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Synlett
DOI: 10.1055/a-2564-4559
DOI: 10.1055/a-2564-4559
perspectives
Small Molecules in Medicinal Chemistry
Quinoline-Based FDA-Approved Drugs: Synthetic Route and Clinical Uses
This work is funded by the Council of Scientific and Industrial Research, India (CSIR, FTT020503 and MMP035201).
Abstract
In the last 25 years, the U.S. Food and Drug Administration (FDA) approved 11 new molecular entities (NMEs) comprising quinoline as core moiety. These drugs are primarily used for the treatment of anemia, malaria, hepatitis, and various types of cancer, i.e., lung, breast, kidney, blood, and thyroid. Based on their approval date, a chronological discussion on these marketed drugs is provided. This Perspective summarizes the industrial synthesis, mechanism of action, and clinical uses of the quinoline-based FDA-approved NMEs of the 21st century.
1 Introduction
2 Quinoline-Based FDA-Approved Drugs
2.1 Mitapivat (2022)
2.2 Tivozanib (2021)
2.3 Capmatinib (2020)
2.4 Tafenoquine (2018)
2.5 Neratinib (2017)
2.6 Lenvatinib (2015)
2.7 Simeprevir (2013)
2.8 Bosutinib (2012)
2.9 Cabozantinib (2012)
2.10 Bedaquiline (2012)
2.11 Pitavastatin (2009)
3 Conclusion
4 Abbreviations
Publication History
Received: 22 January 2025
Accepted after revision: 21 March 2025
Accepted Manuscript online:
21 March 2025
Article published online:
20 May 2025
© 2025. Thieme. All rights reserved
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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