DOI: 10.1055/s-00000083

Synlett

Issue 16 · Volume 36 · October 2025 DOI: 10.1055/s-015-62247

Editorial

  • III
  • table of contents

  • VIII
  • account

    Small Molecules in Medicinal Chemistry

  • 2381
  • 2393
    Sharma, Anu; Vadodariya, Palak K.; Vaddoriya, Vaidehi N.; Dhameliya, Tejas M.:

    Comprehensive Updates on Antitubercular Endeavors Identified in 2023

    Image for article: Comprehensive Updates on Antitubercular Endeavors Identified in 2023
  • 2411
  • 2437
    Thaker, Aanal; Patel, Shrusti; Dey, Rajdeep; Shaw, Suman; Bhatt, Hardik; Patel, Bhumika; Chaube, Udit:

    Advancements in mTOR Inhibitors for Non-Small-Cell Lung Cancer: Mechanisms, Efficacy, and Future Perspectives

    Image for article: Advancements in mTOR Inhibitors for Non-Small-Cell Lung Cancer: Mechanisms, Efficacy, and Future Perspectives
  • 2453
  • 2473
  • perspectives

    Small Molecules in Medicinal Chemistry

  • 2499
    Sanjaykumar, Randhe Siddhant; Basavaraj, Chavan Sagar; Arshad, Anam Sania Md.; Singh, Rohit; Mahindroo, Neeraj:

    A Decade of FDA-Approved Pharmacophore-Based Small Molecules: Advances in Medicinal Chemistry from 2014 to 2024

    Image for article: A Decade of FDA-Approved Pharmacophore-Based Small Molecules: Advances in Medicinal Chemistry from 2014 to 2024
  • 2527
    Goel, Kapil Kumar; Singhal, Peeush; Sathish, Elagandhula; Babu, M. Arockia; Pandey, Sarvesh Kumar; Tyagi, Yogita; Kumar, Roshan; Singh, Thakur Gurjeet; Puri, Sarthak:

    A Minireview on the Morpholine-Ring-Containing U.S. FDA Approved Drugs: A Medicinal-Chemistry-Based Analysis from 2013 to 2023

    Image for article: A Minireview on the Morpholine-Ring-Containing U.S. FDA Approved Drugs: A Medicinal-Chemistry-Based Analysis from 2013 to 2023
  • 2537
    Chandra, Devesh; Sachin, Sachin; Rav, Shourabh; Sharma, Upendra:

    Quinoline-Based FDA-Approved Drugs: Synthetic Route and Clinical Uses

    Image for article: Quinoline-Based FDA-Approved Drugs: Synthetic Route and 
Clinical Uses
  • letter

    Small Molecules in Medicinal Chemistry

  • 2553
    Garg, Aakriti; Bhattacharya, Bireswar; Samanta, Uttam; Singha, Subhankar; Ghosh, Dipanjan; Bhowmik, Subhendu; Jaisankar, Parasuraman; Gupta, Sreya:

    Phototriggered Migration of Indole-Based Cationic Fluorophore from Mitochondria to Nucleolus in Live Cells

    Image for article: Phototriggered Migration of Indole-Based Cationic Fluorophore from Mitochondria to Nucleolus in Live Cells
  • 2559
    Alaeddini, AmirHossein; Karimian, Somaye; Noori, Milad; Dastyafteh, Navid; Mohammadi-Khanaposhtani, Maryam; Ghomi, Minoo Khalili; Bararjanian, Morteza; Iraji, Aida; Javanshir, Shahrzad; Larijani, Bagher; Ranjbar, Parviz Rashidi; Mahdavi, Mohammad:

    Design, Synthesis, Enzymatic Inhibition, and Antioxidant Activity of New 4-Phenylpiperazin-phenoxy-1,2,3-triazol-acetamide Derivatives as Tyrosinase Inhibitors

    Image for article: Design, Synthesis, Enzymatic Inhibition, and Antioxidant Activity of New 4-Phenylpiperazin-phenoxy-1,2,3-triazol-acetamide Derivatives as Tyrosinase Inhibitors
  • 2565
    Ito, Toshiya; Kinoshita, Kazutomo; Tomizawa, Masaki; Shinohara, Shojiro; Nishii, Hiroki; Tanaka, Hiroshi; Kuramoto, Shino; Oikawa, Nobuhiro:

    Development of a Novel Tropomyosin Receptor Kinase Inhibitor Based on Structure–Activity Relationships: Identification of a Promising Clinical Candidate

    Image for article: Development of a Novel Tropomyosin Receptor Kinase Inhibitor Based on Structure–Activity Relationships: Identification of a Promising Clinical Candidate
  • 2573
  • 2577
    Shaw, Suman K.; Dey, Rajdeep; Yadav, Ruchi; Baldiwala, Aliasgar; Patel, Manan; Patel, Bhumika D.; Bhatt, Hardik G.; Natesan, Gopal; Jha, Abhishek; Chaube, Udit:

    Exploring Tetrahydroquinoline Derivatives: A New Frontier in Cancer Treatment

    Image for article: Exploring Tetrahydroquinoline Derivatives: A New Frontier in Cancer Treatment
  • 2585
    Hamdy, Ahmed K.; Araki, Hiroshi; Tateishi, Hiroshi; Toma, Tsugumasa; Radwan, Mohamed O.; Biswas, Shashwata; Kuwata, Takeo; Matsushita, Shuzo; Fujita, Mikako; Niwa, Shin-ichiro; Otsuka, Masami:

