DOI: 10.1055/s-00000131

Synfacts

Issue 09 · Volume 20 · September 2024 DOI: 10.1055/s-014-60079

Synform

A135
Zanda, Matteo: SYNFORM ISSUE 2024/09

Synthesis of Natural Products

z0895
All PDFs of this category
0895
Total Synthesis of (+)-Dihydropleurotinic Acid
0896
Synthesis of (+)-Enteropeptin A
0897
Total Synthesis of Sealutomicin C
0898
Total Synthesis of (+)-Alstrostine G
0899
Total Synthesis of (+)-Lirionol
0900
Total Synthesis of (–)-Cyclopamine
0901
First Synthesis of (±)-Retigeranic Acid

Synthesis of Heterocycles

z0903
All PDFs of this category
0903
Bench-Stable Azabicyclo[2.1.1] Piperazinium Salt as a Versatile Synthetic Intermediate
0904
Enzyme-Catalyzed Access to Spiro-Oxazolidinones
0905
Photocatalyzed Enantioselective Access to Oxetanes
0906
Synthesis of 2,3-Dihydrofuro[3,2-c]quinolines via Acid-Mediated Condensation
0907
Versatile, Photochemical Approach to 2-Azanorbornanes
0908
Carboxylic-Acid-Directed Cyclization of N-Protected ω-Amino Acids
0909
Light-Mediated Deoxygenative Hydroalkylation of Olefins
0910
Hectogram Scale Synthesis of Key Prostaglandin Synthesis Intermediate
0911
Regioselective Difluoromethylation of Pyridines through Oxazino-pyridine Intermediates
0912
Synthesis of 2,3-Diaroylquinolines via Copper-Catalyzed [4+1+1] Annulation
0913
Modular Copper-Mediated Synthesis of Imidazolidines and Imidazolidinones
0914
Three-Component Photochemical Construction of Trisubstituted Oxazoles
0915
General Methodology for the α-Alkylation of Cyclic Ketones
0916
Same Substrates, Different Products: Regiodivergent Cycloaddition Pathways to 1,2,3- and 1,3,4-Triazoles

Synthesis of Materials and Unnatural Products

z0917
All PDFs of this category
0917
Enantioselective Syntheses of π-Extended Carbohelicenes
0918
Spiro-Conjugated Chiral Radical Cations
0919
Nucleophilic Perfluoroalkylation Facilitated by 4-Pyridylthioether
0920
Backbone-Editing with Polyesters and Polyurethanes
0921
Triple Suzuki–Miyaura Arylation via Cyclic Iodonium Salts
0922
Joining Carborane with Arenes
0923
‘Click’ Polymerization of Acetal-thiol
0924
Cyclic Polymers with Ultrahigh Molar Mass
0925
‘Cage of Cages’
0926
Kinetic Resolution Polymerization
0927
Single-Atom Skeletal Editing: Turning N into C
0928
Isolable Secondary Carbon Radical

