DOI: 10.1055/s-00000131

Synfacts

Issue 06 · Volume 21 · June 2025 DOI: 10.1055/s-015-61717

Synthesis of Natural Products

z549
All PDFs of this category
549
Total Synthesis of (+)-Saxitoxin
550
Total Synthesis of (–)-Fortalpinoid Q
551
Total Syntheses of Leuconoxine-Type Alkaloids
552
Total Synthesis of (–)-Roxburghine C
553
Total Synthesis of (±)-Harringtonolide
554
Total Synthesis of (–)-Crinipellin A
555
Total Synthesis of (±)-Welwitindolinone A Isonitrile

Synthesis of Heterocycles

z557
All PDFs of this category
557
Synthesis of Aldehydes through the Iron-Mediated Tsuji–Wacker Oxidation of Olefins
558
Indolo-bicyclo[3.1.1]heptanes through an Efficient Fukuyama Radical Indolization Reaction
559
One-Pot Methodology for Efficient Alcohol–Alcohol Cross-Coupling
560
DDQ/EtOAc and O2/H2O Oxidative Systems for Efficient and Scalable Synthesis of Benzoxazoles from Catechols
561
Amine-Ligated Boryl Radicals: Synthesis and Reactivity
562
Synthesis of 4,5-Disubstituted Oxazoles from Carboxylic Acids via [3+2]-Cycloaddition Reaction
563
Stereochemical Editing for the Conversion of a cis- into a trans-Proline Derivative
564
Trifluoroborate to the Rescue: The Development and Coupling of Water-Stable 2-Pyridylation Reagents
565
Rationally Designed Phosphine Ligand to Enable Challenging Palladium-Mediated Aminations
566
Isoselenourea-Catalyzed Self-Correcting Pathway for Enantioselective Pyrazolo-Heterocycle Synthesis
567
Key Role of an Oxidative Addition Complex in Promoting a Pd-Mediated C–S Coupling Reaction
568
A Dual Catalyzed Synthesis of 2-Aminopyrroles from N-Sulfonyl-1,2,3-triazoles
569
Efficient Access to β-Amino Acid Derivatives from Olefins
570
Solvent-Free CuI–Zn(OAc)2-Catalyzed Synthesis of Quinazolin-4(3H)-ones Using Microwave Irradiation

Synthesis of Materials and Unnatural Products

z571
All PDFs of this category
571
Degradable Polysulfones via Migrating Transfer Polymerization
572
Polymer Degradation Enabled by Aromatization-Driven C–C Bond Cleavage
573
Anionic Ring-Opening Polymerization of Vinylidenecyclopropanes
574
Ultra-Long Emissive Indocyanine Polymethines
575
peri-Hexacene: A Diradicaliod
576
Electrophilic Borylation toward Strained Macrocycles
577
9,10-Phenanthrenequinones from a Carbene-Catalyzed Tandem Reaction
578
Lowering the LUMO of a Cyclic (Alkenyl)(Amino)carbene by Substitution with Sulfur
579
Crystalline Keteniminyl Anions
580
A Neutral Boryne

