CC BY-ND-NC 4.0 · Synthesis 2019; 51(05): 1100-1114
DOI: 10.1055/s-0037-1611651
short review
Copyright with the author

Recent Advances in the Application of Ring-Closing Metathesis for the Synthesis of Unsaturated Nitrogen Heterocycles

Emilia J. Groso
,
Department of Chemistry, Willard Henry Dow Laboratory, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA   Email: corinnas@umich.edu
› Author Affiliations
We thank the University of Michigan Office of Research and the NIH/National Institute of General Medical Sciences (R01-GM118644) for financial support. E.J.G. thanks the National Science Foundation for a predoctoral fellowship. C.S.S. thanks the David and Lucile Packard Foundation, the Alfred P. Sloan Foundation, and the Camille and Henry Dreyfus Foundation.
Further Information

Publication History

Received: 09 December 2018

Accepted: 14 December 2018

Publication Date:
08 February 2019 (online)

Published as part of the 50 Years SYNTHESIS – Golden Anniversary Issue

Abstract

This short review summarizes recent advances relating to the application of ring-closing olefin-olefin and carbonyl-olefin metathesis reactions towards the synthesis of unsaturated five- and six-membered nitrogen heterocycles. These developments include catalyst modifications and reaction designs that will enable access to more complex nitrogen heterocycles.

1 Introduction

2 Expansion of Ring-Closing Metathesis Methods

3 Evaluation of Catalyst Design

4 Indenylidene Catalysts

5 Unsymmetrical N-Heterocyclic Carbene Ligands

6 Carbonyl-Olefin Metathesis

7 Conclusions

 
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