Synlett

Shaw, Suman K.; Borisa, Ankit; Dixit, Nandan; Patel, Saumya; Bhatt, Hardik G.:

Expanding the Horizon of Pteridine Chemistry: Optimized Synthesis by the Isay Reaction, and Molecular-Docking Studies

MacQueen, Jordan; Billingsley, Kelvin L.:

Indolactam Alkaloids: Syntheses and Emerging Therapeutic Applications

Sharma, Anu; Vadodariya, Palak K.; Vaddoriya, Vaidehi N.; Dhameliya, Tejas M.:

Comprehensive Updates on Antitubercular Endeavors Identified in 2023

Abonia, Rodrigo; Laali, Kenneth K.:

A Tale of Drug Discovery: Synthesis, Bioassay, and Computational Docking Studies of Novel Curcuminoids

Thaker, Aanal; Patel, Shrusti; Dey, Rajdeep; Shaw, Suman; Bhatt, Hardik; Patel, Bhumika; Chaube, Udit:

Advancements in mTOR Inhibitors for Non-Small-Cell Lung Cancer: Mechanisms, Efficacy, and Future Perspectives

Pal, Deepti; Yadav, Shruti; Verma, Abhishek Kumar; Maurya, Sushil K.:

Recent Developments in the Synthesis of Triazoles and Their Applications in Antibacterial Drug Discovery

Majhi, Sasadhar:

Sustainable Approaches for the Synthesis of Functionalized Xanthene Derivatives with Anticancer Activities Using Modern Green Tools at Room Temperature: Less Energy and More Efficiency

Sanjaykumar, Randhe Siddhant; Basavaraj, Chavan Sagar; Arshad, Anam Sania Md.; Singh, Rohit; Mahindroo, Neeraj:

A Decade of FDA-Approved Pharmacophore-Based Small Molecules: Advances in Medicinal Chemistry from 2014 to 2024

Chandra, Devesh; Sachin, Sachin; Rav, Shourabh; Sharma, Upendra:

Quinoline-Based FDA-Approved Drugs: Synthetic Route and Clinical Uses

Garg, Aakriti; Bhattacharya, Bireswar; Samanta, Uttam; Singha, Subhankar; Ghosh, Dipanjan; Bhowmik, Subhendu; Jaisankar, Parasuraman; Gupta, Sreya:

Phototriggered Migration of Indole-Based Cationic Fluorophore from Mitochondria to Nucleolus in Live Cells

Alaeddini, AmirHossein; Karimian, Somaye; Noori, Milad; Dastyafteh, Navid; Mohammadi-Khanaposhtani, Maryam; Ghomi, Minoo Khalili; Bararjanian, Morteza; Iraji, Aida; Javanshir, Shahrzad; Larijani, Bagher; Ranjbar, Parviz Rashidi; Mahdavi, Mohammad:

Design, Synthesis, Enzymatic Inhibition, and Antioxidant Activity of New 4-Phenylpiperazin-phenoxy-1,2,3-triazol-acetamide Derivatives as Tyrosinase Inhibitors

Ito, Toshiya; Kinoshita, Kazutomo; Tomizawa, Masaki; Shinohara, Shojiro; Nishii, Hiroki; Tanaka, Hiroshi; Kuramoto, Shino; Oikawa, Nobuhiro:

Development of a Novel Tropomyosin Receptor Kinase Inhibitor Based on Structure–Activity Relationships: Identification of a Promising Clinical Candidate

Haque, Rajibul; Ghosh, Souma; Banerjee, Rajkumar; Maity, Debabrata:

Reactive Probe for Fluorescent Detection of Norepinephrine Based On an Excited-State Intramolecular Proton Transfer (ESIPT) Mechanism

Shaw, Suman K.; Dey, Rajdeep; Yadav, Ruchi; Baldiwala, Aliasgar; Patel, Manan; Patel, Bhumika D.; Bhatt, Hardik G.; Natesan, Gopal; Jha, Abhishek; Chaube, Udit:

