer stem-like cells by NF-kB mediated inhibiton of histone deacetylases

Martin, B

Restoration of Hepatitis C virus-specific CD8+ T-cell responses in patients undergoing IFN-free antiviral therapy
A protective HLA-B*27 restricted epitope contributes to viral control in chronic HCV infection despite presence of viral escape mutations and is characterized by a unique T cell phenotype

Martin, M

Tumor containment by immune cells and fibrotic capsule improve survival of patients following resection of colorectal liver metastasis

Martin, R

Leberinfitrierende CD4 T Zellen bei der autoimmunen Hepatitis zeigen ein distinktes TH1 Profil

Martius, G

Effect of direct single-dose irradiation on fat metabolism in rat liver: FAT/CD36 as the main responsible protein?

Mathe, Z

Long-term maintenance of human liver tissue by ex-vivo perfusion of liver sections

Matono, T

Signaling pathways involved in carcinogenesis in a double hit mouse model of cholangiopathy and hepatitis B virus

Matz-Soja, M

Wnt-signaling gradients and their impact on liver parenchymal heterogeneity – a link to xenobiotic metabolism
TICK-TOCK-HEDGEHOG: Hedgehog signalling controls the liver circadian clock and vice versa
Der Wnt und Hedgehog Signalweg im Leberparenchym – Ein Einblick in Zonierung und Funktion
Influence of Carbon Chain Length on Formation and Composition of Triglycerides in Free Fatty Acid- induced Steatosis

Mauss, S

Efficacy and safety of Telaprevir in patients with hepatitis C genotype 1 infection: The German Telaprevir early access program

McJunkin, K

Multiplex in vivo RNAi screening instructs combination therapies to increase the therapeutic efficacy of the multikinase inhibitor sorafenib

Mcllwain, DR

Reactive oxygen species delay control of lymphocytic choriomeningitis virus

Mehrabi, A

Deleted in Malignant Brain Tumors 1 (DMBT1) is differentially expressed in cholangiocarcinogenesis and shows influence on patient survival

Meindl-Beinker, N

Screening for TGFB Signaling Regulator expression in human HCC

Melter, M

Reduktion von Lipo-apoptose in Abhängigkeit der Lokalisation und Isoform des hepatoprotektiven Protein ALR
Palmitinsäure induzierter lipoxischer ER-Stress und Lipo-apoptose wird durch das hepatoprotektive Protein ALR vermindert
Ischämie-Reperfusions vermittelter Schaden wird durch das Leberregenerations assoziiertes Protein ALR vermittelt

Meltzer, P

Tumor suppressive mechanisms in hepatocellular carcinoma through inhibition of IL-6 signaling

Menzel, N

The impact of adipokines hormones on HCV life-cycle

Meurer, S

Hepatic stellate cell specific endoglin deletion modulates TGF-β signaling and aggravates liver fibrosis in two experimental models of murine liver injury

Meurer, SK

Impact of soluble Endoglin on TGF-β1 mediated immediate early responses in HepG2 cells
Antifibrotic effects of CCN1/CYR61 in primary portal myofibroblasts through induction of reactive oxygen species and resulting apoptosis
Differential regulation of Id1 expression by TGF-β1 in HepG2 cells

Meyer, C

Immunotherapeutic retargeting of effector cells towards HBV infected target cells using bispecific antibody constructs

Michael, MP

Alpha-1-Antitrypsin inhibits acute liver failure in mice

Michl, P

Additive anti-Tumor Response to the Rabbit VX2 Hepatoma by Combined Radio Frequency Ablation and Toll like Receptor 9 Stimulation

Michler, T

Correlation of fulminant hepatitis B and escape mutations in the 2nd loop of the HBsAg a-determinant

Milera, H

Verlaufskontrolle des Fibrosegrades nach Lebertransplantation – Histologie und Transiente Elastografie mittels FibroScan im direkten Vergleich

Milkiewicz, M

Individuals with the PNPLA3 (adiponutrin) variant present with unexpected body fat composition: a study in one thousand healthy blood donors

Milkiewicz, P

Individuals with the PNPLA3 (adiponutrin) variant present with unexpected body fat composition: a study in one thousand healthy blood donors

Mittler, J

Programmed liver biopsies after orthotopic liver transplantation predict non-alcoholic steatohepatitis during a 5-year follow up

Mix, C

Thrombozytenzahl, Albumin und Bilirubin identifizieren Patienten mit chronischer Hepatitis C Zirrhose mit hohem Risiko für ein Therapieversagen und schwerwiegende Nebenwirkungen während einer Triple-Therapie mit Boceprevir oder Telaprevir

Mo, FR

Hsp72 overexpression protects from acetaminophen and DDC-associated liver injury but enhances protein aggregation

Moench, C

Gibt es prädiktive Parameter für das frühe HCC-Rezidiv nach Lebertransplantation?

