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DOI: 10.1055/s-2003-41472
Direct Synthesis of Benzoylpyridines from Chloropyridines via a Palladium-Carbene Catalyzed Carbonylative Suzuki Cross-Coupling Reaction
Publication History
Publication Date:
19 September 2003 (online)
Abstract
The use of N-heterocyclic carbene-type ligands with palladium catalysts allows the activation of chloropyridines and chloroquinoline towards carbonylative cross-coupling with phenylboronic acid for the synthesis of unsymmetrical biaryl ketones.
Key words
palladium - N-heterocyclic carbene ligand - pyridyl chloride
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References
In a number of coupling reactions of aryl chlorides, it was found that a 1:1 Pd-ligand ratio (ligand = N-heterocyclic carbene, phosphine, …) led to optimum reaction rates (see ref. 2 and ref. 5b for N-heterocyclic carbene ligands).
10TOF: turnover frequencies defined as the number of moles of substrate transformed per mole of catalyst and per hour calculated after one hour of reaction.