Abstract
This review article summarizes the fundamental synthetic procedures aimed at the preparation
of unsymmetrical bisindolylmethanes that have appeared in the literature since 2010.
To this goal, reactive electrophilic indole-containing intermediates are mostly generated
from indolylmethanols, indolylmethanamines, and indolylmethanthio derivatives and
then made to react with simple or functionalized indoles. The asymmetric synthesis
of bisindolylmethanes can be also achieved under chiral-catalyzed conditions.
1 Introduction
2 Direct Three-Component Coupling
3 Reaction of Indolylmethanols
4 Reaction of Indolylmethanamine Derivatives
5 Reaction of 3-Vinylindoles
6 Reaction of indolylmethanthio Derivatives
7 Bisindolylmethanes by Ring Closure of Alkyne Derivatives
8 Miscellaneous Methods
9 Conclusion
Key words asymmetric synthesis - bisindolylmethanes - chiral catalysis - electrophilic substitution
- indoles
