Recent Advances in the Transition-Metal-Free Arylation of Hetero­arenes

Abstract

Transition-metal-free arylation reactions have attracted considerable attention for economic and environmental reasons over the past 40 years. In recent years, much effort has been made to develop efficient transition-metal-free approaches for the arylation of heteroarenes. Covering the literature from 2015 to early 2021, this review aims to provide a thorough overview of the synthetic and mechanistic aspects of these atom-economical and environmentally benign reactions.

1 Introduction

2 Arylation of Pre-functionalized Heteroarenes

2.1 Arylation of Heteroaryl Halides

2.2 Decarboxylative Arylation of Heteroarenes

3 Direct C–H Arylation of Heteroarenes

3.1 C(sp²)–H Arylation

3.2 C(sp³)–H Arylation

4 N-Arylation of Heteroarenes

5 Summary and Outlook

Key words

transition-metal-free reactions - arylation - heteroarenes - C–H functionalization

Publication History

Received: 03 April 2021

Accepted after revision: 02 July 2021

Accepted Manuscript online:
02 July 2021

Article published online:
20 August 2021

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