Synthesis 2019; 51(04): 842-847
DOI: 10.1055/s-0037-1611018
psp
© Georg Thieme Verlag Stuttgart · New York

A Facile Synthesis of N-Boc-azocan-5-one

Maricela Morales-Chamorro
,
Alfredo Vázquez*
Facultad de Química, Universidad Nacional Autónoma de México, Circuito Interior S/N, Ciudad Universitaria 04510, CDMX, México   Email: joseavm@unam.mx
› Author Affiliations
Facultad de Química, UNAM. Grant PAIP 5000-9062.
Further Information

Publication History

Received: 15 August 2018

Accepted after revision: 16 September 2018

Publication Date:
10 October 2018 (eFirst)

Abstract

The azacycloalkane 1-azocan-5-one is embedded in the structure of several products of natural origin displaying a variety of bioactivities. Two convenient and straightforward routes were developed to synthesize N-Boc-azocan-5-one from readily available raw materials featuring a ring-closing metathesis (RCM) reaction as the key step.

Supporting Information

 
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