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Synthesis 2016; 48(11): 1573-1596
DOI: 10.1055/s-0035-1560431
DOI: 10.1055/s-0035-1560431
review
Carbonylations of Alkenes in the Total Synthesis of Natural Compounds
Further Information
Publication History
Received: 05 February 2016
Accepted after revision: 04 March 2016
Publication Date:
31 March 2016 (online)
Abstract
The goal of this review is to highlight the applications of carbonylation reactions of alkenes in the total synthesis of natural compounds. These highly atom-economic reactions, which are known for their industrial applications, constitute attractive synthetic methodologies for the selective construction of carbonyl compounds. We aimed at the selection of recent methodologically attractive syntheses where carbonylations were applied as key steps. In addition, a few examples of the related carbonylation of allenes are shown.
1 Introduction
2 Hydroformylation
3 Hydroaminomethylation and Related Tandem Hydroformylation Reactions
4 Reppe Carbonylation
5 Allylic Carbonylation
6 Oxidative Carbonylation
7 Pauson–Khand Reaction
8 Summary and Outlook
-
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