Thieme E-Books & E-Journals - Zeitschrift für Gastroenterologie / Issue

FV5_01

Tschaharganeh, DF; Latzko, P; Malz, M; Dombrowski, F; Evert, M; Chen, X; Brummelkamp, T; Schirmacher, P; Calvisi, DF; Breuhahn, K: The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

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FV5_02

Ribback, S; Calvisi, DF; Heidecke, CD; Birth, M; Dombrowski, F: Klarzellige Herde veränderter Hepatozyten der menschlichen Leber zeigen eine Überexpression der protoonkogenen Signalwege AKT/mTOR und Ras/Raf1 sowie einen lipogenen Phänotyp (analog dem Hyperinsulinämie-induzierten Hepatokarzinogenese-Modell der Ratte und hepatozellulären Karzinomen beim Menschen)

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FV5_03

Flecken, T; Schmidt, N; Hild, S; Drognitz, O; Price, DA; Neumann-Haefelin, C; Spangenberg, HC; Thimme, R: Naturally occurring, tumor-specific CD8+ T cells in patients with hepatocellular carcinoma display a clear immunodominance

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P5_01

Balachandran, M; Bender, M; Pschowski, R; Joschko, N; Lovas, A; Stremmel, W; Müller, M: Identification of miRNA–34a, miRNA–145 and miRNA–149 as TAp73 and DNp73 targets in hepatocellular carcinoma

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P5_02

Becker, K; Urbanik, T; Boger, R; Jäger, D; Schulze-Bergkamen, H: The role of the tumor suppressor CYLD for the proliferation and invasion of hepatocellular carcinoma cells

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P5_03

Berchtold, S; Lampe, J; Weiland, T; Schleicher, S; Handgretinger, R; Kopp, HG; Reiser, J; Stubenrauch, F; Malek, NP; Bitzer, M; Lauer, UM: Armed oncolytic measles vaccine virus–a novel therapeutic agent for virotherapy of sarcomas of gastrointestinal and non-gastrointestinal origin

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P5_04

Bettinger, D; Schultheiß, M; Bürk, J; Panther, E; Knüppel, E; Küper, R; Thimme, R; Blum, HE; Spangenberg, HC: Impact of tumor markers in diagnosis of patients with hepatocellular carcinoma (HCC) and their clinicopathologic correlation: an interim analysis

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P5_05

Bettinger, D; Schultheiß, M; Knüppel, E; Thimme, R; Blum, HE; Spangenberg, HC: Is Sorafenib an acceptable treatment possibility for patients with advanced hepatocellular carcinoma?

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P5_06

Bitzer, M; Horger, M; Ganten, TM; Siveke, J; Woerns, MA; Dollinger, M; Gerken, G; Scheulen, ME; Wege, H; Mais, A; Jankowsky, R; Hauns, B; Hentsch, B; Lauer, UM: Combination Treatment of Sorafenib and Resminostat, a new HDAC Inhibitor, in Patients with Sorafenib-resistant Hepatocellular Carcinoma (HCC) – Results of the Dose-Escalation Phase

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P5_07

Brost, S; Longerich, T; Hinz, U; Koschny, R; Sykora, J; Batke, E; Breuhahn, K; Schemmer, P; Walczak, H; Stremmel, W; Schirmacher, P; Ganten, TM: Expression of TRAIL receptors and cFLIP correlates with grade of malignancy and survival in patients with hepatocellular carcinoma

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P5_08

Calvisi, DF; Ho, C; Wang, C; Mattu, S; Destefanis, G; Delogu, S; Armbruster, J; Chen, X; Dombrowski, F; Evert, M: Die Ko-Aktivierung von AKT and N-Ras in der Mäuseleber führt zu einer raschen Hepatokarzinogenese, vermittelt über mTORC1, FOXM1/SKP2 und c-Myc

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P5_09

Calvisi, DF; Mattu, S; Delogu, S; De Murtas, V; Gasparetti, G; Destefanis, G; Chen, X; Dombrowski, F; Evert, M: HSF1 ist ein Effektor der Onkogene Ras und AKT und trägt zur Entstehung und Progression des Hepatozellulären Karzinoms bei

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P5_10

Curth, HM; Schievenbusch, S; Marquardt, J; Pryymachuk, G; Goeser, T; Nierhoff, D: The protein phosphatase 2A inhibitior I–2PP2A/SET is highly expressed during murine fetal liver development and hepatocarcinogenesis

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P5_11

Damm, G; Hao, L; Ehnert, S; Blankenstein, A; Nüssler, AK; Knobeloch, D; Glanemann, M: Chemotherapeutic use of Resveratrol on liver cancer cell lines cause damage on primary human hepatocytes