    Synthesis of a 5,6-Dihydropyran-2-one Derivative with Dual Anti-Cell-Migration and Anticancer Activity

    Image for article: Synthesis of a 5,6-Dihydropyran-2-one Derivative with Dual Anti-Cell-Migration and Anticancer Activity
  • 2591
    Roy, Sudipta; Kalita, Gitumoni; Maharana, Satyapriya; Chatterjee, Arunima; Jana, Rathin; Nath, Naba K.; Chatterjee, Paresh Nath:

    A Green Approach to 2-Amino-4H-chromenes by Calcium Lactate Catalyzed, One-Pot, Three-Component Reactions

    Image for article: A Green Approach to 2-Amino-4<i>H</i>-chromenes by Calcium Lactate Catalyzed, One-Pot, Three-Component Reactions
  • 2597
  • 2603
  • 2609
    Das, Debojyoti; Sadhukhan, Juheli; Mandal, Pabitra; Pramanik, Smritimoy; Kabir, Alomgir Shah; Adhikari, Susanta Sekhar:

    Synthesis of Novel Coumarin-Appended Dihydrothiopyrimidinones and Evaluation of Their Binding Interactions with Bovine Serum Albumin

    Image for article: Synthesis of Novel Coumarin-Appended Dihydrothiopyrimidinones and Evaluation of Their Binding Interactions with Bovine Serum Albumin
  • 2615
    Milokhov, Demyd S.; Pomalin, Mykhailo S.; Lutsiuk, Tetiana M.; Hys, Vasyl Y.; Virych, Pavlo A.; Poliudov, Anton O.; Popova, Maria V.; Shishkina, Svitlana V.; Volovenko, Yulian M.; Dobrydnev, Alexey V.:

    Benzo[d][1,2]thiazepin-5-one 3-Oxides: An Unexplored Scaffold with Anticancer Activity

    Image for article: Benzo[<i>d</i>][1,2]thiazepin-5-one 3-Oxides: An Unexplored Scaffold with Anticancer Activity
  • 2623
  • 2631
    Khanka, Sonu; Rawat, Kundan S.; Pandey, Priyanka; Pal, Shyamal; Vats, Ravi P.; Rathur, Rajat; Sharma, Kriti; Dipali, Divya; Singh, Divya; Goel, Atul:

    An Efficient Synthesis of 3-Aryl-2H-chromene Derivatives as Potential Bone Anabolic Agents

    Image for article: An Efficient Synthesis of 3-Aryl-2<i>H</i>-chromene Derivatives as Potential Bone Anabolic Agents
  • 2637
  • 2643
  • 2647
  • 2651
  • 2655
    Toledano-Pinedo, Mireia; Diez-Iriepa, Daniel; Porro-Pérez, Alicia; Schäker-Hübner, Linda; Hanl, Maria; Samadi, Abdelouahid; Almendros, Pedro; Iriepa, Isabel; Rodríguez-Fernández, M. Mercedes; Griñán-Ferré, Christian; Siwek, Agata; Wolak, Małgorzata; Satała, Grzegorz; Bojarski, Andrzej J.; Doroż-Płonka, Agata; Handzlik, Jadwiga; Godyń, Justyna; Knez, Damijan; Gobec, Stanislav; Więckowska, Anna; Hansen, Finn K.; Marco-Contelles, José:

    Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative

    Image for article: Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative
  • 2661
    Candito, David A.; Simov, Vladimir; Liu, Ping; Ardolino, Michael J.; Martinot, Theodore; Lyons, Thomas; Qi, Ji; Yin, Jingjun; Hao, Jinglai; Hu, Bin; Chen, Meng; Zhang, Jun; Lam, Yu-hong; Fuller, Peter H.; Ellis, J. Michael; Maddess, Matthew:

    A Concise Synthesis of a Key Azabicyclo[2.1.1]hexane Building Block for N-Heteroaryl Indazole LRRK2 Kinase Inhibitors

    Image for article: A Concise Synthesis of a Key Azabicyclo[2.1.1]hexane Building Block for <i>N</i>-Heteroaryl Indazole LRRK2 Kinase Inhibitors
  • 2666
    Beveridge, Julia; Söderström, Marcus; Balestri, Lorenzo Jacopo Ilic; Prieto-Díaz, Rubén; Gutierrez-de-Teran, Hugo; Odell, Luke R; Hallberg, Mathias; Larhed, Mats; Gising, Johan:

    Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations

    Image for article: Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations
  • errata

  • e3
    Hamdy, Ahmed K.; Araki, Hiroshi; Tateishi, Hiroshi; Toma, Tsugumasa; Radwan, Mohamed O.; Biswas, Shashwata; Kuwata, Takeo; Matsushita, Shuzo; Fujita, Mikako; Niwa, Shin-ichiro; Otsuka, Masami:

    Erratum: Synthesis of a 5,6-Dihydropyran-2-one Derivative with Dual Anti-Cell-Migration and Anticancer Activity