Zeitschrift für Gastroenterologie

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• 1. Fibrogenese, Mediatoren, Nichtparenchymzellen

FV1_01

Roderfeld, M; Kampschulte, M; Langheinrich, A; Tschuschner, A; Kremer, S; Roeb, E:

Artherosklerosemäuse (apoE-/- x LDLR-/-) entwickeln eine Leberfibrose mit HCC unter fettreicher Diät

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FV1_02

Lange, N; Sieber, S; Erhardt, A; Sass, G; Kreienkamp, HJ; Tiegs, G:

Essential role of Sharpin in TNFα dependent NFκB activation in primary hepatocytes

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FV1_03

Hall, R; Heim, I; Huss, S; Alberts, R; Schughart, K; Hochrath, K; Weber, SN; Müllenbach, R; Williams, RW; Lammert, F:

Identification of phenotypic and expression quantitative trait loci (p/eQTLs) affecting liver fibrosis by genome-wide association analysis in recombinant inbred mouse lines

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P1_01

Arndt, S; Wacker, E; Saugspier, M; Dorn, C; Hellerbrand, C; Bosserhoff, A:

BMP6 protects against hepatic inflammation and fibrosis in experimental NASH models

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P1_02

Barikbin, R; Neureiter, D; Wirth, JW; Erhardt, A; Schwinge, D; Kluwe, J; Schramm, C; Tiegs, G; Sass, G:

Induction of heme oxygenase 1 in Mdr2ko mice reduces hepatic inflammation, prevents fibrosis progression and supports fibrolysis

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P1_03

Borkham-Kamphorst, E; Huss, S; Van de Leur, E; Haas, U; Weiskirchen, R:

Adenoviral expression of the Nephroblastoma overexpressed gene product (CCN3/NOV) induces apoptosis and inhibits epithelial-to-mesenchymal transition (EMT) in hepatocytes in vitro but fails to attenuate ongoing liver fibrogenesis in vivo

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P1_04

Breitkopf-Heinlein, K; Li, Q; Goumans, MJ; Wiercinska, E; ten Dijke, P; Dooley, S:

Neutralization of Bone Morphogenetic Protein (BMP)–9 in mouse liver reduces CCl–4 mediated fibrogenesis

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P1_05

Cubero, FJ; Zhao, G; Hatting, M; Drvarov, O; Nevzorova, Y; Al Massoudi, M; Gassler, N; Liedtke, C; Trautwein, C:

JNK1 is protective for the progression of NEMO-dependent hepatitis

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P1_06

Czech, B; Valletta, D; Saugspier, M; Weiss, TS; Dorn, C; Bosserhoff, A; Hellerbrand, C:

Increased expression of the glucose transporter GLUT1 in liver fibrosis

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P1_07

Czech, B; Valletta, D; Saugspier, M; Dettmer, K; Stevens, A; Dorn, C; Weiss, TS; Bosserhoff, A; Oefner, P; Hellerbrand, C:

Downregulation of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease promotes hepatic inflammation and fibrosis

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P1_08

Dorn, C; Heilmann, J; Hellerbrand, C:

Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis

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P1_09

Dorn, C; Hellerbrand, C:

Xanthohumol improves glucose tolerance and inhibits hepatic steatosis, inflammation and fibrogenesis in a murine model of non-alcoholic steatohepatitis

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P1_10

Dostert, K; Saugspier, M; Dorn, C; Hellerbrand, C; Gäbele, E:

The Role of PI3K p110gamma in chronic liver injury

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P1_11

Dostert, K; Dorn, C; Weiss, TS; Gäbele, E; Hellerbrand, C:

Enhanced TLR4 expression in steatotic hepatocytes

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P1_12

Godoy, P; Schmidt-Heck, W; Widera, A; Campos, G; Guthke, R; Gebhardt, R; Arrese, M; Dooley, S; Reif, R; Hengstler, JG:

Cultivation of primary hepatocytes induces an inflammation-cholestasis response that resembles features of in vivo inflammation during damage and regeneration

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P1_13

Granzow, M; Klein, S; Schierwagen, R; Linhart, M; Werner, N; Huss, S; Sauerbruch, T; Trebicka, J:

Der AT1-Rezeptor reguliert die Expression der Renin-Angiotensin-Systen(RAS)-Komponenten in der Fibrose

