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Synthesis 2011(2): 243-250  
DOI: 10.1055/s-0030-1258349
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Simple, Efficient, and Recyclable Phosphine-Free Catalytic System for Carbonylative Suzuki Coupling Reaction of Aryl and Heteroaryl Iodides

Ziyauddin S. Qureshi, Krishna M. Deshmukh, Pawan J. Tambade, Bhalchandra M. Bhanage*
Department of Chemistry, Institute of Chemical Technology (Autonomous), N. Parekh Marg, Matunga, Mumbai 400 019, India
Fax: +91(22)24145614; e-Mail: bhalchandra_bhanage@yahoo.com; e-Mail: bm.bhanage@ictmumbai.edu.in;
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Publikationsverlauf

Received 11 October 2010
Publikationsdatum:
03. Dezember 2010 (online)

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Abstract

The carbonylative Suzuki cross-coupling reaction of arylboronic acid with aryl and heteroaryl iodides using polymer supported palladium-N-heterocyclic carbene complex (PS-Pd-NHC) as an efficient heterogeneous, recyclable catalyst is described. The developed catalytic system is found to be effective for the carbonylative coupling reaction of aryl, heteroaryl, and bicyclic heteroaryl iodides (5-iodoindole and 3-iodoquinoline) with various arylboronic acid derivatives providing good to excellent yields of the desired products. The protocol is advantageous due to the ease in handling of the catalyst and simple workup procedure, and environmentally benign with effective catalyst recyclability.

Key words

biaryl ketones - boron - heterogeneous catalysis - palladium - Suzuki carbonylation

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