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Synlett 2000; 2000(1): 63-64
DOI: 10.1055/s-2000-6469
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Iron(III)-Catalyzed Synthesis of Dihydropyrimidinones. Improved Conditions for the Biginelli Reaction

Jun Lu* , Huairang Ma
  • *Department of Chemistry, Northwest University, Xian 710069, P.R. China; E-mail: lujunyue@hotmail.com
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Publication Date:
31 December 2000 (online)

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A general and practical route for the synthesis of dihydropyrimidinones 4 by a one-pot condensation of aldehydes, β-keto ester, and ureas is described using ferric chloride hexahydrate-mediated cyclocondensation reaction. Yields are significantly higher than utilizing classical Biginelli reaction conditions.

Biginelli reaction - dihydropyrimidinones - ferric chloride hexahydrate - one-pot condensation - synthesis

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