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P5_12

Dzieran, J; Fabian, J; Weng, H; Longerich, T; Breuhahn, K; Schirmacher, P; Dooley, S; Meindl-Beinker, NM: Loss of the TGF-β cytostatic response in liver cancer cells correlates with a reduced Smad3 activation

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P5_13

Dzieran, J; Fabian, J; Gu, X; Weiß, T; Gao, C; Dooley, S; Meindl-Beinker, NM: Smad7 expression is upregulated in HCC patients and correlates with Smad2 mediated downstream signaling in HCC cell lines

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P5_14

Ehedego, H; Boekschoten, M; Müller, M; Gassler, N; Liedtke, C; Trautwein, C: Der Verlust von p21 erhöht die Tumorgenese und Sensitivität gegenüber LPS-induzierter Leberschädigung in NemoΔhepa Mäusen

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P5_15

Eichenmüller, M; Regel, I; Liebl, J; Vollmar, A; von Schweinitz, D; Kappler, R: Promotermethylierungen von IGFBP3 und RASSF1 als Marker für gefäßinvasives Wachstum und Metastasierung bei Hepatoblastomen

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P5_16

Elfimova, N; Noetel, A; Kwiecinski, M; Winkel, N; Ommer, KS; Dienes, HP; Odenthal, M: The loss of miR–198 is crucial for development and progression of hepatocellular carcinoma

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P5_17

Ertle, JM; Heider, D; Wichert, M; Küper, R; Schlaak, JF; Gerken, G: Better detection of Hepatocellular Carcinoma by combining Alphafeto-Protein (AFP) and Des-Gamma-Carboxyprothrombin (DCP)

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P5_18

Evert, M; Calvisi, D; Evert, K; De Murtas, V; Gasparetti, G; Mattu, S; Destefanis, G; Thiel, S; Thiele, A; Ribback, S; Dombrowski, F: Die Dysregulation des Zellmetabolismus, hervorgerufen durch AKT, trägt zur Entstehung der Insulin-induzierten Hepatokarzinogenese bei und lässt sich effektiv durch Gabe des dualen PI3K/mTOR Inhibitors NVP-BEZ235 zurückführen

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P5_19

Goeppert, B; Frauenschuh, L; Zucknick, M; Stenzinger, A; Mehrabi, A; Hafezi, M; Warth, A; Thelen, A; Bahra, M; Sinn, B; Seehofer, D; Neuhaus, P; Schirmacher, P; Weichert, W: Type, Density, and Location of Immune Cells within Cholangiocarcinomas Predict Clinical Outcome

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P5_20

Hartmann, D; Begus-Nahrmann, Y; Lechel, A; Eshraghi, P; Hüser, N; Schirmacher, P; Lee, HW; Friess, H; Rudolph, KL: Verstärkung von Tumorentstehung und Progress durch transiente Telomerdysfunktion in Telomerase-profizienten Mäusen

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P5_21

Henrici, A; Montalbano, R; Quint, K; Ocker, M; Di Fazio, P: Panobinostat treatment determines oncogenic miRNAs down-regulation in liver cancer cells

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P5_22

Hohmeyer, A; Dauch, D; Kang, TW; Longerich, T; Schirmacher, P; Manns, M; Zender, L: In vivo RNAi screening to genetically dissect malignant progression from hepatocytes harboring constitutive active AKT–1

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P5_23

Kah, J; Wüstenberg, A; Keller, A; Sirma, H; Tiegs, G; Sass, G; Dandri, M: Selective induction of apoptosis by HMG-CoA-reductase inhibitors in hepatoma cells is dependent on p53 expression

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P5_24

Keitel, V; Reinehr, R; Reich, M; Sommerfeld, A; Cupisti, K; Knoefel, WT; Häussinger, D: TGR5 (Gpbar–1) is expressed in cholangiocarcinomas and confers apopotosis resistance in isolated cholangiocytes

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P5_25

Kemmerling, R; Kiesslich, T; Alinger, B; Dietze, O; Bösmüller, HC; Ocker, M; Wolkersdörfer, G; Berr, F; Neureiter, D: Expression pattern of stem cell markers in a tissue microarray of human biliary tract cancer

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P5_26

Kloos, A; Gürlevik, E; Woller, N; Strüver, N; Manns, M; Gerardy-Schahn, R; Kubicka, S; Kühnel, F: Transductional Targeting of oncolytic adenoviruses by CARex-pSia adapter molecules improves therapy of pSia-expressing tumors and reduces viral liver load

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P5_27

Koch, A; Bosserhoff, A; Hellerbrand, C: GLUT 1 expression favors formation and growth of hepatic metastasis

