Enantioselective Reactions of Redox-Active Esters Catalyzed via Cooperative Photoredox/Chiral Phosphoric Acid Catalysis

Abstract

Redox-active esters have garnered significant interest owing to their bench stability and photochemical reactivity. When combined with photoredox and chiral phosphoric acid catalysis, these esters enable the formation of new carbon–carbon bonds while concurrently inducing chirality. Since the pioneering enantioselective Minisci-type addition reported by Phipps, substantial progress has been achieved in this promising field. This review summarizes the developments and mechanistic insights accumulated over the past decade, offering perspectives on future research directions.

Keywords

Asymmetric catalysis - Chiral phosphoric acid - Friedel−Crafts reaction - Minisci reaction - Photoredox catalysis - Radical reaction - Redox-active ester

Publication History

Received: 20 June 2025

Accepted after revision: 03 August 2025

Accepted Manuscript online:
03 August 2025

Article published online:
22 September 2025

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