Mohs, A

Die CREMα-abhängige T-Zellantwort hemmt Progression der chronischen Lebererkrankung und deren Komplikationen

Moldenhauer, G

Immunotherapeutic retargeting of effector cells towards HBV infected target cells using bispecific antibody constructs

Mollenhauer, J

Deleted in Malignant Brain Tumors 1 (DMBT1) is differentially expressed in cholangiocarcinogenesis and shows influence on patient survival

Momburg, F

Immunotherapeutic retargeting of effector cells towards HBV infected target cells using bispecific antibody constructs

Monga, SPS

Synergistische Effekte von Beta-Catenin und YAP führen zur Entstehung von Hepatoblastomen in Mäusen und beim Menschen

Moriconi, F

Role of the Hypoxia Inducible Factors HIF-1α and HIF-2α during hepatic repair in a rat model of thioacetamide (TAA)-induced chronic liver damage
Differential localization of transferrin receptors and lipocalin-2 in rat hepatic and extra-hepatic organs during acute phase response
Changes of gene expression of different BMP-proteins in liver in different mouse and rat models of acute phase reaction

Moro, N

Caspase-8 acts as a tumor suppressor in chemically induced hepatocarcinogenesis in mice

Morten, CH

Fxr-independent expression of the oncofetal marker Neighbor of Punc E11 after bile duct ligation in the adult mouse liver

Moss, PA

Virus Infection Of Hepatic Sinusoidal Endothelial Cells Regulates Hepatic T Cell Recruitment And Activation

Muller, M

Synergism between Jnk1 and Jnk2 is a sine qua non condition for hepatic protection against toxicity
Hematopoietic cells-derived Jnk1 drives hepatic injury and hepatocellular carcinoma in IKKγ/NEMO-deleted livers

Müller, E

Programmed liver biopsies after orthotopic liver transplantation predict non-alcoholic steatohepatitis during a 5-year follow up

Müller, M

Expression and function of methylthioadenosine phosphorylase (MTAP) in activated hepatic stellate
Novel in vitro model for combined effects of irinotecan and free fatty acids on hepatocellular lipid accumulation and inflammation
Protective effects of Iso-Alpha Acids (IAA) on hepatic steatosis, inflammation and fibrosis
CYP2E1 is a central mediator for the synergistic effects of alcohol and free fatty acids on hepatocellular steatosis and inflammation
Hepatic steatosis enhances growth and invasiveness of hepatocellular carcinoma
Expression and function of glucose transporter 1 (GLUT1) expression in activated hepatic stellate cells

Müller-Schilling, M

Anti-fibrogenic effects of sylimarin vary significantly in human hepatic stellate cells from different donors
To biopsy or not to biopsy: Evaluation of a large German cohort of patients with unclear hepatopathy and negative for viral hepatitis A, B, or C

Müller-Vieira, U

Comparison of the response of primary rat and human hepatocytes to ethanol exposition in a miniaturized three-dimensional (3D) multi-compartment bioreactor system

Müllhaupt, B

Comparison of transient elastography, 13C-Methacetin meta-bolism, and liver biopsy for evaluation of fibrosis in chronic hepatitis C infection
MicroRNAs as Mediators in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Steatohepatitis
Higher frequency of peripheral CD3CXCR3 and CD4CXCR3 positive blood cells in HCV patients in context of bile acid retention
Computer assisted image analysis of hepatic collagen: ASSO-ciations to metavir staging, transient elastography and 13C methacetin metabolism in patients with chronic hepatitis C infection
Beneficial effects on weight gain, hepatic steatosis and expression of lipogenic target genes in a murine obesity model after IL-1 type cytokine inactivation

Munker, S

Decreased phosphorylated Smad3 at linker site predicts poor prognosis of patients with cholangiocarcinoma