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P5_28

Koenig, L; Soboletzki, M; Mainhard, M; Stremmel, W; Müller, M: p53, p63, p73 and the mitochondrial apoptosis signaling pathway in human hepatocellular carcinoma (HCC)

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P5_29

Lampe, J; Bossow, S; Smirnow, I; Timo, W; Neubert, W; Malek, NP; Bitzer, M; Lauer, UM: Treatment of hepatocellular carcinoma with a novel suicide gene-expressing oncolytic measles vaccine virus

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P5_30

Lange, S; Lampe, J; Zimmermann, M; Bossow, S; Neubert, W; Malek, NP; Bitzer, M; Lauer, UM: Preclinical evaluation of the oncolytic effect of recombinant, suicide gene-armed measles vaccine virus (MeV)-vectors on cholangiocarcinoma cells

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P5_31

Lü, S; Rizzani, A; Kolligs, FT; Göke, B; Gerbes, A; De Toni, EN: Antitumor efficacy of the c-met inhibitor tivantinib (ARQ–197) in liver cancer cells: effects on apoptosis and cell cycle

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P5_32

Lukowski, S; Weng, H; Gu, X; Li, Q; Gao, C; Dooley, S; Ilkavets, I: TGF-beta induced hepatocellular Wisp1 is expressed in hepatocellular carcinoma and drives proliferation of epithelial-type cancer cells

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P5_33

Maass, T; Marquardt, JU; Westphal, H; Galle, PR; Teufel, A: Molekulare Mechanismen der vermehrten Hepatokarzinogenese nach Dkk2 Deletion

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P5_34

Marquardt, JU; Fischer, K; Teufel, A; Krupp, M; Thorgeirsson, SS; Galle, PR; Strand, S: Loss of SIRT6 in hepatocellular carcinomas: associated molecular traits and clinical implications

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P5_35

Mayer, N; Berchtold, S; Zimmermann, M; Königsrainer, I; Königsrainer, A; Glatzle, J; Fehrenbacher, B; Schaller, M; Malek, NP; Bitzer, M; Lauer, UM: Novel treatment approach for therapy of peritoneal carcinosis using Vaccinia virotherapeutics

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P5_36

Meinhard, M; Koenig, L; Pelc, A; Joschko, N; Schulze-Bergkamen, H; Stremmel, W: Transkriptionelle und Post-Transkriptionelle Regulation von Mcl–1 durch die p53-Familie

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P5_37

Metzger, J; Negm, A; Plentz, R; Wedemeyer, J; Mischak, H; Manns, MP; Lankisch, TO: Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary diseases

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P5_38

Monin, MB; Krause, P; Flikweert, H; Seif, A; Wolfgramm, S; Streich, R; Kendziorra, E; Ghadimi, M; Becker, H; König, S: Niclosamid inhibiert das Wachstum kolorektaler Lebermetastasen durch Reduktion der Wnt-Aktivität

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P5_39

Montalbano, R; Di Fazio, P; Quint, K; Glebe, D; Ocker, M: Induction of endoplasmic reticulum-mediated stress pathways in liver cancer cell lines after overexpression of Hepatitis B virus envelope proteins

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P5_40

Munker, S; Liu, Y; Meyer, C; Dooley, S; Li, J; Weng, H: TGF-β1 contributes to intrahepatic cholangiocarcinoma via Smad dependent and independent pathways

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P5_41

Naz, N; Mailk, IA; Schultz, F; Mansuroglu, T; Ramadori, G: Expression of prospero-related homeobox 1 (prox–1) transcription factor and epithelial adhesion molecule (EpCAM) in a rat model of intrahepatic cholangiocarcinogenesis

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P5_42

Neumann, O; Kesselmeier, M; Radlwimmer, B; Schemmer, P; Lorenzo Bermejo, J; Schirmacher, P; Longerich, T: Methylation profiling combined with genomic and transcriptomic data points out to new tumor suppressor genes in human hepatocarcinogenesis

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P5_43

Noll, M; Berchtold, S; Lampe, J; Malek, NP; Bitzer, M; Lauer, UM: Breaking tumor resistances by broad spectrum assessment of virotherapeutic resistance phenomena

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P5_44

Pellegrino, R; Neumann, O; Schirmacher, P; Longerich, T: AKT signaling is involved in protumorigenic function of MDM4 in human hepatocellular carcinoma

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P5_45

Plentz, R; Vogel, A; Kirchhoff, T; Manns, M; Malek, N: Analysis of elderly patients with hepatocellular carcinoma undergoing transarterial chemoembolization in Germany