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P1_14

Granzow, M; Klein, S; Schierwagen, R; Kahrmann, K; Linhart, M; Huss, S; Werner, N; Sauerbruch, T; Trebicka, J:

Rolle der Janus-Kinase 2 (Jak2) bei der AT1-Rezeptor-vermittelten hepatischen Fibrose

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P1_15

Granzow, M; Klein, S; Granzow, R; Gautsch, S; Himmit, M; Huss, S; Sauerbruch, T; Trebicka, J:

Renin-überexprimierende Ratten, ein genetisches Tiermodell zur spontanen Fibrose und portalen Hypertension

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P1_16

Henkel, J; Schanze, N; Brevick, L; Püschel, GP:

Schlüsselrolle von PGE2 im Circulus vitiosus der Prostaglandin- und Cytokin-vermittelten hepatischen Insulinresistenz

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P1_17

Heymann, F; Hammerich, L; Gassler, N; Luedde, T; Trautwein, C; Tacke, F:

The chemokine receptor CCR8 critically controls hepatic macrophage migration and differentiation in murine liver fibrosis

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P1_18

Hochrath, K; Müller, A; Krawczyk, M; Bücker, A; Lammert, F:

Non-invasive quantification of hepatic fibrosis in the CCl4 mouse model by magnetic resonance relaxometry (MRR): first results

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P1_19

Hua, Q; Glassen, K; Waldherr, R; Millonig, G; Mueller, S; Seitz, HK:

Hepatic cytochrome P–4502E1 induction correlates significantly with the degree of steatosis, inflammation, fibrosis and exocyclic etheno DNA-adducts in patients with alcoholic steatohepatitis (ASH) and non-alcoholic fatty liver disease (NAFLD)

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P1_20

Huang, J; Elfimova, N; Noetel, A; Amer, W; Kwiecinski, M; Dienes, HP; Peter, H; Odenthal, M:

TGF-beta mediates transcriptional repression of miR–29 a/b1 during liver fibrosis

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P1_21

Kaldenbach, M; Liedtke, C; Tschaharganeh, DF; Erschfeld, S; Trautwein, C; Streetz, K:

Die Transplantation Apoptose-resistenter (Caspase8Dhepa) Hepatozyten führt zur erfolgreichen Repopulation und Reduktion der Entzündungsaktivität im NEMO-/- Mausmodell

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P1_22

Klein, S; Granzow, M; Schierwagen, R; Huss, S; Van Beuge, M; Poelstra, K; Sauerbruch, T; Trebicka, J:

HSC gezielte Hemmung der Rho-kinase senkt den Portaldruck mit geringen systemischen Nebenwirkungen

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P1_23

Klein, S; Granzow, M; Schierwagen, R; Lalemann, W; Sauerbruch, T; Trebicka, J:

Jak–2 Hemmung senkt den Pfortaderdruck bei der Leberzirrhose

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P1_24

Klein, S; Granzow, M; Schierwagen, R; Huss, S; Körner, C; Weber, S; Fürst, D; Pieper-Fürst, U; Nattermann, J; Lammert, F; Trebicka, J; Sauerbruch, T:

Atorvastatin vermindert die Proliferation und Apoptose in hepatischen Sternzellen durch die Seneszenz Induktion

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P1_25

Krawczyk, M; Sauerbruch, T; Höblinger, A; Hess, G; Lammert, F; Grünhage, F:

Signature of three novel surrogate markers predicts liver stiffness and fibrosis stages in a cohort of patients with chronic liver disease

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P1_26

Krawczyk, M; Mahler, MG; Lammert, F; Grünhage, F:

Identification of a novel genetic risk factor for liver fibrosis within the adiponutrin (PNPLA3) pathway: elastography-based study in patients with chronic liver diseases

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P1_27

Liu, Y; Meyer, C; Ilkavets, I; Li, Q; Müller, A; Dooley, S; Weng, HL:

Dll4 plays a critical role in HBV-associated liver fibrogenesis

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P1_28

Ludwig, JM; Chamulitrat, W; Stremmel, W; Pathil, A:

Das Gallensäure-Phospholipid-Konjugat Ursodeoxycholyl-Lysophosphatidylethanolamid (UDCA-LPE) vermindert die LPS-vermittelte Inflammation in der Leber

