Synthesis 2019; 51(23): 4359-4365
DOI: 10.1055/s-0039-1690694
© Georg Thieme Verlag Stuttgart · New York

Scalable Synthesis of Acridinium Catalysts for Photoredox Deuterations

Bouthayna Zilate
Lukas Schneider
Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland   Email: [email protected]
› Author Affiliations
We gratefully acknowledge the Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) and the Department of Chemistry of the University of Basel for financial support.
Further Information

Publication History

Received: 23 August 2019

Accepted after revision: 12 September 2019

Publication Date:
21 October 2019 (online)


The continuous development of photocatalytic methods incentivizes the design of organic catalysts to complement the frequently used and precious polypyridyl transition metal systems. Herein, a scalable synthesis of suitable acridinium dyes and their application in photoredox deuterations are described. The acridinium catalysts, prepared on multi-gram scale, allowed the deuteration of a pharmaceutically relevant scaffold in high yield and selectivity under mild conditions.

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