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P5_46

Pusterla, T; Németh, J; Stein, I; Wiechert, L; Knigin, D; Marhenke, S; Longerich, T; Vogel, A; Bierhaus, A; Pikarsky, E; Hess, J; Angel, P: RAGE is required for oval cell activation and inflammation-associated mouse liver carcinogenesis

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P5_47

Salnikova, O; Breuhahn, K; Ryschich, E: Influence of IL–1β and IL–1 receptor antagonist on T-cell adhesion to hepatic endothelial cells: a potential implication for leukocyte recruitment in HCC

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P5_48

Saugspier, M; Thasler, WE; Heilmann, J; Hellerbrand, C: Hop bitter acids inhibit PD-L1 expression and tumorigenicity of hepatocellular carcinoma cells

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P5_49

Schattenberg, JM; Nelles, C; Wörns, MA; Koch, S; Galle, PR; Schuchmann, M; Weinmann, A: Hepatozelluläres Karzinom (HCC) bei NASH – Trend zur Metastasierung?

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P5_50

Schmitz, V; Rybicki, A; Sauerbruch, T; Raskopf, E: Die Gabe von Nexavar beeinflusst in hypoxischen Cholangiokarzinomzellen das Zellüberleben

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P5_51

Schrader, J; Gordon-Walker, TT; Fahl, M; Lohse, AW; Iredale, JP: Targeting the cytoskeleton inhibits proliferation of hepatoma cells by suppressing mitogenic signalling

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P5_52

Schulze, K; Beneken, C; Staufer, K; Nashan, B; Lohse, AW; Pantel, K; Riethdorf, S; Wege, H: EpCAM-positive zirkulierende Tumorzellen als möglicher prognostischer Biomarker für ein fortgeschrittenes HCC

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P5_53

Singer, SR; Barsotti, A; Fazollahi, M; Ouwehand, A; Grünwald, D; Breuhahn, K; Bussemaker, H; Singer, R; Schirmacher, P; Prives, C: A nuclear pore component regulates select p53 target genes

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P5_54

Sprinzl, MF; Ackermann, K; Busch, D; Protzer, U; Protzer, U: Klonierung AFP-spezifischer HLA.A2 allo-restringierter cytotoxischer T-Zellen aus dem naiven T Zell Repertoire

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P5_55

Sprinzl, MF; Weinmann, A; Esposito, I; Friess, H; Otto, G; Nüssler, A; Galle, PR; Schuchmann, M; Heikenwälder, M; Protzer, U: Hemmung der Makrophagen abhängigen Wachstumsfaktoren durch Sorafenib

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P5_56

Sunami, Y; Kokai, E; Leithäuser, F; Riedl, P; Brunner, C; Gul, S; Schirmbeck, R; Strnad, P; Wirth, T: IKK/NF-κB system protects from Hepatitis B surface antigen-induced hepatocarcinogenesis

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P5_57

Thomaschewski, M; Weber, K; Cornils, K; Ittrich, H; Wege, H; Fehse, B; Benten, D: Multi-color RGB-Marking: Eine neue Methode zur Analyse des klonalen Ursprungs von Lebertumoren in vivo

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P5_58

Timo, W; Klein, K; Zimmermann, M; speicher, T; Venturelli, S; Berger, A; Bantel, H; Königsrainer, A; Schenk, M; Weiss, TS; Wendel, A; Schwab, M; Malek, NP; Bitzer, M; Lauer, UM: Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates

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P5_59

Trierweiler, C; Willim, K; Blum, HE; Hasselblatt, P: Role of the transcription factor c-Jun/AP–1 in response to β-Catenin signaling in the liver

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P5_60

Valletta, D; Czech, B; Weiss, TS; Bosserhoff, A; Hellerbrand, C: Fat1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis

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P5_61

Weber, SN; Bohner, A; Lammert, F: Komplexe genetische Determinanten der HCC-Initiation

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P5_62

Werner, T; Breitfeld, P; Johanniemann, K; Koops, A; Lohse, AW; Wege, H: Palliative Therapie des HCC mittels transarterieller Chemoembolisation (TACE) außerhalb von Studien: Retrospektive Analyse an einem universitären Zentrum

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P5_63

Zimmer, V; Höblinger, A; Grünhage, F; Sauerbruch, T; Lammert, F: Einfluss der HFE-Varianten C282Y und H63D auf das genetische Risiko bösartiger Gallenwegserkrankungen: potentielle Modulation durch H63D-Homozygotie

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P5_64

Zimmermann, M; Armeanu-Ebinger, S; Bossow, S; Lampe, J; Smirnow, I; Lange, S; Weiss, TS; Neubert, W; Malek, NP; Lauer, UM; Bitzer, M: Novel oncolytic Sendai viruses (SeV) for the virotherapeutic treatment of HCC

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