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Synthesis 2011(22): 3612-3614  
DOI: 10.1055/s-0030-1260241
SHORTPAPER
© Georg Thieme Verlag Stuttgart ˙ New York

An Improved and Alternative Method for the Preparation of Per(6-bromo-6-deoxy)cyclodextrins

Weihua Xue*a, Lifen Zhangb
a School of Pharmacy, Lanzhou University, Lanzhou 730000, P. R. of China
Fax: +86(931)8915686; e-Mail: xuewh@lzu.edu.cn;
b School of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. of China
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Publication History

Received 12 August 2011
Publication Date:
26 September 2011 (online)

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Abstract

A practical and efficient approach to the regioselective synthesis of per(6-bromo-6-deoxy)cyclodextrins is described. The method utilizes the easily accessible (chloro(phenylthio)methylene)dimethylammonium chloride (CPMA), circumventing disadvantages of earlier protocols.

Key words

regioselective bromination - cyclodextrins - CPMA

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