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Synfacts 2011(2): 0183-0183
DOI: 10.1055/s-0030-1259337
DOI: 10.1055/s-0030-1259337
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Enantioselective Synthesis of C 2 and C 1 Dienes
W. C. Boyd, M. R. Crimmin, L. E. Rosebrugh, J. M. Schomaker, R. G. Bergman*, F. D. Toste*
University of California, Berkeley, USA
Further Information
Publication History
Publication Date:
19 January 2011 (online)
Significance
Chiral dienes represent an important class of ligands for several asymmetric transition-metal-catalyzed transformations. Due to this fact the development of efficient and reliable protocols for the preparation of these ligands is an essential objective. In this communication, the authors present an enantioselective synthesis of C 2 and C 1 dienes based on their initial work in the field of stepwise C-H functionalization of alkenes using cobalt dinitrosoalkane complexes (J. Am. Chem. Soc. 2008, 130, 3777). The accessible products 5 can be considered as potentially interesting precursors of new chiral diene ligands.