Metals in Synthesis

z0929
All PDFs of this category
0929
Nickel- and Photocatalytic Enantioselective Alkylation of α-Amino C(sp3)–H Bonds
0930
Atroposelective Reductive Coupling of Two ortho-Substituted Aryl Halides under Nickel Catalysis
0931
Synthesis of Oximes by Nickel-Catalyzed Coupling of Nitrates with Organohalides
0932
Palladium-Catalyzed Cascade Reaction to Fused Isoindolinones
0933
Chromium-Catalyzed Enantioselective Addition of α-Chlorinated Esters and Amides to Aldehydes
0934
Nickel-Catalyzed Cine-Substitution of Enolates
0935
Enantioselective Synthesis of Highly Decorated Pyrrolidines Through a Zinc-Catalyzed [3+2] Reaction
0936
Synthesis of Chiral Allylic Alcohols by Enantioselective Alkenylation of Aldehydes Under Cobalt Catalysis
0937
Dearomative 1,2-Hydroamination of Nonactivated Arenes via Copper–Hydride Catalysis
0938
Synthesis of Anilines by Ruthenium/η5-Phenoxo-Catalyzed Condensation of Phenols and Amines
0939
Asymmetric Arylation of Enone Diesters Enabled by Synergistic Copper Catalysis
0940
Selective Palladium Visible Light Catalyzed Ether/Esterification of Allylic C–H Bonds
0941
Gold-Catalyzed Electrophilic Cyclopropenylation of Terminal Alkynes and Vinyl Boronic Acids
0942
Nickel-Catalyzed α-anti-Hydroarylation of Arylpropiolic Acids and Arylboronic Acids
0943
Asymmetric Aminooxygenation of 1,3-Dienes Enabled by Copper Catalysis
0944
Copper-Catalyzed Borylative Cyclization of Unactivated Vinylcyclopropanes
0945
Palladium-Catalyzed Chain-Walking of Alkynyl Alcohols to α,β-Unsaturated Carbonyls
0946
Asymmetric β-Arylation of Aliphatic Alcohols by Merging Relay Catalysis and Dynamic Kinetic Resolution
0947
Palladium-Catalyzed Spirocyclopropanation of gem-Difluoroalkenes
0948
Enantioselective Rhodium-Catalyzed N2-Allylation of Indazoles with Dienyl Allylic Alcohols
0949
Iridium-Catalyzed Allylation of Bis(alkenyl)boronates to Access Enantioenriched Tertiary Allylic Boronic Esters
0950
Separation by Isomerization: Kinetic Resolution of N-Allylic Pyrazoles under Photoexcited Copper Catalysis
0951
Semipinacol Rearrangement of Allylic Alcohols under Dual Photoredox and Cobalt Catalysis
0952
Decarboxylative C(sp3)–O Coupling Enabled by an Iron Ligand-to-Metal Charge Transfer
0953
Nickel/Photoredox-Catalyzed C(sp3)–H Alkenylation
0954
Dearomative Carbonylative trans-1,2-Difunctionali-zation of Arenes via Chromium–Arene Complexes
0955
Synthesis of anti-1,3-Diols: The Evans–Tishchenko Reaction

Polymer-Supported Synthesis

z0957
All PDFs of this category
0957
Pd Nanoclusters Supported on N-Doped Carbon Spheres for Hydrogenation of Phenols and Benzoic Acids
0958
Hydrogenation of Arenes at Room Temperature under 1 atm of Hydrogen Gas by Rh-Pd/C or Rh-Pt
0959
Selective Hydrogenation of Aldehydes and Ketones under Syngas Using Au NPs Supported on CeO2
0960
Solvent-Free Aerobic Oxidation of C(sp3)–H by a Carbon- and PdO-Doped Nb2O5 Photocatalyst
0961
Hydrogenation of Dinitroarenes Catalyzed by Pt Clusters on a Graphene Shell with a Diamond Core
0962
Photocatalytic Thio/Selenocyanation of Indoles Using Lead-Free Cs2AgBiBr6 Double Perovskite MCs
0963
Nickel-Catalyzed C(sp2)–S Cross-Coupling with mpg-CN under Blue LED Irradiation
0964
Dehydrogenative Silacyclization with a Porous Polymer-Supported Iridium Catalyst
0965
Catalytic Transfer Hydrogenation of Carbonyls by SILP-Supported Manganese Nanoparticles
0966
Enantioselective [2+2] Cross-Photocycloaddition Using a Homochiral Metal–Organic Cage Reactor
0967
Photocatalytic Oxidative Bromination of Arenes by Al2O3-Supported Perylenetetracarboxylic Dianhydride