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P1_29

Lunova, M; Vaulont, S; Haybaeck, J; Lackner, K; Strnad, P:

Hepcidin knockout mice as a model of iron-overload associated liver fibrosis development

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P1_30

Mahli, A; Thasler, WE; Weiss, TS; Gäbele, E; Hellerbrand, C:

Novel in vitro models of alcohol-mediated hepatic injury

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P1_31

Marquardt, JU; Maass, T; Krupp, M; Staib, F; Gaiser, T; Andersen, JB; Galle, PR; Thorgeirsson, SS; Teufel, A:

Mechanistic and therapeutic implications of PDGF-b activation during liver fibrogenesis

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P1_32

Meurer, SK; Wimmer, AE; van de Leur, E; Weiskirchen, R:

More than a serum parameter: Functional relevance of soluble endoglin (solEng)

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P1_33

Meyer, C; Liu, Y; Schindler, F; Dzieran, J; Dooley, S:

Extracellular matrix induced signaling and TGF-β regulate Caveolin–1 expression in hepatocytes

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P1_34

Millonig, G; Ottinger, S; Seitz, HK; Mueller, S:

Oxidative stress as antifibrogenic stimulus? Low dose steady state H2O2 induces fibrolytic MMP–3 in vitro and in vivo

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P1_35

Müllenbach, R; Hall, R; Dooley, S; Lammert, F:

Mapping differential susceptibility of primary hepatocytes to TGF-β in the BXD population of recombinant inbred mouse lines

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P1_36

Müller, K; Güldiken, N; Kücükoglu, O; Chen, Y; Usachov, V; Kulaksiz, H; Strnad, P:

TAA aber nicht CCl4 reduziert Hepcidin-Expression und führt zu einer Eisenüberladung in der Leber

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P1_37

Nellen, A; Heinrichs, D; Moreno Zaldivar, M; Fischer, P; Berres, ML; Proudfoot, A; Trautwein, C; Wasmuth, HE:

Inhibiting the oligomerisation and glycosaminoglycan binding of the chemokine CCL5 reduces experimental liver injury in vivo

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P1_38

Nischalke, HD; Berger, C; Luda, C; Coenen, M; Krämer, B; Körner, C; Nattermann, J; Sauerbruch, T; Spengler, U:

Das CXCL1 rs4074 A Allel führt nach TLR2 Stimulation zu einer verstärkten CXCL1 Expression und ist ein Risikofaktor für Zirrhose bei HCV Genotype 1-infizierten Patienten

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P1_39

Noetel, A; Strack, I; Elfimova, N; Kwiecinski, M; Dienes, HP; Odenthal, M:

Sekretionsprofile extrazellulärer miRNA nach myofibroblastischer Transdifferenzierung Hepatischer Sternzellen: Neue Biomarker der Fibrose?

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P1_40

Noetel, A; Altmüller, J; Elfimova, N; Kwiecinski, M; Nürnberg, P; Dienes, HP; Odenthal, M:

Identifizierung von neuen microRNA-Zieldomänen während der myofibroblastischen Transdifferenzierung von hepatischen Sternzellen durch "Next Generation Sequencing"

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P1_41

Pasupuleti, S; Koc, A; Batra, A; Siegmund, B; Kremer, S; Roderfeld, M; Roeb, E:

Transfer colitis in Rag1-/-- mice enhances hepatic MMP–9 expression

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P1_42

Pieper-Fürst, U; Hall, R; Hochrath, K; Tacke, F; Weiskirchen, R; Lammert, F:

Evidence for a heterodimeric structure of megalin in liver macrophages

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P1_43

Pinna, F; Tuncay, S; D'Alessandro, LA; Gauges, R; Bissinger, M; Klingmuller, U; Kummer, U; Schirmacher, P; Breuhahn, K:

Dissection TNFα/NF-κB signalling in murine hepatocytes–a model for the priming phase of liver regeneration

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P1_44

Raskopf, E; Vogt, A; Sauerbruch, T; Schmitz, V:

Toxische Leberschädigung führt im Mausmodell zu einem vermehrten Einwandern von Endothelzellen und endothelialen Vorläuferzellen

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P1_45

Sahin, H; Schmitz, P; Kiessling, F; Trautwein, C; Wasmuth, HE:

