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Synthesis 2022; 54(20): 4503-4508
DOI: 10.1055/a-1863-4082
DOI: 10.1055/a-1863-4082
paper
A Sequential Cycloisomerization/Oxidative Aromatization of 2-Propargyl-cyclohexenones for Direct Access to Substituted Benzofurans
C.R.R. thanks the Science and Engineering Research Board (SERB), New Delhi (EMR/2016/006253), for funding this project. Y.L.P. thanks the Department of Science and Technology (DST) for a financial grant under the Women Scientists Scheme-A (WOS-A) [Grant No. SR/WOS-A/CS-108/2017 (G)]. K.W. thanks the Council of Scientific and Industrial Research (CSIR), New Delhi and K.N. thanks the Department of Science and Technology (DST), New Delhi for research fellowships (DST-INSPIRE/03/2018/001878).
CSIR-IICT Communication No. IICT/Pubs./2022/084
Abstract
A new approach for the synthesis of benzofurans starting from non-aromatic precursors is reported. The reaction involves sequential DBU-mediated cycloisomerization for furanylation followed by benzene ring construction via oxidative aromatization in the presence of Oxone®. Atom- and pot-economy, simple reaction conditions, the straightforward preparation of starting materials and access to diverse substituted benzofurans are the major advantages of this reaction.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1863-4082.
- Supporting Information
Publication History
Received: 11 March 2022
Accepted after revision: 27 May 2022
Accepted Manuscript online:
27 May 2022
Article published online:
05 July 2022
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