Synthesis 2004(8): 1253-1256  
DOI: 10.1055/s-2004-822383
PAPER
© Georg Thieme Verlag Stuttgart · New York

Cadmium Chloride: An Efficient Catalyst for One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones

A. Venkat Narsaiah, A. K. Basak, K. Nagaiah*
Organic Chemistry Division, Fine Chemicals Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India
e-Mail: nagaiah@iict.ap.nic.in;
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Publikationsverlauf

Received 13 February 2004
Publikationsdatum:
19. Mai 2004 (online)

Abstract

Biginelli reaction was carried out using cadmium chloride as a catalyst to obtain the dihydropyrimidones in excellent yields. This condensation was applicable to various aldehydes with ethyl acetoacetate and urea in acetonitrile at reflux temperature.