Copper-Catalyzed Decarboxylative Trifluoromethylation of Propargyl Bromodifluoroacetates

Brett R. Ambler; Santosh Peddi; Ryan A. Altman

doi:10.1055/s-0033-1339128

Synthesis, Inhaltsverzeichnis

Synthesis 2014; 46(14): 1938-1946
DOI: 10.1055/s-0033-1339128

special topic

Copper-Catalyzed Decarboxylative Trifluoromethylation of Propargyl Bromodifluoroacetates

Brett R. Ambler

^aDepartment of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045, USA

,

Santosh Peddi

^bDepartment of Pharmacy, Birla Institute of Technology & Science, Pilani–Hyderabad Campus, Jawahar Nagar, Shameerpet Mandal, Hyderabad, 500078 Andhra Pradesh, India Fax: +1(785)8645326 eMail: raaltman@ku.edu

,

Ryan A. Altman*

^aDepartment of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045, USA

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Abstract

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Abstract

The development of efficient methods for accessing fluorinated functional groups is desirable. Herein, we report a two-step method that utilizes catalytic copper for the decarboxylative trifluoromethylation of propargyl bromodifluoroacetates is described. This protocol affords a mixture of propargyl trifluoromethanes and trifluoromethyl allenes.

Key words

copper - catalysis - trifluoromethylation - decarboxylation - alkynes

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Referenzen

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