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Synlett
DOI: 10.1055/a-2531-7183
DOI: 10.1055/a-2531-7183
letter
Small Molecules in Medicinal Chemistry
Synthesis and Evaluation of Bakuchiol-Tethered Triazoles as Cytotoxic Agents
NS is thankful to the National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, the Ministry of Chemicals and Fertilizers, India for the award of junior and senior research fellowships. RK and JC thank Council of Scientific and Industrial Research, India (CSIR, 02/0397/2021/EMR-II) for financial support.
Abstract
A novel series of bakuchiol-tethered triazole compounds was synthesized by reaction of azido bakuchiol with different substituted alkynes. The anticancer activity of all synthesized compounds was evaluated against A549 (lung), MCF-7, and MDA-MB-231 (breast) human tumor cells. Cytotoxicity screening showed that several compounds displayed notable cytotoxic effects against tumor cells compared to the parent molecule bakuchiol. The prominent effects were produced by compounds with IC50 values of 8.9 μM and 8.2 μM against the MCF-7 and A-549 cells, respectively.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2531-7183.
- Supporting Information
Publication History
Received: 02 December 2024
Accepted after revision: 03 February 2025
Accepted Manuscript online:
03 February 2025
Article published online:
21 March 2025
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