Exploring Tetrahydroquinoline Derivatives: A New Frontier in Cancer Treatment

Roy, Sudipta; Kalita, Gitumoni; Maharana, Satyapriya; Chatterjee, Arunima; Jana, Rathin; Nath, Naba K.; Chatterjee, Paresh Nath:

A Green Approach to 2-Amino-4H-chromenes by Calcium Lactate Catalyzed, One-Pot, Three-Component Reactions

Peprah, Paul K.; Spitznagel, Brittany D.; Du, Yu; Nguyen, Dalena; Weaver, C. David; Emmitte, Kyle A.:

Efficient Regioselective Synthesis of Benzimidazoles and Azabenz­imidazoles to Enable the Rapid Development of Structure–Activity Relationships for Activation of SLACK Potassium Channels

Chvatal, Jo; Nguyen, Dat T.; Xie, Alexondra S.; Parsons, William H.:

Synthesis and Evaluation of N-Arylsulfonylated Succinimides as Activity-Based Probes

Das, Debojyoti; Sadhukhan, Juheli; Mandal, Pabitra; Pramanik, Smritimoy; Kabir, Alomgir Shah; Adhikari, Susanta Sekhar:

Synthesis of Novel Coumarin-Appended Dihydrothiopyrimidinones and Evaluation of Their Binding Interactions with Bovine Serum Albumin

Milokhov, Demyd S.; Pomalin, Mykhailo S.; Lutsiuk, Tetiana M.; Hys, Vasyl Y.; Virych, Pavlo A.; Poliudov, Anton O.; Popova, Maria V.; Shishkina, Svitlana V.; Volovenko, Yulian M.; Dobrydnev, Alexey V.:

Benzo[d][1,2]thiazepin-5-one 3-Oxides: An Unexplored Scaffold with Anticancer Activity

Şenol, Halil; Çağman, Zeynep; Çakır, Furkan; Tokalı, Feyzi Sinan:

Synthesis, Characterization, and In Vitro and In Silico Biological Evaluation of Novel Polyphenols Bearing a Quinazolin-4(3H)-one Ring as Promising Anti-Prostate-Cancer Agents

Khanka, Sonu; Rawat, Kundan S.; Pandey, Priyanka; Pal, Shyamal; Vats, Ravi P.; Rathur, Rajat; Sharma, Kriti; Dipali, Divya; Singh, Divya; Goel, Atul:

An Efficient Synthesis of 3-Aryl-2H-chromene Derivatives as Potential Bone Anabolic Agents

Shaikh, Arbaz Sujat; Rathod, Mahipal Singh; Vemula, Divya; Makhal, Priyanka N.; Bhandhari, Vasundhara; Kaki, Venkata Rao:

Metal-Free Amidation and Selenoamidation of 2-Methylquinolines with Secondary Amines Using Selenium Dioxide, and Antibacterial Evaluation of the Products

Sengar, Neha; Chatterjee, Joydeep; Kumar, Raj; Singh, Inder Pal:

Synthesis and Evaluation of Bakuchiol-Tethered Triazoles as Cytotoxic Agents

Toledano-Pinedo, Mireia; Diez-Iriepa, Daniel; Porro-Pérez, Alicia; Schäker-Hübner, Linda; Hanl, Maria; Samadi, Abdelouahid; Almendros, Pedro; Iriepa, Isabel; Rodríguez-Fernández, M. Mercedes; Griñán-Ferré, Christian; Siwek, Agata; Wolak, Małgorzata; Satała, Grzegorz; Bojarski, Andrzej J.; Doroż-Płonka, Agata; Handzlik, Jadwiga; Godyń, Justyna; Knez, Damijan; Gobec, Stanislav; Więckowska, Anna; Hansen, Finn K.; Marco-Contelles, José:

Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative

Candito, David A.; Simov, Vladimir; Liu, Ping; Ardolino, Michael J.; Martinot, Theodore; Lyons, Thomas; Qi, Ji; Yin, Jingjun; Hao, Jinglai; Hu, Bin; Chen, Meng; Zhang, Jun; Lam, Yu-hong; Fuller, Peter H.; Ellis, J. Michael; Maddess, Matthew:

