Intramolecular Hydroalkoxylation/Reduction and Hydroamination/Reduction of Unactivated Alkynes Using a Silane–Iodine Catalytic SystemJapan Society for the Promotion of Science�, Grant Number: 'JP16K08162'�, Japan Agency for Medical Research and Development��.
Received: 31 March 2017
Accepted after revision: 02 May 2017
24 May 2017 (eFirst)
Published as part of the Special Topic Modern Cyclization Strategies in Synthesis
A transition-metal-free silane–iodine catalytic system comprising I2 and Et3SiH promotes intramolecular hydroalkoxylation/reduction and hydroamination/reduction of unactivated alkynes. This system allows the reaction to proceed at room temperature affording 2,4- and 2,5-disubstituted pyrrolidines as well as a 2,3-disubstituted tetrahydrofuran with high diastereoselectivity.