CC BY 4.0 · Synthesis 2017; 49(15): 3323-3336
DOI: 10.1055/s-0036-1589046
short review
Copyright with the author

50 Years of Zweifel Olefination: A Transition-Metal-Free Coupling

School of Chemistry, University of Bristol, Cantock’s Close, Bristol, BS8 1TS, UK   Email: v.aggarwal@bristol.ac.uk
,
School of Chemistry, University of Bristol, Cantock’s Close, Bristol, BS8 1TS, UK   Email: v.aggarwal@bristol.ac.uk
› Author Affiliations
We thank EPSRC (EP/I038071/1) and the European Research Council (advanced grant 670668) for financial support.
Further Information

Publication History

Received: 15 May 2017

Accepted after revision: 16 May 2017

Publication Date:
11 July 2017 (online)


Dedicated to Professor Herbert Mayr on the occasion of his 70th birthday

Abstract

The Zweifel olefination is a powerful method for the stereoselective synthesis of alkenes. The reaction proceeds in the absence of a transition-metal catalyst, instead taking place by iodination of vinyl boronate complexes. Pioneering studies into this reaction were reported in 1967 and this short review summarizes developments in the field over the past 50 years. An account of how the Zweifel olefination was modified to enable the coupling of robust and air-stable boronic esters is presented followed by a summary of current state of the art developments in the field, including stereodivergent olefination and alkynylation. Finally, selected applications of the Zweifel olefination in target-oriented synthesis are reviewed.

1 Introduction

2.1 Zweifel Olefination of Vinyl Boranes

2.2 Zweifel Olefination of Vinyl Borinic Esters

2.3 Extension to Boronic Esters

3.1 Introduction of an Unsubstituted Vinyl Group

3.2 Coupling of α-Substituted Vinyl Partners

3.3 Syn Elimination

4 Zweifel Olefination in Natural Product Synthesis

5 Conclusions and Outlook

 
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