A Concise Synthesis of a Key Azabicyclo[2.1.1]hexane Building Block for N-Heteroaryl Indazole LRRK2 Kinase Inhibitors

Beveridge, Julia; Söderström, Marcus; Balestri, Lorenzo Jacopo Ilic; Prieto-Díaz, Rubén; Gutierrez-de-Teran, Hugo; Odell, Luke R; Hallberg, Mathias; Larhed, Mats; Gising, Johan:

Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations

Purohit, Priyank; Bhatt, Akanksha; Mittal, Ravi Kumar:

Ruthenium-Based Small-Molecule Complexes: A Promising Approach for Drug Discovery

Kumar, Ch. N. S. Sai Pavan; Jayathirtha, Vaidya Rao:

Bioactive Molecules via Morita–Baylis–Hillman Chemistry

Kobayakawa, Takuya; Yamamoto, Kenichi; Fukutome, Aiichiro; Arioka, Marisa; Tsuji, Kohei; Tamamura, Hirokazu:

Design and Synthesis of a C₂-Symmetric Cyclic Decapeptide and Its Peptidomimetic as Potential Inhibitors against Amyloid-β Aggregation

Seaton, Wesley B.; West, Clayton; Burke, Susan J.; Schilletter, William A.; Tade, Opeyemi O.; Collier, J. Jason; Campagna, Shawn R.:

Design, Synthesis, and Biological Evaluation of Thioether Steroids as Glucocorticoid Receptor Modulators

Tomohara, Keisuke; Nose, Takeru; Nambu, Hisanori:

Straightforward Synthesis of Unnatural α,α-Disubstituted α-Amino Acid Derivatives Using Readily Accessible Building Blocks

Chaudhury, Subhabrata; Wetzel, Edward A.; Elmansy, Mohamed F.; Hanson, Alicia M.; Brown-Ford, Sandra; Gleason, Alexandra; Perera, K. L. Iresha Sampathi; Sem, Daniel S.; Donaldson, William A.:

Analogues of the Potent and Selective ERβ Agonist trans-4-(4-Hydroxyphenyl)cyclohexanemethanol: Synthesis and Evaluation

Kumar, Ankur; Debnath, Utsab; Roy, Kuldeep K.:

Thiazole-Scaffold-Based Anti-tubercular Agents: A Review on Synthesis and Structural Modifications

Gcabashe, Nontobeko; Kumar, Gobind; Seboletswe, Pule; Manhas, Neha; Singh, Parvesh:

A Rapid, Greener, and Sustainable Synthesis of N-Acylhydrazones of Isoniazid in a Deep-Eutectic Solvent

Goel, Kapil Kumar; Singhal, Peeush; Marianesan, Arockia Babu; Pandey, Sarvesh Kumar; Kumar, Roshan; Singh, Thakur Gurjeet; Tyagi, Yogita; Gaidhane, Shilpa; Singh, Mahendra Pratap; Dwivedi, Ashish Ranjan:

A Decade of Piperazine-Based Small Molecules Approved by U.S. FDA: Exploring the Medicinal Chemistry Impact of this Versatile Pharmacophore

Kushwaha, Pragati; Rashi, Rashi; Bhardwaj, Ayush; Khan, Danish:

Advances in Synthesis and Anti-Alzheimer’s Disease Potential of Functionalized Benzofurans: A Recent Overview

Chuchvera, Yaroslav O.; Korobka, Oleksandr P.; Horbatochkin, Yurii O.; Ostapchuk, Eugeniy N.; Popova, Maria V.; Shishkina, Svitlana V.; Volovenko, Yulian M.; Dobrydnev, Alexey V.:

Synthesis of 5-Functionalized 1-(Hetero)Aryl-1,2-thiazine 1-Oxides through a CSIC Reaction Strategy

Dastari, Sowmya; Panda, Biswajit; Rasane, Sai; Reddyrajula, Rajkumar; Godugu, Chandraiah; Shankaraiah, Nagula:

Design, Synthesis, and In Vitro Cytotoxicity Studies of 1H-Benzimidazol-2-yl–Enaminone Hybrids as Tubulin Polymerization Inhibitors

