Synlett 2013; 24(8): 903-919
DOI: 10.1055/s-0032-1318497
account
© Georg Thieme Verlag Stuttgart · New York

A New Tool in the Toolbox: Electron-Withdrawing Group Activated ­Ruthenium Catalysts for Olefin Metathesis

Tomasz K. Olszewski
a  Apeiron Catalysts, Dunska 9, 54-427 Wroclaw, Poland
,
Michal Bieniek
a  Apeiron Catalysts, Dunska 9, 54-427 Wroclaw, Poland
,
Krzysztof Skowerski
a  Apeiron Catalysts, Dunska 9, 54-427 Wroclaw, Poland
,
Karol Grela*
b  Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland
c  University of Warsaw, Faculty of Chemistry, Pasteura 1, 02-093 Warsaw, Poland   Fax: +48(22)3432109   Email: klgrela@gmail.com
› Author Affiliations
Further Information

Publication History

Received: 22 January 2013

Accepted after revision: 04 March 2013

Publication Date:
05 April 2013 (eFirst)

Abstract

This account describes the discovery and development of efficient electron-withdrawing group activated Hoveyda–Grubbs catalysts, including a nitro-substituted catalyst and their applications in the syntheses of complex molecules.

1 Introduction

2 EWG-Activated Hoveyda–Grubbs Complexes

2.1 The Discovery and the Story Behind It

2.2 The Nitro-Substituted Hoveyda–Grubbs Catalyst

2.3 pH-Responsive Catalysts

2.4 Fine-Tuning of the EWG Fragment

3 Applications of the Nitro-Substituted Hoveyda–Grubbs Catalyst in the Preparation of Compounds of Biological Relevance

3.1 Synthesis of BILN 2061

4 Concluding Remarks

 
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