The CXCR3 ligand CXCL9 attenuates neoangiogenesis and liver fibrosis in vivo

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P1_46

Saugspier, M; Dorn, C; Hellerbrand, C:

Aging promotes hepatocellular steatosis, inflammation and fibrosis in non-alcoholic steatohepatitis in mice

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P1_47

Schelcher, C; Lee, S; Casey, C; Gashi, S; Jauch, KW; Thasler, WE:

Human augmenter of liver regeneration could have a potential protective role in an alcohol-induced toxicity model

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P1_48

Schildgen, J; Sass, G; Schlueter, H; Tiegs, G:

Nitric oxide supports carbon monoxide-induced protection from apoptosis in isolated primary mouse hepatocytes

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P1_49

Scholten, D; Al-samman, M; Sahin, H; Trautwein, C; Wasmuth, HE:

G-Protein-Rezeptor abhängige Immunmodulation durch Induktion der KC Expression (murines CXCL8/IL–8 Homolog) in murinen hepatischen Sternzellen nach Stimulation mit CXCL9

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P1_50

Stock, MK; Hammerich, L; Berres, ML; Trautwein, C; Tacke, F; Wasmuth, HE:

Antagonism of CCL5 chemokine receptors during regression of liver fibrosis is associated with an intrahepatic shift towards pro-inflammatory macrophages

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P1_51

Valletta, D; Czech, B; Saugspier, M; Dorn, C; Bosserhoff, A; Hellerbrand, C:

Expression of the atypical cadherin Fat1 in hepatic fibrosis

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P1_52

Valletta, D; Czech, B; Weiss, TS; Dorn, C; Hellerbrand, C:

Atrophin 2 expression in chronic liver disease functionally affects activated hepatic stellate cells

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P1_53

Vogt, A; Decker, G; Conchon, S; Sauerbruch, T; Gonzalez-Carmona, M:

Beschleunigtes Tumorwachstum des spontanen Hepatozellulären Karzinoms (HCC) in fibrotischer/zirrhotischer Leber im Mausmodell

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P1_54

Wahl, K; Joka, D; Bahr, MJ; Manns, MP; Bantel, H:

Prospektive Evaluation serologischer Biomarker des Zelltodes für den Fibrosenachweis bei chronischen Lebererkrankungen

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P1_55

Walter, R; Wanninger, J; Bauer, S; Eisinger, K; Schäffler, A; Dorn, C; Weiss, TS; Hellerbrand, C; Buechler, C:

MMP–9 activity is increased by adiponectin in primary human hepatocytes but negatively correlates with serum adiponectin in a rodent model of non-alcoholic steatohepatitis

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P1_56

Wang, B; Bröring, R; Real, CI; Trippler, M; Gerken, G; Lu, M; Schlaak, JF:

HCV/TLR3 modulated the expression of RANTES in murine activated hepatic stellate cells

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P1_57

Weber, SN; Bohner, A; Goebel, R; Adrian, I; Lammert, F; Grünhage, F:

Evidence for differential modulation of liver fibrogenesis by selective inhibition of the chemokine receptor CCR1 in a toxic model but not Abcb4-/- mice

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P1_58

Weiskirchen, R; Weimer, J; Arnold, N; Xu, L; Friedman, SL; Bergmann, C:

Genetic characteristics of the human hepatic stellate cell line LX–2

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P1_59

Weng, H; Radaeva, S; Feng, D; Gao, Y; Liu, Y; Li, Q; Shen, H; Müllenbach, R; Huang, T; Chen, JL; Zimmer, V; Lammert, F; Mertens, PR; Zakhari, S; Cai, WM; Dooley, S; Gao, B:

IFN-gamma inhibits hepatic progenitor cell activation in patients with chronic hepatitis B and in mice

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P1_60

Wirth, JW; Gupta, S; Benten, D; Kluwe, J:

Immortalisierte humane hepatische Sternzellen migrieren schädigungsspezifisch in der Mausleber und führen zu exzessiver Leberfibrose

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P1_61

Wojtalla, A; Singer, MV; Sauerbruch, T; Zimmer, A; Siegmund, SV:

Analysis of cellular origin and degradation pathways of the endocannabinoid 2-arachidonoyl glycerol during liver fibrogenesis

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