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Synlett
DOI: 10.1055/s-0043-1775478
DOI: 10.1055/s-0043-1775478
letter
Small Molecules in Medicinal Chemistry
Reactive Probe for Fluorescent Detection of Norepinephrine Based On an Excited-State Intramolecular Proton Transfer (ESIPT) Mechanism
D.M. gratefully acknowledges the Director of the Council of Scientific and Industrial Research - Indian Institute of Chemical Technology (CSIR-IICT), India (MLP0108) and the Science and Engineering Research Board (SERB), India (SRG/2023/001243) for funding. The IICT Communication No. for this manuscript is IICT/Pubs./2025/028.
Abstract
Norepinephrine is a key neurotransmitter that plays a critical role in the sympathetic nervous system. Its misuse and lack of regulation is closely associated with the progression of different central nervous system syndromes and neurodegenerative disorders. Herein, a reactive probe based on an excited-state intramolecular proton transfer (ESIPT) mechanism is reported for the selective fluorescent detection of norepinephrine under physiological conditions and in live cells.
Key words
fluorescent probes - norepinephrine - excited-state intramolecular proton transfer - 2-(2′-hydroxyphenyl)benzothiazole - Live-cell imagingSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1775478.
- Supporting Information
Publication History
Received: 25 January 2025
Accepted after revision: 28 March 2025
Article published online:
14 May 2025
© 2025. Thieme. All rights reserved
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