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Synlett
DOI: 10.1055/a-2283-0623
DOI: 10.1055/a-2283-0623
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Carbohydrate Chemistry in China
Advances on the Synthesis of C-Aryl-glycosides Since 2019
The authors are grateful for financial support provided by the National Natural Science Foundation of China (NSFC) (22125103), the Science and Technology Commission of Shanghai Municipality (STCSM) (22JC1401000), and the China Postdoctoral Science Foundation (2023M731094 and BX20230127).
Abstract
Aryl-glycosides represent a significant subclass of crucial glycosidic compounds, increasingly capturing the attention of pharmaceutical developers as bioelectronic motifs embedded within glycosides. Their outstanding resistance to enzymatic hydrolysis bestows a distinctive advantage in the field of drug development, particularly in therapeutic domains such as diabetes treatment, where pharmaceuticals based on the C-aryl-glycoside architecture manifest compelling therapeutic efficacy. As a result, researchers in the realm of synthetic chemistry have diligently explored and devised a plethora of streamlined and efficacious synthetic methodologies. This comprehensive account systematically delineates methodologies employed in recent years for the efficient synthesis of C-aryl-glycosides, offering insights into three primary directions: transition-metal catalysis, radical strategies, and metal-free catalysis processes.
1 Introduction
2 Glycosylation via Transition-Metal Catalytic Approaches
3 Glycosylation via Glycosyl Radical Approaches
4 Glycosylation via Metal-Free Catalytic Approaches
5 Conclusion and Outlook
Key words
C-aryl-glycosides - glycosylation - transition-metal catalysis - glycosyl radical - metal-free catalysisPublication History
Received: 21 January 2024
Accepted after revision: 07 March 2024
Accepted Manuscript online:
07 March 2024
Article published online:
20 March 2024
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