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Synthesis 2025; 57(09): 1583-1591
DOI: 10.1055/a-2492-3240
DOI: 10.1055/a-2492-3240
feature
Synthesis of Isatins via Oxone®/TBAI-Mediated On-Water Oxidation of Indoles
Authors
This work was financially supported by the Council of Scientific and Industrial Research, India (CSIR, India) via Project Nos. HCP23 and HCP50. P.K. thanks CSIR for a fellowship. D.B. thanks CSIR-IIIM and CSIR-NCL for fellowships.
Abstract
Isatins and their derivatives are important scaffolds in a wide range of pharmaceuticals, bioactive compounds, and functional materials. Herein we describe a new strategy for the synthesis of isatins from indoles via Oxone®/TBAI-mediated oxidative dearomatization of indoles in water. The strategy works well with a variety of N-protected indoles and azaindoles.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2492-3240.
- Supporting Information (PDF)
Publication History
Received: 25 September 2024
Accepted after revision: 28 November 2024
Accepted Manuscript online:
28 November 2024
Article published online:
07 January 2025
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