Metals in Synthesis

z581
All PDFs of this category
581
The Aza-Boron-Wittig Reaction: Stereoselective Synthesis of Vinyl Boronates from Amides and Lactams
582
Broadening Arene C–H Alkylations via Radical−Radical Cross-Coupling
583
Nickel-Catalyzed Hydroamidation of Unactivated Alkenes with Isocyanates
584
Enantioconvergent Synthesis of 1,2-Aminoalcohols via Ruthenium Hydrogen Borrowing Catalysis
585
Regioselective syn-Aryltrifluoromethylthiolation of Alkynes under Sequential Nickel and Copper Catalysis
586
Iridium-Catalyzed Enantioselective Hydroarylation via Benzamide Directed C–H Activation
587
Access to Thioamides by Palladium-Catalyzed Coupling of Aryl Chlorides, Isocyanides, and Thiocarboxylates
588
Accessing Diacylated Trisubstituted Aromatic Compounds via a Catellani Reaction
589
Dihaloalkanes as Radical Precursors for the Construction of Cyclic Boronates from Vinyl Boronates
590
Regio- and Enantioconvergent Allylic Substitution of γ-Silyl-Substituted Allyl Acetates with Acrylates
591
Accessing Ester-Substituted Benzofurans via Palladium Cascade Reaction of Alkyne-Tethered Aryl Iodides
592
Enantioselective Decarboxylative Alkyl–Acyl Radical Cross-Coupling of Carboxylic Acids and Aldehydes
593
Cooperative Ligand-Enabled γ-C(sp3)–H Alkenylation of Aliphatic Amides
594
Alkynylcarboxylation of Alkenes with CO2 and Alkynes under Dual Photoredox and Copper Catalysis
595
Functionalization of Aliphatic C–H Bonds through Photochemically Activated Hypervalent Iodine
596
Palladium-Catalyzed Enantioselective Desymmetric β-Hydride Elimination
597
Nickel-Catalyzed Stereoselective C(sp3)–H Alkylation of Saturated Heterocycles
598
Enantioselective Reductive Arylation and Alkenylation of Sulfinylamines to S(IV)-Stereogenic Sulfinamides
599
Photo- or Electrochemical Cyclization of Amino Acid Derived N-Trifluoromethyl Redox-Active Esters
600
Photoredox-Catalyzed 1,2-Amino Migration to Access Unnatural γ-Substituted β-Amino Acids
601
Copper Photocatalysis Enabled Synthesis of Enantioenriched β-Aminoalcohol Derivatives
602
Iron-Catalyzed Oxidative Homocoupling and Cross-Coupling of Organosodium Compounds
603
Asymmetric Dearomative [2+2] Cycloadditions between Naphthalenes and Bicyclobutanes
604
Hydrazides as Versatile Building Blocks in Radical Cross-Coupling
605
Regio- and Enantioconvergent Alkene and Aziridine Coupling under Nickel Photocatalysis
606
Palladium-Catalyzed Direct C(sp2)–H Arylation of Benzene via Concerted Metalation–Deprotonation

Polymer-Supported Synthesis

z607
All PDFs of this category
607
Diverse Functionalization of Electron-Rich Alkenes Using a Carbon Nitride Photocatalyst
608
Selective Synthesis of Primary, Secondary, and Tertiary Amines Using a TiO2-Supported Cobalt Catalyst
609
Nucleophilic Substitution of Allylic Carbonates with Grignard Reagents Using a Cellulose-Supported Cu Catalyst
610
Hydrosilylation of Terminal Alkenes with Tertiary Silanes Using Manganese Nanoparticles
611
Oxidative C–C(O)C Bond Cleavage of Acetophenones with a Single-Atom Copper Catalyst
612
Synthesis of α-Anilinonitriles Using a Cadmium Metal–Organic Framework
613
Photoinduced Hydroalkylation of Alkenes with Alkyl Silicates Using a UiO-Type Metal–Organic Framework
614
Knoevenagel Condensation of Aryl Aldehydes and Malononitrile Using a Gd-Ni Heterometallic Cluster
615
Photocatalytic Oxidative Hydroxylation of Arylboronic Acids with a Phenoxazine-Based Triazine COF
616
Enantioselective CH/CH Cross-Coupling Using a Nickel-L* Complex under Electrocatalytic Conditions
617
Electrochemical Redox Hydrolysis of Cyclic Amines Forming Remote Amino Alcohols

