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Synthesis 2021; 53(23): 4353-4374
DOI: 10.1055/a-1543-3743
DOI: 10.1055/a-1543-3743
short review
Recent Advances in the Transition-Metal-Free Arylation of Heteroarenes
This study was funded by Türkiye Bilimsel ve Teknolojik Araştirma Kurumu (The Scientific and Technological Research Council of Turkey, TUBITAK; project no. 216Z168). We would like to thank TUBITAK for its support.
Abstract
Transition-metal-free arylation reactions have attracted considerable attention for economic and environmental reasons over the past 40 years. In recent years, much effort has been made to develop efficient transition-metal-free approaches for the arylation of heteroarenes. Covering the literature from 2015 to early 2021, this review aims to provide a thorough overview of the synthetic and mechanistic aspects of these atom-economical and environmentally benign reactions.
1 Introduction
2 Arylation of Pre-functionalized Heteroarenes
2.1 Arylation of Heteroaryl Halides
2.2 Decarboxylative Arylation of Heteroarenes
3 Direct C–H Arylation of Heteroarenes
3.1 C(sp2)–H Arylation
3.2 C(sp3)–H Arylation
4 N-Arylation of Heteroarenes
5 Summary and Outlook
Publikationsverlauf
Eingereicht: 03. April 2021
Angenommen nach Revision: 02. Juli 2021
Accepted Manuscript online:
02. Juli 2021
Artikel online veröffentlicht:
20. August 2021
© 2021. Thieme. All rights reserved
Georg Thieme Verlag KG
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