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Synthesis 2018; 50(05): 968-983
DOI: 10.1055/s-0036-1591877
DOI: 10.1055/s-0036-1591877
short review
Perspective on FTY720, an Immunosuppressant
Weitere Informationen
Publikationsverlauf
Received: 05. Oktober 2017
Accepted after revision: 23. November 2017
Publikationsdatum:
24. Januar 2018 (online)
Dedicated to Professor Indrapal Singh Aidhen
Abstract
FTY720 {fingolimod hydrochloride, 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride}, a novel immunosuppressant, was discovered by chemical modification based on the structure activity relationships of ISP-I (myriocin), a metabolite of the fungus Isaria sinclairii. This short perspective provides insights to the various strategies available in the literature for the synthesis of FTY720 and its analogues.
1 Introduction
2 Classification of Immunosuppressive Drugs
3 The Rise of FTY720
4 Different Synthetic Strategies for FTY720
5 Analogues of FTY720
6 Binding Studies of FTY720
7 Mode of Action
8 Conclusion
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