Recent Advances in the Application of Ring-Closing Metathesis for the Synthesis of Unsaturated Nitrogen Heterocycles

Emilia J. Groso; Corinna S. Schindler

doi:10.1055/s-0037-1611651

Synthesis, Table of Contents

CC BY ND NC 4.0 · Synthesis 2019; 51(05): 1100-1114
DOI: 10.1055/s-0037-1611651

short review

Copyright with the author

Recent Advances in the Application of Ring-Closing Metathesis for the Synthesis of Unsaturated Nitrogen Heterocycles

Emilia J. Groso

,

Corinna S. Schindler *

Department of Chemistry, Willard Henry Dow Laboratory, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA Email: corinnas@umich.edu

› Author Affiliations

Abstract

All articles of this category

Published as part of the 50 Years SYNTHESIS – Golden Anniversary Issue

Abstract

This short review summarizes recent advances relating to the application of ring-closing olefin-olefin and carbonyl-olefin metathesis reactions towards the synthesis of unsaturated five- and six-membered nitrogen heterocycles. These developments include catalyst modifications and reaction designs that will enable access to more complex nitrogen heterocycles.

1 Introduction

2 Expansion of Ring-Closing Metathesis Methods

3 Evaluation of Catalyst Design

4 Indenylidene Catalysts

5 Unsymmetrical N-Heterocyclic Carbene Ligands

6 Carbonyl-Olefin Metathesis

7 Conclusions

Key words

RCM - carbonyl-olefin metathesis - nitrogen heterocycles - catalyst design - ruthenium - Lewis acid catalysis

Full Text

References

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