Transition-Metal-Catalyzed
C-H Functionalization for the Synthesis of Substituted
Pyridines

Yoshiaki Nakao

doi:10.1055/s-0030-1260212

REVIEW

Transition-Metal-Catalyzed C-H Functionalization for the Synthesis of Substituted Pyridines

Yoshiaki Nakao*
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan
Fax: +81(75)3832443; e-Mail: yoshiakinakao@npc05.mbox.media.kyoto-u.ac.jp;

Abstract

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Abstract

The direct functionalization of pyridine and related azine derivatives through carbon-carbon bond-forming reactions is reviewed. Various transformations that use a variety of transition-metal catalysts are covered, including alkylation, alkenylation, arylation, and acylation. In addition to the conventionally observed C2-selectivity for these transformations, recent developments involve selective introduction of newly formed carbon-carbon bonds to the C3- and C4-positions of pyridine and azine nuclei. The reaction scope and a proposed mechanism for each transformation are briefly summarized.

1 Introduction

2 C2-Selective Functionalization

3 C3-Selective Functionalization

4 C4-Selective Functionalization

5 Conclusions

Key words

pyridine - C-H functionalization - alkylation - alkenylation - arylation - acylation - transition-metal catalysis

Full Text

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