Iron Catalysis in Target Synthesis

Abstract

The use of iron-catalysed organic transformations in the total syntheses of natural products has increased significantly. Iron-catalysed cross-coupling reactions are now widely applied in total syntheses and many other transformations, such as alkene functionalisation, oxidation, and cyclisation. The development of these processes, as well as many examples of their use in target synthesis, is presented here.

1 Introduction

2 Cross-Coupling Reactions

3 Functionalisation of Unactivated Alkenes

4 Carbocyclisation Reactions

5 Oxidations

6 Further Examples

7 Conclusions

Key words

alkene functionalisation - carbocyclisation - cross-coupling - drug molecule synthesis - iron catalysis - natural product synthesis - oxidation - transition metal catalysis

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