Pumirat, Pattarapon; Sripraphot, Supang; Nilchan, Napon; Jiarpinitnun, Chutima:

Squaramide Homoserine Lactone Derivatives and their Abilities to Modulate Pseudomonas aeruginosa Biofilm Formation

Okon, Aniekan; Morgunov, Anton; Yang, Jinyi; Petri, Yana D.; Kilgore, Henry R.; Li, Yanfeng; Strieter, Eric R.; Raines, Ronald T.:

Hydrophilic α-Aryl-α-Diazoamides for Protein Esterification

Sakamoto, Masaharu; Kai, Seriha; Tateishi, Hiroshi; Biswas, Tanima; Sakamoto, Takashi; Teshima, Misaki; Iwanaga, Misaki; Nishikawa, Akiko; Sakamoto, Arisa; Shimozono, Rie; Kameyama, Hiroki; Nambu, Masami; Masunaga, Takuya; Anraku, Kensaku; Fujita, Mikako; Otsuka, Masami:

Oxaprozin and SB-431542 Hybrid Molecule Inhibits Fibrosis and Cancer Cell Migration

Saliba, Paul; Hurem, David; Begovic, Lila; McNulty, James:

(Methylcarboxymethylene)tripropylphosphorane: A Stabilized Ylide for Rapid Formation of Methyl Vinyl Ketones and Applications in Medicinal Chemistry and Natural Product Synthesis

Nazir, Habiba; Naseer, Muhammad Moazzam:

The Isatin Scaffold: Exceptional Potential for the Design of Potent Bioactive Molecules

Chakraborty, Kaustav; Dasgupta, Swagata; Pathak, Tanmaya:

Pyrimidine Carboxylic Acids Linked through 1,4,5-Trisubstituted 1,2,3-Triazoles: Synthesis and RNase A Inhibition Studies

Khan, Tahmeena; Raza, Saman; Hashmi, Kulsum; Ahmad, Mohammad Imran; Khan, Abdul Rahman:

Structural Modifications for Biological Activity Enhancements in Thiosemicarbazone Scaffolds and Their Metal Complexes

Ateşoğlu, Şeyma; Çakır, Furkan; Şenol, Ayşe Merve; Tokalı, Pelin; Şenol, Halil; Tokalı, Feyzi Sinan; Akbaş, Fahri; Kalay, Erbay:

Synthesis, Characterization and In Vitro and In Silico Biological Evaluation of New Mannich-Based Rhodanine and Thiazolidine-2,4-dione Derivatives as Potential Anti-Lung-Cancer Agents

Garg, Mansi; Verma, Ekta; Mishra, Shweta; Sahu, Adarsh:

Advancements in Isoniazid-Based Heterocyclic Derivatives as Potent Antitubercular Agents: A Comprehensive Review of Synthesis, SAR, and Biological Activity (2017–2023)

Thien, Nguyen Duc; Ngoc, Hoang Kim; Nam, Nguyen-Hai; Anh, Duong Tien; Baecker, Daniel:

A Novel Strategy for the Synthesis of N-Alkylated Oxindoles

Rai, Aman; Soni, Arti; Bhatia, Rohit:

Design, Synthesis, and Molecular Docking Studies of Sulfonyl-Substituted Chromene Derivatives as Anticancer Agents

Ghosh, Priyam; Mukhopadhyay, Sayantani; Singh, Mrinalini; Ghosh, Siddhartha Sankar; Iyer, Parameswar Krishnan:

Exploring the Dual Therapeutic Potential of a Photoactivatable AIEgen in Cancer and Alzheimer’s Disease

Martinez, Alice K. de A.; Mourão, Penina S.; Corrêa, Arlene G.:

A Concise Account on Organocatalyzed Asymmetric Synthesis of Epoxide and Aziridine Derivatives from α,β-Unsaturated Carbonyl Compounds

Alzahrani, Abdullah Y. A.; El-Helw, Eman A. E.; Ramadan, Sayed K.:

Some Thiazolopyrimidine Derivatives: Synthesis, DFT, Cytotoxicity, and Pharmacokinetics Modeling Study