Copper-Catalyzed Decarboxylative Trifluoromethylation of Propargyl Bromodifluoroacetates
Received: 28 February 2014
Accepted after revision: 05 May 2014
12 June 2014 (eFirst)
The development of efficient methods for accessing fluorinated functional groups is desirable. Herein, we report a two-step method that utilizes catalytic copper for the decarboxylative trifluoromethylation of propargyl bromodifluoroacetates is described. This protocol affords a mixture of propargyl trifluoromethanes and trifluoromethyl allenes.