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Synthesis 2020; 52(14): 2008-2016
DOI: 10.1055/s-0039-1690890
DOI: 10.1055/s-0039-1690890
short review
Brominated β-Alkoxyvinyl Trihalomethyl Ketones as Promising Synthons in Heterocyclic Synthesis
The authors are grateful for financial support from the Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS/CNPq – PRONEX, Grant No. 16/2551-0000477-3) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Grant No. 407898/2018-2).Weitere Informationen
Publikationsverlauf
Received: 11. Februar 2020
Accepted after revision: 16. März 2020
Publikationsdatum:
14. April 2020 (online)
Abstract
5-Bromo- and 5,5-dibromo-1,1,1-trihalo-4-methoxypent-3-en-2-ones (brominated enones) have proven to be attractive building blocks for the construction of heterocyclic and polyheterocyclic compounds bearing a trihalomethyl moiety through interesting cyclocondensation, alkylation, and cycloaddition reactions. This review compiles all of the reactions conducted with these brominated enones since they were first disclosed in 2001.
1 Introduction
2 Synthesis and Initial Applications
3 Synthesis Using First-Generation Intermediates
4 Synthesis Using Second-Generation Intermediates
5 Synthesis Using Third-Generation Intermediates
6 Conclusions
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