α-Arylation of Amides from α-Halo Amides Using Metal-Catalyzed Cross-Coupling Reactions

Published as part of the 50 Years SYNTHESIS – Golden Anniversary Issue

Abstract

Metal-catalyzed α-arylation of amides from α-halo amides with organometallic reagents is reviewed. The article includes Suzuki–Miyaura, Kumada–Corriu, Negishi, and Hiyama cross-coupling reactions.

1 Introduction

2 Suzuki–Miyaura Cross-Coupling

2.1 Palladium Catalysis

2.2 Nickel Catalysis

3 Kumada–Corriu Cross-Coupling

3.1 Nickel Catalysis

3.2 Iron Catalysis

3.3 Cobalt Catalysis

4 Negishi Cross-Coupling

5 Hiyama Cross-Coupling

6 Conclusion

Key words

amide - arylation - cross-coupling - metal catalysis

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