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DOI: 10.1055/s-0036-1590814
Recent Advances in the Carbon–Carbon Bond-Forming Reactions of N-Acylketimines
Publication History
Received: 30 April 2017
Accepted after revision: 02 June 2017
Publication Date:
26 June 2017 (online)


Dedicated to Professor Herbert Mayr on the occasion of his 70th birthday
Abstract
N-Acylketimines are important synthetic building blocks used in the synthesis of a wide variety of functional amino compounds including cyclic and acyclic products. This review focuses on carbon–carbon bond-forming reactions of N-acylketimines to construct amino compounds having tetrasubstituted carbon centers.
1 Introduction
2 Preparation of N-Acylketimines
2.1 Nucleophilic Addition of Amide Derivatives
2.2 Acylation of Imine Derivatives
2.3 An Aza-Wittig-Type Reaction
2.4 Oxidation of Amine Precursors
3 Reactions of N-Acylketimines
3.1 Cyclic Ketimines
3.2 Acyclic Ketimines
4 Conclusions