Synthesis

Category: Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients (APIs)

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Issue 04/2024

  • Khan, Farooq-Ahmad; Yaqoob, Sana; Qasim, Muhammad Wasim; Ali, Shujaat; Wang, Yan; Jiang, Zi-Hua:

    A Robust, Gram-Scale and High-Yield Synthesis of MDP Congeners for Activation of the NOD2 Receptor and Vaccine Adjuvantation

    Image for article: A Robust, Gram-Scale and High-Yield Synthesis of MDP Congeners for Activation of the NOD2 Receptor and Vaccine Adjuvantation
  • Chaskar, Sudhir P.; Honparkhe, Ramchandra; Aghao, Arvind K.; Thorat, Rakesh G.; Pramanik, Chinmoy:

    An Alternative Formal Synthesis of (S)-(+)-Vigabatrin

    Image for article: An Alternative Formal Synthesis of (<i>S</i>)-(+)-Vigabatrin
  • Varga, Petra Regina; Belovics, Alexandra; Karaghiosoff, Konstantin; Szabó, Rita; Bősze, Szilvia; Drahos, László; Keglevich, György:

    Efficient Synthesis of Diethyl, Dialkyl α-Hydroxy-propylenebisphosphonates and Related 5-Phosphonoyl-1,2-oxaphospholane 2-Oxides

    Image for article: Efficient Synthesis of Diethyl, Dialkyl α-Hydroxy-propylenebisphosphonates and Related 5-Phosphonoyl-1,2-oxaphospholane 2-Oxides
  • Tintori, Guillaume; Jacob, Clément; Delsarte, Christine; Potié, François; Grimaud, Laurence; Vitale, Maxime; Echeverria, Pierre-Georges:

    Efficient and Scalable Synthesis of 6,6-Dimethyl-3-oxabicyclo [3.1.0]hexan-2-one through Organocatalyzed Desymmetrization and Chemoselective Reduction

    Image for article: Efficient and Scalable Synthesis of 6,6-Dimethyl-3-oxabicyclo [3.1.0]hexan-2-one through Organocatalyzed Desymmetrization and Chemoselective Reduction
  • Bera, Shyamal Kanti; Bhanja, Rosalin; Sahu, Chandan Chittapriya; Mal, Prasenjit:

    An Intramolecular Radical C–N Coupling by N-Iodosuccinimide

    Image for article: An Intramolecular Radical C–N Coupling by <i>N</i>-Iodosuccinimide
  • Nakahara, Yuichi; Endo, Yuta; Takahashi, Kazutoshi; Kawaguchi, Tomoko; Kato, Keisuke; Matsuda, Yutaka; Nagaki, Aiichiro:

    A Manufacturing Strategy Utilizing a Continuous-Mode Reactor toward Homogeneous PEGylated Bioconjugate Production

    Image for article: A Manufacturing Strategy Utilizing a Continuous-Mode Reactor toward Homogeneous PEGylated Bioconjugate Production
  • Ramu, Chennam; Kumaraguru, T.; Reddy, M. Sridhar; Rode, Haridas B.; Ghosh, Subhash; Reddy, Ch. Raji; Sudhakar, Gangarajula:

    Synthesis of Ledipasvir through a Late-Stage Cyclopropanation and Fluorination Process

    Image for article: Synthesis of Ledipasvir through a Late-Stage Cyclopropanation and Fluorination Process
  • Sunny, Steeva; Maingle, Mohit; Sheeba, Loddipalle; Pathan, Firojkhan Rajekhan; J., Gowri Sankar; Juloori, Harika; Gadewar, Sainath Ganesh; Seth, Kapileswar:

    Pd-Nanoparticles-Catalyzed C(sp2)–H Arylation for the Synthesis of Functionalized Heterocycles: Recent Progress and Prospects

    Image for article: Pd-Nanoparticles-Catalyzed C(sp<sup>2</sup>)–H Arylation for the Synthesis of Functionalized Heterocycles: Recent Progress and Prospects
  • Zhang, Fei; Zhou, Yong; Wang, Shuangqiang; Zhao, Yao; Wu, Xiaojin; Chen, Rizhi:

    Palladium-Loading Ceramic Catalytic Membrane Reactors for Mizoroki–Heck Reaction

    Image for article: Palladium-Loading Ceramic Catalytic Membrane Reactors for Mizoroki–Heck Reaction
  • Mahajan, Bhushan; Aand, Dnyaneshwar; Purwa, Mandeep; Mujawar, Taufiqueahmed; Ghosh, Subhash; Pabbaraja, Srihari; Singh, Ajay K.:

    Elements-Continuous-Flow Platform for Coupling Reactions and Anti-viral Daclatasvir API Synthesis

    Image for article: Elements-Continuous-Flow Platform for Coupling Reactions and Anti-viral Daclatasvir API Synthesis
  • Algera, Russell F.; Davidson, Andrew; Herbert, David K.; Lian, Yajing; Liu, Fangfang; Liu, Yiyang; Nematalla, Asaad; Piper, Jared L.; Magano, Javier; Monfette, Sebastien; Nguyen, Bao; Raggon, Jeffrey W.; Rainville, Joseph P.; Rane, Anil; Tao, Yong; Wang, Ke; Yayla, Hatice G.:

    Exploratory Process Development of a Pulmonary Arterial Hypertension Clinical Compound via a Late-Stage Pd-Catalyzed Buchwald–Hartwig C–N Coupling

    Image for article: Exploratory Process Development of a Pulmonary Arterial Hypertension Clinical Compound via a Late-Stage Pd-Catalyzed Buchwald–Hartwig C–N Coupling