Organo- and Biocatalysis

z0969
All PDFs of this category
0969
Photocalatytic C–H Alkylation Enabled by a Zwitterionic Acridinium Amidate Catalyst
0970
Asymmetric Synthesis of Seven-Membered N-Heterocycles and Carbocycles
0971
Alcohol-Directed Functionalization of Remote C–H Bonds
0972
Organocatalytic Asymmetric Epoxidation of Alkenyl Aza-Heteroarenes
0973
Consecutive Photoinduced Electron Transfer Enables Asymmetric [3+2] Cycloadditions
0974
Confined Acid Catalyzes the Enantioselective Hydroamination of Non-Activated Olefins
0975
Solid-State Preorganization Enables Highly-Selective [2+2] Cycloaddition towards Truxillates
0976
Organophotocatalytic Method for Synthesis of α-Amino Bicycloalkanes – Pharmaceutically Relevant Molecules
0977
Synergistic Catalytic Asymmetric Decarboxylation of β-Keto Acids with Acyclic α-Arylenamides
0978
Photoorganocatalytic Reduction of Esters to Alcohols

Innovative Drug Discovery and Development

z0979
All PDFs of this category
0979
Synthesis and Medicinal Chemistry of Veragranine Alkaloids
0980
Functionalization of Oxetanes with C/N/O/S Nucleophiles – Convenient Access to Carbonyl Isosteres
0981
High-Throughput Access to Libraries of N-Acylsulfamide Derivatives, a Bioisostere of Carboxylic Acids
0982
Amination of Arenes Using Blue Light and Lewis Acids
0983
Vinylpyridine Based Covalent EGFR Inhibitors
0984
Photochemical Conversion of Pyridines into Diazepines, Pyrazolines and Pyrazoles
0985
Divergent Synthesis of 2- and 3-Azabicyclo[3.1.1]heptenes as Bioisosteres of Pyridines
0986
Development of the Photoresponsive Drug via Caging Triarylimidazoles
0987
An Eight-Step Total Syntheses of Clausenawallines A and E are Enabled by High-Throughput Experimentation
0988
HRO761: a First-in-Class Non-Covalent WRN Inhibitor with Synthetic Lethality in MSI Cancers
0989
A Modified Arbuzov–Michaelis Reaction for Chemoselective Alkylations
0990
New Method for the Highly Enantioselective Synthesis of cis-Hydrobenzofurans and cis-Hydroindoles
0991
Synthesis of a Selective Co-factor to Investigate Methyltransferase Activity
0992
Subcellular Uncaging of H2S and Drug with NIR Light
0993
Diverse Synthesis of C‑Glycosides by Stereoselective Ni-Catalyzed Carboboration of Glycals
0994
Expanding Chemical Space One Carbocycle at a Time

Peptide Chemistry

z0995
All PDFs of this category
0995
N-Methylated Peptide Synthesis Using Flow Chemistry
0996
α,α-Disubstituted Unnatural Amino Acid Synthesis Using Photochemical Carboxylation
0997
Chiral Phenanthroline-Potassium-Catalyzed Synthesis of Axially Chiral Biaryl δ-Amino Acid Derivatives
0998
Utilizing Cyclen Installation as an Efficient Strategy for Macrocyclization and Multifunctionality of Peptides
0999
Synthesis of Proline Derivatives via [1,2]-Stevens Rearrangement of Azetidinium Salts
1000
Synthesis of Unprotected α-Tertiary Amino Acids Using Synergistic Photoenzymatic Catalysis
1001
Macrocyclic Thiazol(in)e Peptide Synthesis from Peptide Nitriles Using a Biocompatible Strategy
1002
Electrochemical Modification of Tryptophan and Tryptophan-Containing Peptides
1003
Tertiary Amine Catalyzed Late-Stage Tryptophan Allylation of Peptides
1004
Synthesis of Functionalized Diketopiperazines
1005
Photocatalyzed Synthesis of Unnatural α-Amino Acids
1006
Asymmetric Synthesis of α,α-Disubstituted α-Amino Acid Esters via Tsuji–Trost Allylation
1007
O-Hydroxybenzenesulfonyl Chloride Mediated Peptide Synthesis

Flow Chemistry

z1009
All PDFs of this category
1009
Photocatalyst-, Oxidant-, Additive-Free Nitrosylation Using Continuous Flow/Photochemical Conditions