Organo- and Biocatalysis

z619
All PDFs of this category
619
Oxa-π,σ‑Methane Rearrangement for Epoxide Construction via Energy-Transfer Catalysis
620
Vanadium-Dependent Haloperoxidase Catalyses Synthesis of 1,2,4-Thiadiazole via Halide Recycling
621
Photocatalytic [3+2] Cycloaddition of Olefins with Carboxylic Acids
622
Conformationally Tuned Peptidyl HAT Catalysts Enable Enantioselective Hydrodifluoroalkylation of Alkenes
623
Enantioselective Synthesis of α-Fluoro Ketones via Substitution of α-Keto Sulfonium Salts with CsF
624
Radical-Mediated, Catalytic Carbohydroxylation of α‑Olefins
625
Enantioselective Contra-Thermodynamic Positional Isomerization of α,β-Unsaturated Esters
626
Asymmetric Photoredox-Catalyzed Minisci Reactions via Kinetic Resolution of Racemic Radicals
627
Chemoselective Aerobic Oxygenation of Heteroarylmethanes to Ketones via Flavin Catalysis
628
Exocyclic, Deconjucative Olefin Relocation
629
Organocatalytic Atroposelective Amidation and Esterification of Carboxylic Acids
630
Stereoselective Desymmetrization of Tetravalent-Boron-Based Fluorescent Molecules

Innovative Drug Discovery and Development

z631
All PDFs of this category
631
Asymmetric Synthesis of 1,5-Bicyclo[2.1.1]hexanes via [2+2]-Photocycloaddition Approach
632
Introducing BT-33, a Fluorinated Lincosamide Antibiotic
633
An Artificial Metalloenzyme Enables Bioorthogonal Pd Catalysis for Light-Independent Cell–Cell Labeling
634
Synthesis of N,N′-Bisindoles via a Domino Aza-Meyer–Schuster/Aza-Michael Sequence
635
Engaging Exposed Carboxylic Acid Side Chains in Son of Sevenless 1 Inhibitors Leads to Enhanced Potency
636
1,2-Dioxane Synthesis from Simple Dienes
637
A Coumarin-Based Fluorescent Sensor for Amino Acid Neurotransmitters
638
Cobalt-Catalyzed C–H Activation Enabling the Synthesis of Fluorescent Pyridoindolones with Two Distinct C–N Axes
639
3‑Oxabicyclo[3.1.1]heptanes: Potential Mimetics of meta-Substituted Phenyl Rings
640
Transient Tethering for Photocatalytic Sugar C–H Bond Functionalization
641
One-Pot Conversion of Primary Alcohols into Silanes
642
A Practical Strategy for the Chemoselective Synthesis of O-Alkylated Serine and Threonine Derivatives
643
Route Design and Optimization towards Complex Macrocyclic Atropisomer AZD5991

Peptide Chemistry

z645
All PDFs of this category
645
Total Synthesis of Tetraselide via Liquid-Phase Peptide Synthesis Using Soluble Hydrophobic Tags
646
The Use of N-Methylimidazolium Sulfinyl Fluoride Hexafluorophosphate (MISF) to Access Oligopeptides
647
Synthesis of 15N-Labeled Amino Acids
648
Synthesis of Peptides Containing a Dehydroalanine Residue from a Cysteine Residue
649
Synthesis of Dibenzofuran α‐Amino Acids from Tyrosine and Serine Derivatives
650
Accessing (Z)-Fluoroalkene Dipeptide Isosteres Diastereoselectively via the Use of Chiral Auxiliaries
651
Synthesis of Unnatural Amino Acids by C–H Arylation through HAT-Metallaphotoredox Catalysis
652
Chan–Lam Coupling for the Late-Stage Functionalization of Histidine-Residue-Containing Peptides
653
Ullmann Coupling for the Late-Stage Functionalization of Trp Residues of Peptides
654
Preparation of Diastereopure Glycopeptide Precursors
655
Heterocyclic Carbon-Centered Radical Addition Reactions for the Synthesis of α-Amino Acid Derivatives

Flow Chemistry

z657
All PDFs of this category
657
Accessing Lithiated Bicyclobutanes via Continuous Flow